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Self-cleaning and surface chemical reactions during hafnium dioxide atomic layer deposition on indium arsenide

Atomic layer deposition (ALD) enables the ultrathin high-quality oxide layers that are central to all modern metal-oxide-semiconductor circuits. Crucial to achieving superior device performance are the chemical reactions during the first deposition cycle, which could ultimately result in atomic-scale perfection of the semiconductor-oxide interface. Here, we directly observe the chemical reactions

Controlled Oxidation and Self-Passivation of Bimetallic Magnetic FeCr and FeMn Aerosol Nanoparticles

Nanoparticle generation by aerosol methods, particularly spark ablation, has high potential for creating new material combinations with tailored magnetic properties. By combining elements into complex alloyed nanoparticles and controlling their size and structure, different magnetic properties can be obtained. In combination with controlled deposition, to ensure nanoparticle separation, it is poss

Increased levels of anti-dsDNA antibodies in immune complexes before treatment with belimumab associate with clinical response in patients with systemic lupus erythematosus

Introduction: Immune complexes are of importance in systemic lupus erythematosus pathogenesis, and autoantibodies are believed to participate in immune complex formation. Quantification of autoantibody levels in circulating IC might be of prognostic value. Methods: A C1q-binding-eluting technique was applied to purify immune complexes from 55 belimumab-treated systemic lupus erythematosus patients

Observing growth under confinement : Sn nanopillars in porous alumina templates

Using a micro-focused high-energy X-ray beam, we have performed in situ time-resolved depth profiling during the electrochemical deposition of Sn into an ordered porous anodic alumina template. Combined with micro-diffraction we are able to follow the variation of the structure at the atomic scale as a function of depth and time. We show that Sn initially deposits at the bottom of the pores, and f

High Prevalence and Disease Correlation of Autoantibodies Against p40 Encoded by Long Interspersed Nuclear Elements in Systemic Lupus Erythematosus

Objective: Long interspersed nuclear element 1 (LINE-1) encodes 2 proteins, the RNA binding protein p40 and endonuclease and reverse transcriptase (open-reading frame 2p [ORF2p]), which are both required for LINE-1 to retrotranspose. In cells expressing LINE-1, these proteins assemble with LINE-1 RNA and additional RNA binding proteins, some of which are well-known autoantigens in patients with sy

Residual Stroke Risk Among Patients With Atrial Fibrillation Prescribed Oral Anticoagulants : A Patient-Level Meta-Analysis From COMBINE AF

BACKGROUND: Despite oral anticoagulation, patients with atrial fibrillation (AF) remain at risk of ischemic stroke and systemic embolism (SE) events. For patients whose residual risk is sufficiently high, additional therapies might be useful to mitigate stroke risk. METHODS AND RESULTS: Individual patient data from 5 landmark trials testing oral anticoagulation in AF were pooled in A Collaboration

The association between novel urinary kidney damage biomarkers and coronary atherosclerosis in an apparently healthy population

Several novel urinary kidney damage biomarkers predict the progression of kidney disease. However, the relations of these biomarkers to atherosclerosis, a major consequence of kidney disease, are less studied. Urinary levels of several biomarkers, including kidney injury molecule-1 (KIM-1), osteopontin, epidermal growth factor, and Dickkopf-3, were assessed in participants enrolled in the Swedish

Clinical significance of a new diagnosis of atrial fibrillation in patients with vascular disease

Background: The Cardiovascular Outcomes for People Using Anticoagulation Strategies (COMPASS) trial enrolled patients with vascular disease but excluded patients requiring oral anticoagulation. Objective: We aimed to explore the clinical significance of a new diagnosis of atrial fibrillation (AF) during follow-up. Methods: New AF was identified from hospitalization, study drug discontinuation, and

Successful prevention of organic solvent induced disorders : history and lessons

In this discussion paper, we describe the history of the science and societal action resulting in the mitigation of neurotoxic disorders from exposure to organic solvents at the workplaces in Sweden. When alkyd paints were introduced in large scale in construction painting in the 1960s and 1970s, Scandinavian unions voiced increasing concern as members reported symptoms like headache and vertigo,

Exposure to high levels of perfluoroalkyl substances through drinking water and risk of cardiovascular morbidity and mortality in a Swedish register-based study

INTRODUCTION: Epidemiological studies focusing on the association of exposure to perfluoroalkyl substances (PFAS) with cardiovascular disease (CVD) morbidity and mortality are limited, with inconsistent findings.OBJECTIVES: This register-based study aimed to investigate the associations between exposure to PFAS and the risk of CVD morbidity and mortality in a Swedish population exposed to PFAS, do

The Hope and the Hype of Artificial Intelligence for Syncope Management

ImportanceSyncope remains a diagnostic challenge despite advancements in testing and treatment. Cardiac syncope is an independent predictor of mortality and can be difficult to distinguish from other causes of transient loss of consciousness (TLOC).ObservationsThe cause of TLOC is often unclear, hospitalization criteria are ambiguous, diagnostic tests are frequently non-informative, and assessment

Digital platforms for circular shopping: slowing down and speeding up second-hand clothing consumption

This paper aims to empirically explore and conceptualise how circular fashion platforms enable and shape the practice of secondhand clothes shopping. Taking a shopping-as-practice approach and drawing on an ethnographically inspired study, this paper explores how a Swedish digital second-hand commerce platform enables different modes of shopping. The analysis shows that this platform and its socio

A systematic literature review of time-use effects from increased ICT adoption and its consequences for lifestyle climate implications

This systematic literature review assesses the current state of knowledge on how increased ICT use affects individual time-use patterns and the associated implications for lifestyle climate implications. While the environmental impacts of ICT have been widely debated in terms of direct energy consumption, there has been limited focus on the indirect time-use effects. The review draws on 101 articl

Prevalence and Determinants of the Composite Index of Anthropometric Failure in Children Under Five Years in Bangladesh: Insights From a National Survey

ABSTRACT Child undernutrition remains a significant public health issue in Bangladesh, with high rates of stunting, wasting, and underweight. The Composite Index of Anthropometric Failure (CIAF) offers a comprehensive tool for assessing overall undernutrition. Although previous studies in Bangladesh have utilized CIAF, they have relied on older datasets. Estimating the current status is essential

Aortic valve calcification across stages of dysglycemia in middle-aged individuals from the general population

Background: Aortic valve calcification (AVC) is an underlying pathophysiological mechanism in aortic stenosis, which shares many risk factors with diabetes. However, the association between dysglycemia and early stages of AVC remains unclear. The aim was to examine the associations between stages of dysglycemia and signs of AVC among middle-aged individuals from the general population. Methods: Th

Diagnostic pathways for earlier diagnosis and treatment towards better outcomes for adults living with chronic breathlessness

Chronic breathlessness is a common and distressing symptom, negatively impacting physical function and quality of life. Many individuals presenting with chronic breathlessness wait years for an explanatory diagnosis, leading to delays in accessing effective treatments and worse individual outcomes including premature mortality. In addition, delays to diagnosis are associated with increased healthc