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We aim to obtain a fast overview of the HTA question and to refine-specify the PICO for information retrieval, using bibliometrics, text mining, and vizualization tools. The PICO question is a well-established format within the HTA process. Depending on the HTA question the PICO can be difficult to verify and limit. To support the HTA-project groups and the informaton specialistst to establish the

The thyrocytes are exposed to high levels of oxidative stress which could induce DNA damages. Base excision repair (BER) is one of the principal mechanisms of defense against oxidative DNA damage, however recent evidences suggest that also nucleotide excision repair (NER) could be involved. The aim of present work was to identify novel differentiated thyroid cancer (DTC) risk variants in BER and N

We report on a simple but powerful approach to grow high material quality InSb and GaSb nanowires in a commonly used tube furnace setup. The approach employs a process of stable heating at a high temperature and then cooling down naturally to room temperature with the nanowire growth occurred effectively during the naturally cooling step. As-grown nanowires are analyzed using a scanning electron m

The development of oncolytic viruses has recently made great progress towards being available to cancer patients. With the breakthrough into clinics, it is crucial to analyze the existing clinical experience and use it as a basis for treatment improvements. Here we report clinical data from 290 patients treated with oncolytic adenovirus. Using clinical variables and treatment characteristics, we c

With their nanometer size cross-section and high aspect ratio, semiconducting nanowires have properties that make them promising as building blocks in future electronic and optoelectronic devices. Because of their small size, their optical and electrical properties can differ from their bulk counterparts, and their geometry allows for material combinations not accessible in thin films. Moreover, n

Experiments where gasoline exhaust was exposed to UV-radiation to examine Secondary Organic Aerosol (SOA) formation were performed in a smog chamber. The Aerosol Mass Yield (formed SOA/reacted precursor mass) was determined and compared with the yield from a pure precursor experiment in the chamber and from results reported in literature. Preliminary results show that the majority of the organic a

Nanowires have the ability to absorb light much more efficient than conventional thin film layers. This makes them candidates for the development of new types of solar cells that have higher efficiency and lower material usage than current technologies. In this thesis fabrication of nanowires with techniques suitable for large area applications are investigated. The nanowires are grown by either M

This thesis focuses on charge transport in semiconductor InSb nanowire quantum devices, including the electron transport, the hole transport, and the Cooper pair transport. Devices in which InSb semiconductor nanowire quantum dots are coupled with normal metals, superconductors or the proximity effect induced topological superconductors are fabricated and measured. Firstly, we have fabricated and

We present a synchrotron-based XPS investigation on the interface between InAs and Al2O3 or HfO2 layers, deposited by ALD at different temperatures, for InAs substrates with different surface orientations as well as for InAs nanowires. We reveal the composition of the native Oxide and how the high-k layer deposition reduces Oxide components. We demonstrate some of the advantages in using synchrotr

In this work, we present a stroboscopic detection technique for the study of oscillating nanoscale objects. This optical read-out gives a position accuracy better than 1 nm which is a fraction of both the diffraction limit and the pixel size. The advantage of this stroboscopic method compared to conventional time-averaging techniques, is the time-resolution it provides as well as being non-invasiv

This thesis investigates electronic transport in several types of novel heterostructure nanowires. The first part of the thesis focuses on band-to-band mechanisms in heterostructure nanowires for low-power electronics. First, tunnel field-effect transistors (TFETs) based on InP/GaAs heterostructure nanowires with n-i-p doping profile are explored. To further enhance the interband tunneling current