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Immune checkpoint inhibitors (ICPI), such as ipilimumab [anti-cytotoxic T-lymphocyte antigen-4 (CTLA-4) antibody] and nivolumab or pembrolizumab [anti-programmed cell death protein-1 (PD-1) antibodies], improve survival in several cancer types. Since inhibition of CTLA-4 or PD-1 leads to non-selective activation of the immune system, immune-related adverse events (irAEs) are frequent. Enterocoliti
Today, simulation of springback has still not reached enough accuracy for acceptance as a production tool in the automotive industry. Further investigations need to be done in order to understand how to improve the results in an efficient way. In order to investigate which parameters that are important for the accuracy in a springback simulation, a parameter study of a U-shaped rail was performed.
The base (BOP) and the top (TOP) of the world income pyramid represent the poor people and the people from developed countries, respectively. About two-fifths of the world population can be categorized as poor. Poverty is a trap because children born to poor parents are likely to grow up to be poor adults. In recent years, a poverty reduction approach that combines business development with povert
Achieving rapid, intuitive, and error-free robot setup and instruction is a challenge. We present our work towards an assistive infrastructure for robot setup and instruction that attempts to address it. In this paper, we describe the ongoing development of a system that automatically generates multimodal dialogue interaction from product and process ontologies. The prototype currently generates t
In this work, we present a novel method for non-invasive identification of liquids, for instance to allow for the detection of liquid explosives at airports or border controls. The approach is based on a nuclear magnetic resonance technique with an inhomogeneous magnetic field, forming estimates of the liquid's spin-spin relaxation time, T2, and diffusion constant, D, thereby allowing for a unique
This study is done within the framework of a project aimed at developing a wearable device (a bracelet) intended to support sensory motor rehabilitation of children with visual impairments. We present an exploratory study of aesthetic/hedonistic preferences for sounds and touch experiences among visually impaired children. The work is done in a participatory setting, and we have used mixed methods
ECG markers derived from the P-wave are used frequently to assess atrial function and anatomy, e.g. left atrial enlargement. While having the advantage of being routinely acquired, the processes underlying the genesis of the P-wave are not understood in their entirety. Particularly the distinct contributions of the two atria have not been analyzed mechanistically. We used an in silico approach to
In this study, we assessed the proliferative response of peripheral blood mononuclear leukocytes (PBML) from 33 children/young adolescents with chronic dyspepsia, to H. pylori LPS in the presence and absence of IL-2 as a T cell growth factor. A rapid urease test (RUT) and a presence of Helicobacter-like organisms (HLO) in the biopsy specimens allowed us to distinguish RUT/HLO-positive (17/33) and
Autoantibodies to insulin (IAA) are one of the first markers of the autoimmune process leading to type 1 diabetes (T1D). While other autoantibodies in T1D have been studied extensively, relatively little is known about IAA and their binding specificities, especially after insulin treatment is initiated. We hypothesize that insulin antibodies (IA) that develop upon initiation of insulin treatment d
We present and discuss the Cs 3d X-ray absorption spectra and resonant photoelectron emission spectra of CsF. The resonant photoelectron spectra excited at the Cs 3d absorption maxima, exhibit a strong resonance behavior. The different behaviour of participator and spectator channels and interference effects of the 4d partial photoionisation cross-section at the 3d resonances are discussed. The ex
Today many methods are available for gas turbine flow path analysis. Some of them are very simple but yet very useful, since they give an indication of the compressor capacity with almost no calculation effort. The state of the art today is the heat and mass balance models (HMB), which are more sophisticated. This paper presents a general overview of these methods, including the most recent trend,
Histopathologic classification of cancer in the lung is important for choice of treatment. Cytokeratin 5 (CK5), p63, and p40 are commonly used immunohistochemical markers for squamous cell carcinoma, and napsin A (NAPA) and thyroid transcription factor 1 (TTF-1) are markers for adenocarcinoma of the lung. The aim of the present study was to evaluate these 5 markers and to compare different commerc
Sepsis is a life-threatening complication of infection that is characterised by a dysregulated inflammatory state and disturbed hemostasis. Platelets are the main regulators of hemostasis, and they also respond to inflammation. The human pathogen Streptococcus pyogenes can cause local infection that may progress to sepsis. There are more than 200 different serotypes of S. pyogenes defined accordin
Epidemiological studies have found that there is a correlation between red and processed meat consumption and an increased risk of colorectal cancer. There are numerous existing hypotheses on what underlying mechanisms are causative to this correlation, but the results remain unclear. A common hypothesis is that lipid oxidation, which occurs in endogenous lipids and phospholipids in consumed food,
Science Weeks tackled the great challenges of our time / page 8 Jubilee Course with a wow-factor / page 16 Some jubilee highlights / page 18 Lund University’s 350th anniversary – A LOOK BACK AT THE 13-MONTH YEAR 1 Lund University’s 350th anniversary celebrations ran between 19 Decem- ber 2016 and 28 January 2018, shin- ing a spotlight on the University’s education, research, innovations, external
https://www.lu.se/sites/www.lu.se/files/lund-university-350th-anniversary.pdf - 2026-05-29
Cardiac arrest causes an abrupt cessation of circulation, which rapidly leads to global ischaemia and hypoxia. Immediate and competent care is vital, and even when the circulation has been restored, there is a profound risk of patients never regaining consciousness due to hypoxic–ischaemic brain injury, or death due recurrent cardiac arrest or multiorgan failure. The complex pattern of symptoms se
