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Insufficient oxygen and nutrient supply often restrain solid tumor growth, and the hypoxia-inducible factors (HIF) 1 alpha and HIF-2 alpha are key transcription regulators of phenotypic adaptation to low oxygen levels. Moreover, mouse gene disruption studies have implicated HIF-2 alpha in embryonic regulation of tyrosine hydroxylase, a hallmark gene of the sympathetic nervous system. Neuroblastoma

Background Oral contraceptives were introduced almost 50 years ago, and over 100 million women currently use them. Oral contraceptives can reduce the risk of ovarian cancer, but the eventual public-health effects of this reduction will depend on how long the protection lasts after use ceases. We aimed to assess these effects. Methods Individual data for 23 257 women with ovarian cancer (cases) a

Background: To date, no attempt has been made to systematically determine the apportionment of the hepatocellular carcinoma burden in Europe or North America among established risk factors.MethodsUsing data collected from 1992 to 2006, which included 4 409 809 person-years in the European Prospective Investigation into Cancer and nutrition (EPIC), we identified 125 case patients with hepatocellula

New synthetic hybrid materials and their increasing complexity have placed growing demands on crystal growth for single-crystal X-ray diffraction analysis. Unfortunately, not all chemical systems are conducive to the isolation of single crystals for traditional characterization. Here, small-molecule serial femtosecond crystallography (smSFX) at atomic resolution (0.833 Å) is employed to characteri

In pancreatic ductal adenocarcinoma (PDAC), the dense desmoplastic stroma and insufficient infiltrating T cells represent a significant barrier to effective immunotherapy. In this phase I, dose-escalation study, previously registered at the Dutch Trial Register and later on at ClinicalTrial (NCT05650918), we administer an autologous dendritic cell (DC) vaccine (MesoPher) with an agonistic CD40-spe

Infectious diseases are an existential health threat, potentiated by emerging and re-emerging viruses and increasing bacterial antibiotic resistance. Targeted treatment of infectious diseases re-quires precision diagnostics, especially in cases where broad-range therapeutics such as antibiotics fail. There is thus an increasing need for new approaches to develop sensitive and specific in vitro dia

Rhesus macaques (RMs) are a vital model for studying human disease and are invaluable to preclinical vaccine research, particularly for the study of broadly neutralizing antibody responses. Such studies require robust genetic resources for antibody-encoding genes within the immunoglobulin (IG) loci. The complexity of the IG loci has historically made them challenging to characterize accurately. To

Despite its continued observational successes, there is a persistent (and growing) interest in extending cosmology beyond the standard model, ΛCDM. This is motivated by a range of apparently serious theoretical issues, involving such questions as the cosmological constant problem, the particle nature of dark matter, the validity of general relativity on large scales, the existence of anomalies in

There is limited evidence on the association between dietary folate intake and the risk of breast cancer (BC) by hormone receptor expression in the tumors. We investigated the relationship between dietary folate and BC risk using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). A total of 367993 women age 35 to 70 years were recruited in 10 European countries. Dur

We present the first results of K2-OjOS, a collaborative project between professional and amateur astronomers primarily aimed to detect, characterize, and validate new extrasolar planets. For this work, 10 amateur astronomers looked for planetary signals by visually inspecting the 20 427 light curves of K2 campaign 18 (C18). They found 42 planet candidates, of which 18 are new detections and 24 ha

Investigating the chemical homogeneity of stars born from the same molecular cloud at virtually the same time is very important for our understanding of the chemical enrichment of the interstellar medium and with it the chemical evolution of the Galaxy. One major cause of inhomogeneities in the abundances of open clusters is stellar evolution of the cluster members. In this work, we investigate va

Phil 760 Printed from: Homage à Wlodek. Philosophical Papers Dedicated to Wlodek Rabinowicz. Eds. T. Rønnow-Rasmussen, B. Petersson, J. Josefsson & D. Egonssson, 2007. www.fil.lu.se/HomageaWlodek Happiness and Subjective Desire Satisfaction: Wayne Davis’s Theory of Happiness* Fred Feldman University of Massachusetts at Amherst ffeldman@philos.umass.edu ABSTRACT: There is a lively debate about the

https://www.fil.lu.se/hommageawlodek/site/papper/FeldmanFred.pdf - 2026-05-10

This project explores the design of a modular, wall-mounted shelving system that merges the practicality of hardware storage with the refined aesthetic of contemporary furniture. Driven by an interest in modularity and metal as a design material, the project investigates how adaptability, sustainability and visual clarity can coexist in a single solution. The result is a system constructed in recy

Microsoft Word - Prosthesis_attachment_device_for_individuals_with_trans-radial_amputations_PRINT.docx Division  of  Solid  Mechanics     ISRN LUTFD2/TFHF--12/5166--SE (1-103)             PROSTHESIS  ATTACHMENT  DEVICE  FOR   INDIVIDUALS  WITH  TRANS-­‐RADIAL     AMPUTATIONS           Master’s  Dissertation  by   Lukasz  Szychlinski       Supervisors   Ingrid  Svensson,  Div.  of  Solid  Mechanics

https://www.solid.lth.se/fileadmin/hallfasthetslara/utbildning/examensarbete/TFHF5166.pdf - 2026-05-09

swp0000.dvi Egalitarianism, option luck and insurance markets Marc Fleurbaey∗ August 31, 2006 Abstract It is argued here that individuals should never be held responsi- ble for being lucky or unlucky, so that the notion of option luck is prima facie unacceptable. But applying the Conditional Equality and Egalitarian Equivalence criteria to problems of allocation under risk provides a rationale for

https://www.fil.lu.se/hommageawlodek/site/papper/FleurbaeyMarc.pdf - 2026-05-10

We report the discovery of TOI-2285b, a sub-Neptune-sized planet transiting a nearby (42 pc) M dwarf with a period of 27.3 d. We identified the transit signal from the Transiting Exoplanet Survey Satellite photometric data, which we confirmed with ground-based photometric observations using the multiband imagers MuSCAT2 and MuSCAT3. Combining these data with other follow-up observations including

BACKGROUND: High carbohydrate intake raises blood triglycerides, glucose, and insulin; reduces HDLs; and may increase risk of coronary heart disease (CHD). Epidemiological studies indicate that high dietary glycemic index (GI) and glycemic load (GL) are associated with increased CHD risk. OBJECTIVES: The aim of this study was to determine whether dietary GI, GL, and available carbohydrates are ass

Conflicting evidence exists regarding the association between saturated fatty acids (SFAs) and type 2 diabetes. In this longitudinal case-cohort study, we aimed to investigate the prospective associations between objectively measured individual plasma phospholipid SFAs and incident type 2 diabetes in EPIC-InterAct participants.

The comparative performance of existing models for prediction of type 2 diabetes across populations has not been investigated. We validated existing non-laboratory-based models and assessed variability in predictive performance in European populations.

Background: Understanding the health consequences associated with exposure to risk factors is necessary to inform public health policy and practice. To systematically quantify the contributions of risk factor exposures to specific health outcomes, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 aims to provide comprehensive estimates of exposure levels, relative health r