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Objectives To describe the prevalence and longitudinal course of radiographic, erosive and symptomatic hand osteoarthritis (HOA) in the general population. Methods Framingham osteoarthritis (OA) study participants obtained bilateral hand radiographs at baseline and 9-year follow-up. The authors defined radiographic HOA at joint level as Kellgren-Lawrence grade (KLG)>= 2, erosive HOA as KLG >= 2 pl

We show that the free-carrier absorption in quantum cascade lasers (QCLs) is very small and radically different from the classical Drude result due to the orthogonality between the direction of the carrier free motion and the electric field of the laser emission. A quantum mechanical calculation of the free-carrier absorption and intersubband oblique absorption induced by interface defects, Coulom

Comparative data on sick leave within musculoskeletal disorders (MSDs) is limited. Our objective was to give a descriptive overview of sick leave patterns in different MSDs.

Current theoretical attempts to understand the reversible formation of stable microtubules and virus shells are generally based on shape-specific building blocks or monomers, where the local curvature of the resulting structure is explicitly built-in via the monomer geometry. Here we demonstrate that even simple ellipsoidal colloids can reversibly self-assemble into regular tubular structures when

Since Durkheim’s seminal work over a century ago, research has repeatedly shown that individuals with higher levels of social integration, social networks and social support have better health status. However, the recent introduction of a contextual phenomenon known as social capital to the field of public health has sparked lively debate as to how it may also influence the health of individuals,

Purpose Hip dislocation after arthroplasty for femoral neck fractures (FNF) remains a serious complication. The aim of our study was to investigate FNF patients treated with THA, with a special focus of comparing the effect of surgical approach and femoral head size on the risk of revision for dislocation. Methods Data were derived from the Lithuanian Arthroplasty Register, and we calculated the c

In this paper a new third-generation amperometric biosensor for lactose determination is described. The biosensor is based on the highly efficient direct electron transfer (DET) between cellobiose dehydrogenase (CDH) from Phanerochaete sordida (PsCDH) and single walled carbon nanotubes (SWCNT). The SWNCTs were surface modified with aryl diazonium salts of p-phenylenediamine (NH2-PD) and deposited

Background: There is an association between a greater adherence to a Mediterranean diet and a reduced risk of developing chronic diseases. However, it is not clear whether this dietary pattern may be protective also against the development of obesity. Objective: We assessed the association between the adherence to the Mediterranean dietary pattern (MDP), prospective weight change, and the incidenc

We present an approach for electrode modification by using the oxidoreductase cellobiose dehydrogenase from the ascomycete Corynascus thermophilus (CtCDH). CtCDH is a two-domain enzyme, in which the catalytic dehydrogenase domain (DHCDH) hosts flavin adenine dinucleotide (FAD) as cofactor and is connected through a flexible linker to a small cytochrome domain with a heme b cofactor (CYTCDH). This

We study, using fluorescent confocal laser scanning microscopy, the directed self-assembly of cross-linked ionic microgels under the influence of an applied alternating electric field at different effective packing fractions phi(eff) in real space. We present a detailed description of the contribution of the electric field to the soft interparticle potential, and its influence on the phase diagram

There are abundant examples of nanoclusters and inorganic microcrystals in biology. Their study under physiologically relevant conditions remains challenging due to their heterogeneity, instability, and the requirements of sample preparation. Advantages of using neutron diffraction and contrast matching to characterize biomaterials are highlighted in this article. We have applied these and complem

Background and purpose - The incidence of knee osteoarthritis will most likely increase. We analyzed historical trends in the incidence of knee arthroplasty in Sweden between 1975 and 2013, in order to be able to provide projections of future demand. Patients and methods - We obtained information on all knee arthroplasties in Sweden in the period 1975-2013 from the Swedish Knee Arthroplasty Regist

Recent advances in coherent multidimensional spectroscopy have boosted interest in exciton coherences in light harvesting complexes. We present nonperturbative calculations of two-dimensional (2D) electronic spectroscopy from a fifth-order phase-matching direction. The calculations show clear patterns that correspond to the electronic structure of one- and two-exciton manifolds of a Fenna-Matthews

Photosynthesis is the process by which energy of light is converted into chemical energy by plants, algae and photosynthetic bacteria. For this, highly specialized pigment-proteins have evolved that capture the light and transform the short-lived excited states of pigment molecules into a stable transmembrane potential. By close scrutiny of organization and processes of the photosynthetic pigment

Stroke genetics includes several topics of clinical interest, including (1) molecular genetic variations affecting risk of monogenic stroke syndromes; (2) molecular genetic variations affecting risk of common stroke syndromes, sometimes with specific effects on risk of specific main types of stroke or subtypes of ischemic and hemorrhagic stroke; (3) genetics of conditions associated with stroke ri

Smoking, diabetes, male sex, hypercholesterolaemia and hypertension are well-established risk factors for the development of coronary artery disease (CAD). However, less is known about their role in influencing the outcome in the event of an acute coronary syndrome (ACS). The aim of this study was to determine if these risk factors are associated specifically with acute myocardial infarction (MI)

PURPOSE: To analyze reduction of intraocular pressure (IOP) by argon laser trabeculoplasty (ALT) in the Early Manifest Glaucoma Trial and factors influencing the effect of such treatment. DESIGN: Cohort study based on 127 patients from the treatment group of the Early Manifest Glaucoma Trial, a randomized clinical trial. METHODS: Patients randomized to the treatment arm of the Early Manifest Gla

We report the synthesis of thermosensitive raspberry-like hybrid microgels. They consist of a poly(N-isopropylacrylamide) core decorated with in situ formed silica particles. A linking silane agent was copolymerized to help the anchoring of silica particles formed by a controlled silica precursor addition onto the outer shell. The thermosensitive behaviour is tuneable by adjusting the size of the