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Obesity impairs the relaxant capacity of adipose tissue surrounding the vasculature (PVAT) and has been implicated in resultant obesity-related hypertension and impaired glucose intolerance. Resident immune cells are thought to regulate adipocyte activity. We investigated the role of eosinophils in mediating normal PVAT function. Healthy PVAT elicits an anti-contractile effect, which was lost in m

BACKGROUND: Non-fatal outcomes of disease and injury increasingly detract from the ability of the world's population to live in full health, a trend largely attributable to an epidemiological transition in many countries from causes affecting children, to non-communicable diseases (NCDs) more common in adults. For the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015), we

Initiation of adaptive immunity to particulate antigens in lymph nodes largely depends on their presentation by migratory dendritic cells (DCs). DC subsets differ in their capacity to induce specific types of immunity, allowing subset-specific DC-targeting to influence vaccination and therapy outcomes. Faithful drug design, however, requires exact understanding of subset-specific versus global act

Background Potassium disturbances per se increase the risk of ventricular fibrillation (VF). Whether potassium disturbances in the acute phase of ST-segment-elevation myocardial infarction (STEMI) are associated with VF before primary percutaneous coronary intervention (PPCI) is uncertain. Methods and Results All consecutive STEMI patients were identified in the Eastern Danish Heart Registry from

Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive tumors, accounting for around 5% of all soft tissue sarcomas. A better understanding of the pathogenesis of these tumors and the development of effective treatments are needed. In this context, established tumor cell lines can be very informative, as they may be used for in-depth molecular analyses and improvement of treatment strate

Background Some evidence suggests that chronic kidney disease is a risk factor for lower-extremity peripheral artery disease. We aimed to quantify the independent and joint associations of two measures of chronic kidney disease (estimated glomerular filtration rate [eGFR] and albuminuria) with the incidence of peripheral artery disease. Methods In this collaborative meta-analysis of international

Use of clay brick masonry in façades is often motivated by its aesthetic values and durability. Yet, mortar joints exposed to climate agents erode over time, expected to cause elevated moisture content and water absorption. Thus, it is often recommended that 40- to 50-year-old facades should be repointed – a measure which is intrusive and costly. Decision is in many cases taken without a clear evi

We introduce the 'Engineering Dwarfs at Galaxy Formation's Edge' (EDGE) project to study the cosmological formation and evolution of the smallest galaxies in the Universe. In this first paper, we explore the effects of resolution and sub-grid physics on a single low-mass halo (Mhalo = 109M⊙), simulated to redshift z = 0 at amass and spatial resolution of ∼ 20 M⊙ and ∼3 pc. We consider different st

Complement is crucial to the immune response, but dysregulation of the system causes inflammatory disease. Complement is activated by three pathways: classical, lectin, and alternative. The classical and lectin pathways are initiated by the C1r/C1s (classical) and MASP-1/MASP-2 (lectin) proteases. Given the role of complement in disease, there is a requirement for inhibitors to control the initiat

Background--Long-term disease progression after myocardial infarction (MI) is inadequately understood. We evaluated the pattern and angiographic properties (culprit lesion [CL]/non-CL [NCL]) of recurrent MI (re-MI) in a large real-world patient population. Methods and Results--Our observational study used prospectively collected data in 108 615 patients with first-occurrence MI enrolled in the SWE

Lund University has offered the Sida-financed International Training Programmeon Child Rights, Classroom and School Management since 2003. Theprogramme targets those in a position from which they can initiate processesof change in the education sector in their countries. During the programmeall participating teams initiate a change project in their respective countriesaiming at the realization of

Background A 1-h algorithm based on high-sensitivity cardiac troponin T (hs-cTnT) testing at presentation and again 1 h thereafter has been shown to accurately rule out acute myocardial infarction. Objectives The goal of the study was to evaluate the diagnostic accuracy of the 1-h algorithm when supplemented with patient history and an electrocardiogram (ECG) (the extended algorithm) for predicti

This paper presents a tool for computing thermal resistance of single U-tube ground heat exchangers placed in vertical boreholes. The tool is complete in the sense that it can compute both local and effective thermal resistances for either grouted or groundwater-filled boreholes. For grouted boreholes, it utilizes the highly accurate multipole method. For groundwater-filled boreholes, it utilizes

The past decade and a half has seen the design and execution of several ground-based spectroscopic surveys, both Galactic and Extragalactic. Additionally, new surveys are being designed that extend the boundaries of current surveys. In this context, many important considerations must be done when designing a spectrograph for the future. Among these is the determination of the optimum wavelength co

Bacteriophages present huge potential both as a resource for developing novel tools for bacterial diagnostics and for use in phage therapy. This potential is also valid for bacteriophages specific for Yersinia enterocolitica. To increase our knowledge of Y. enterocolitica- specific phages, we characterized two novel yersiniophages. The genomes of the bacteriophages vB_YenM_TG1 (TG1) and vB_YenM_φR

BACKGROUND: The ORBITA and ORBITA-2 trials have provided valuable insights into the effects of coronary revascularization in chronic coronary syndrome (CCS). However, uncertainties remain regarding the efficacy of revascularization on symptoms in large real-world populations. To evaluate the efficacy of revascularization, we used dispensed long-acting nitrates as a proxy for the presence of angina