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Soft tissue angiofibroma is rare and has characteristic histomorphological and genetic features. For diagnostic purposes, there are no specific antibodies available. Fourteen lesions (6 females, 8 males; age range 7-67 years) of the lower extremities (12) and trunk (2) were investigated by immunohistochemistry, including for the first time NCOA2. NCOA2 was also tested in a control group of other s

Naturally occurring extracellular vesicles (EVs) play essential roles in intracellular communication and delivery of bioactive molecules. Therefore it has been suggested that EVs could be used for delivery of therapeutics. However, to date the therapeutic application of EVs has been limited by number of factors, including limited yield and full understanding of their biological activities. To addr

In rubber materials, both natural rubber and synthetic rubber, several different contact allergenic chemicals are added to the batch before vulcanization. These compounds are relevant for investigation of rubber allergy of workers in rubber factories. The number of workers in the rubber industry has declined, owing to increased automation of the process; however, the number of users of rubber prod

Background: Use of disposable protective gloves in health care is necessary both to protect patients and personnel. However, the use might also be responsible for skin disease among persons wearing the gloves. Dermatitis may be caused by additives in the gloves, either from manufacturing of the glove material or components in coatings applied after vulcanization. Objectives: We wanted to analyse t

BACKGROUND: Permanent pacemaker implantation (PPM) early after cardiac transplantation has been shown not to predict a worse outcome. However, the requirement for pacing late after transplantation and its prognostic implications are not fully known. We describe the clinical indications, risk factors and long-term outcome in patients who required pacing early and late after transplantation.METHODS:

Protein G is a streptococcal cell wall protein with separate binding sites for IgG and human serum albumin (HSA). In the present work it was demonstrated that alpha 2-macroglobulin (alpha 2M) and kininogen, two proteinase inhibitors of human plasma, bound to protein G, whereas 23 other human proteins showed no affinity. alpha 2M was found to interact with the IgG-binding domains of protein G, and

Young children with visual impairments tend to engage less with their surroundings, limiting the benefits from activities at school. We investigated novel ways of using sound from a bracelet, such as speech or familiar noises, to tell children about nearby people, places and activities, to encourage them to engage more during play and help them move independently. We present a series of studies, t

We combine parallaxes from the first Gaia data release with the spectrophotometric distance estimation framework for stars in the fifth RAVE survey data release. The combined distance estimates aremore accurate than either determination in isolation - uncertainties are on average two times smaller than for RAVE-only distances (three times smaller for dwarfs), and 1.4 times smaller than TGAS parall

Eosinophils have emerged as multifaceted cells that contribute to tissue homeostasis. However, the impact of the microbiota on their frequency and function at mucosal sites remains unclear. Here, we investigated the role of the microbiota in the regulation of enteric eosinophils. We found that small intestinal (SI) eosinophilia was significantly greater in germ-free (GF) mice compared to specific

The ESA space astrometry mission Gaia will measure the positions, parallaxes and proper motions of the 1 billion brightest stars on the sky. Expected accuracies are in the 725 as range down to 15 mag and sub-mas accuracies at the faint limit (20 mag). The astrometric data are complemented by low-resolution spectrophotometric data in the 3301000 nm wavelength range and, for the brighter stars, radi

BACKGROUND: Carriers of germline mutations in the BRCA2 gene are known to be at high risk of breast and ovarian cancers, but the risks of other cancers in mutation carriers are uncertain. We investigated these risks in 173 breast-ovarian cancer families with BRCA2 mutations identified at 20 centers in Europe and North America.METHODS: Other cancer occurrence was determined in a final cohort of 372

Wegener's granulomatosis (WG) and microscopic polyangiitis (MPA) are both frequently associated with antineutrophil cytoplasmic autoantibodies (ANCA). Immunosuppressive treatment has dramatically improved outcome for these patients, but today we have to deal with the problems of relapses, cases refractory to treatment, and long-term side effects of therapy. This study comprises a consecutive serie

gamma-Trace, a small protein occurring in body fluids and in secretory and neuroendocrine cells, was demonstrated by immunohistochemical techniques in the cytoplasm of the tumor cells of 13 pituitary adenomas obtained at surgery and autopsy. Seven of the adenomas also contained LH immunoreactivity. FSH, TSH, and ACTH were each found in one gamma-trace-containing adenoma. gamma-Trace was also demon

SARS-CoV-2 has spread rapidly worldwide, causing the COVID-19 pandemic. Platelet activation and platelet-leukocyte complex formation are proposed to contribute to disease progression. Here, we report platelet and leukocyte activation during acute and convalescent COVID-19 in patients recruited between May-July 2020. Blood samples were analyzed by flow cytometry and ELISA using paired comparison be

Background: PAM50 breast cancer intrinsic subtyping adds prognostic information in early breast cancer; however, the role in metastatic disease is unclear. We aimed to identify PAM50 subtypes in primary tumors (PTs) and metastases to outline subtype changes and their prognostic role. Methods: RNA was isolated from PTs, lymph node metastases (LNMs), and distant metastases (DMs) in metastatic breast

Rice straw is regarded as one of the main cereal straws that are produced every year in substantial amounts. Typically, rice straw is burned by farmers as they could not find a more promising technique to dispose it. This burning produces particulates and carbon monoxide causing many adverse effects on the environment and the public health, and finding a way to efficiently utilise this biowaste re

Standardised data formats and data models are essential for data integration and interoperability, which in turn adds value to data by allowing its reuse in multiple contexts. For this reason, in recent years extensive efforts have been focused on standards development. When representing the built environment, 3D city models and Building Information Models are particularly relevant, and their inte

The Gaia-ESO Survey (GES) observed many open clusters as part of its programme to spectroscopically characterize the various Milky Way populations. GES spectroscopy and Gaia astrometry from its second data release are used here to assign membership probabilities to targets towards 32 open clusters with ages from 1 to 3800 Myr, based on maximum likelihood modelling of the 3D kinematics of the clust