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Background: It is unclear whether thyroid hormone levels are associated with the risk of mortality, cardiovascular disease (CVD) events, or cancer in men with normal TSH. Objectives: We analyzed if serum free T4 (FT4) or TSH is associated with the risk of mortality, incident CVD events, or cancer in Swedish men. Methods: Elderly men (n = 1801; mean age 75 years) in the Gothenburg and Malmö subcoho

During the past few decades systemic corruption has come to be seen as a significant factor which hinders socio-economic development, posing a serious threat to the political, economic and social well-being of many developing and transition countries. Under conditions of systemic corruption, many institutions, rules and norms of behaviour have become adapted to a corrupt modus operandi. Public off

Toll-like receptor-4 activation by lipopolysaccharide (LPS) induces the expression of interferon-P (IFN-beta) in a MyD88-independent manner. Here we report that mice devoid of the JAK protein tyrosine kinase family member, Tyk2, were resistant to shock induced by high doses of LPS. Basal and LPS-induced expression of IFN-beta and IFN-alpha4 mRNA in Tyk2-null macrophages were diminished. However, T

Purpose of this paper The purpose of this article is to explore themes and challenges in making logistics environmentally sustainable with a complexity theoretical perspective. Design/methodology/approach The research is explorative and based on a cross-sectional design focusing on different entities of supply chains. The study set out with a systematic review and content analysis of articles in

Tertiary Lymphoid Structures (TLS) are organized aggregates of immune cells such as T cells, B cells, and Dendritic Cells (DCs), as well as fibroblasts, formed postnatally in response to signals from cytokines and chemokines. Central to the function of TLS are DCs, professional antigen-presenting cells (APCs) that coordinate the adaptive immune response, and which can be classified into different

Background and aims: Animal studies have suggested that high salt intake might increase the risk of metabolic dysfunction-associated steatotic liver disease (MASLD), but results from populations are mixed, in part due to inadequate salt intake measurement. Salty taste preference is the primary factor leading to salt choice and can reflect habitual salt intake. However, no study has investigated t

The digital healthcare market has been growing rapidly due to the swift development of wearable devices. One notable advancement is the application of digital healthcare technology to vehicles, which is expected to provide a comfortable driving environment and prevent accidents. This study proposed user experience (UX) scenarios to apply and expand digital healthcare technology in vehicles, detail

Jorunn Joiner and Mari Komnæs also employ digital tools, albeit other ones, to shed light on the interaction between narratives of exceptionalism, travel, and place. In ‘Mapping Nordic Exceptionalism with GIS: The Odin Migration Theory and the Search for a Northern Heritage’, they use digital mapping tools to visualise the journeys of two travellers from different centuries in their search for a N

Globular clusters host complex stellar populations whose chemical signatures suggest early (-) retention and reprocessing of stellar ejecta, yet direct evidence for intracluster gas is lacking. Here we present a unified theoretical framework for the evolution of gas in young globular clusters, and its implications for the production of multiple stellar populations. We show that low-velocity AGB wi

This dissertation examines the intense presence of the encounter with a number of artworks depicting sickrooms painted by Nordic artists by the end of the nineteenth century. To understand the intense presence enhanced through the encounter with these artworks, this dissertation argues that these paintings can be understood and examined as secular devotional images. Particular attention is devoted

Allergy, characterised by antibody responses of the IgE isotype, is a major health concern. The set of monoclonal human IgE used for studying the molecular mechanisms of allergies is limited. Single-cell sequencing offers opportunities to establish novel antibodies for researching, diagnosis, and treatment of allergies. We describe and exploit a pipeline for generating recombinant IgE directly fro

Abstract – Background: Cytological examination of a fine-needle aspirate (FNA) is a minimally invasive modality that is increasingly used in the diagnosis of lymphoma. Flow cytometry and other ancillary tests make an important contribution to the diagnostic value of FNAs of lymphoid lesions. This review follows the recent publication of the first edition of the WHO Reporting System for Lymph Node,

We present results of Population III (Pop III) formation in the megatron suite of simulations, which self-consistently follows radiation and non-equilibrium chemistry, and resolves gas at near-pc resolution in a Milky Way-mass progenitor at Cosmic Dawn. While the very first Pop III stars form in haloes with masses well below the atomic cooling limit, the majority of Pop III stars form in more mass

The quinoline-3-carboxamides (Q compounds) are a family of small molecules with immunomodulatory functions that have shown efficacy in various murine models of inflammatory diseases. One such compound has demonstrated antitumor effects in murine models. Q compounds bind to S100A9, thereby preventing its ligation to TLR4 and RAGE. S100A9 is a small molecule which has shown to have a role in the est

Biodegradable patches made of polyhydroxybutyrate (PHB) were recently shown to limit postoperative pericardial adhesions when inserted into the pericardium in sheep. The present study was carried out to evaluate the presence of post-operative retrosternal adhesions after cardiac surgery in patients operated on with the PHB patch compared with those operated on without the insertion of such a patch

Chemokines constitute a large family of low-molecular-weight proteins (∼10 kDa in size), recognized primarily for their role in directing leukocyte migration under both homeostatic and inflammatory settings. The chemokine CCL25 displays a unique and highly restricted expression pattern compared with other chemokine family members. In the steady state, CCL25 is expressed at high levels primarily in

Consumer goods manufacturers aiming to reduce the environmental impact associated with their products commonly pursue incremental change strategies, but more radical approaches may be required if we are to address the challenges of sustainable consumption. One strategy to realize step change reductions is to prepare a portfolio of innovations providing different levels of impact reduction in excha

AbstractShiga toxin (Stx) is the main virulence factor of enterohemorrhagic Escherichia coli (EHEC). EHEC strains cause gastrointestinal infection and release Stx that can gain access to the circulation. Patients may develop hemolytic uremic syndrome with extensive kidney damage. In the first paper we investigated if blood cell-derived microvesicles released during EHEC infection contain Stx. Toxi