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Technologies to develop and evolve the function of proteins and, in particular, antibodies have developed rapidly since the introduction of phage display. Importantly, it has become possible to identify molecules with binding properties that cannot be found by other means. A range of different approaches to create general libraries that are useful for the selection of such molecules specific for e

This dissertation is a collection of seven papers in which a number of questions are investigated regarding verbs that take a sentential complement as their direct object. These verbs are considered from different perspectives, namely from the perspective of the propositional attitude they express, or from the perspective of the syntactic construction they select, or from the point of view of the

A well-orchestrated inflammatory reaction involves the induction of effector functions and, at a later stage, an active downregulation of this potentially harmful process. In this study we show that under proinflammatory conditions the noncanonical Wnt protein, Wnt5a, induces immunosuppressive macrophages. The suppressive phenotype induced by Wnt5a is associated with induction of IL-10 and inhibit

Water uptake on aerosol and cloud particles in the atmosphere modifies their chemistry and microphysics with important implications for climate on Earth. Here, we apply an environmental molecular beam (EMB) method to characterize water accommodation on ice and organic surfaces. The adsorption of surface-active compounds including short-chain alcohols, nitric acid, and acetic acid significantly aff

Cardiac magnetic resonance (CMR) can quantify myocardial infarct (MI) size and myocardium at risk (MaR), enabling assessment of myocardial salvage index (MSI). We assessed how MSI impacts the number of patients needed to reach statistical power in relation to MI size alone and levels of biochemical markers in clinical cardioprotection trials and how scan day affect sample size.

This thesis work is on the theoretical description of dilute Bose-Einstein condensates (BEC) that are non-uniform, meaning that more than one single-particle state is occupied. This phenomenon is usually called quantum depletion. A common model for the ground state of a dilute and weakly interacting BEC is the mean-field (MF) approximation leading to the Gross-Pitaevskii (GP) equation. However, fo

This essay investigates the revolutionary strategy of the anarcho-syndicalists in Russia and Sweden before the World War I. The purpose of the research is to gain new knowledge about the relationship between the goal and the method from the point of view of the ideology of anarchosyndicalism. The study explores how the same ideology shaped strategy in two different national contexts. Publications

In 2018, images of migrant children held in cages and sleeping on concrete floors while being held in immigration detention in the United States shocked the world. Within the framework of the zero tolerance policy on immigration mandated by President Trump, thousands of families have been separated at the border. The trauma borne out of these separations was purposefully capitalized upon to serve

Knut Hamsun (1859-1952) is generally regarded as one of the first proponents of modern literature in Scandinavia. The present thesis discusses the author’s breakthrough phase which took place around the year 1890. This was an era when societal modernity became established in the Scandinavian countries, and new and revolutionary ideas and norms appeared concerning society, science, and art. Hamsun

Total levels of circulating prostate-specific antigen (tPSA) are strongly associated with prostate cancer (PCa) risk and outcome but benign prostate disease is the most frequent cause of a moderately elevated PSA level. Free PSA (fPSA) forms are independently associated with PCa risk and contribute modest diagnostic enhancements above and beyond tPSA alone. We developed an immunoassay for fPSA sub

In this study, a signal analysis framework based on the Karhunen-Loève expansion and k-means clustering algorithm is proposed for the characterisation of arteriovenous (AV) fistula’s sound recordings. The Karhunen-Loève (KL) coefficients corresponding to the directions of maximum variance were used as classification features, which were clustered applying k-means algorithm. The results showed that

TLR agonists are attractive candidate adjuvants for therapeutic cancer vaccines as they can induce a balanced humoral and T cell-mediated immune response. With a dense network of dendritic cells (DCs) and draining lymphatics, the skin provides an ideal portal for vaccine delivery. Beside direct DC activation, TLR agonists may also induce DC activation through triggering the release of inflammatory

Syftet med Dublinförordningen är att se till att asylansökningar behandlas av endast en medlemsstat, för att undvika fenomenen “asylsum shopping” och “refugees in orbit”. Förordningen består av en hierarki av kriterier för att fastställa vilken stat som är ansvarig, men detta har också lett till principen om ömsesidigt förtroende mellan medlemsstaterna, där alla stater förutsätts ha samma nivå av The purpose of the Dublin Regulation is to ensure that applications for asylum will be considered by one Member State, avoiding the phenomena of “asylum shopping” and “refugees in orbit”. The Regulation consists of a hierarchy of criteria for determining the responsible state, however, this has also resulted in the principle of Mutual Trust between Member States, where all states are presumed to h

Termen ”ekonomiskt våld” är för många ett relativt okänt begrepp, vilket bara under de senaste åren har börjat leta sig in i media och den allmänna samhällsdebatten. Bland forskare betraktas det ekonomiska våldet som mycket allvarligt och framför allt som en stor riskfaktor för att våldsutsatta kvinnor ska stanna i en våldsam relation. I svensk rätt finns inget straffbud som uttryckligen tar siktThe term “economic violence” is a concept that is relatively unfamiliar to many, which only in recent years has begun to find its way into the media and the general social debate. Many researchers regard economic violence as a very serious issue and, above all, as a major risk that may cause women that are victims of domestic violence to stay in a violent relationship. In Swedish law, there are n

Ambiguity and controversy abounds the debate over the thousands of people trying to enter the European territory and their rights, especially in their procedural form. This paper explores the latest developments in the context of the European Court of Human Rights’ and the European Court of Justice’s expansive interpretation of the right to an effective remedy and the procedural guarantees afforde

Detta arbete avser att kartlägga hur prövningen av 3 kap. 5 och 7 §§ fastighetsbildningslagen (1970:988) (FBL 3:5 och 3:7) har skett i lantmäteriförrättningar från 2004 fram till våren 2016, samt att kartlägga eventuella skillnader över landet. Slutsatserna från dessa frågeställningar väntas ge ett svar på huruvida prövningen eller lagstiftningen är i behov av förändring. En litteraturstudie har gThe Swedish Real Property Formation Act (1970:988), 3rd Chapter, 5th and 7th §§ (FBL 3:5 and 3:7) regulates protection of forested real property. The trial in practice have been investigated through an analysis of records of cadastral procedures performed in Sweden from 2004 to spring 2016. The most important conclusion of the investigation is that the trial is heterogeneous over the country. It h

Type 1 conventional dendritic cells (cDC1s) are rare immune cells critical for the induction of antigen-specific cytotoxic CD8+ T cells, although the genetic program driving human cDC1 specification remains largely unexplored. We previously identified PU.1, IRF8, and BATF3 transcription factors as sufficient to induce cDC1 fate in mouse fibroblasts, but reprogramming of human somatic cells was lim