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The work presented in this thesis has been focused on mesenchymal stem cells (MSCs). In the two first studies, the effects of MSCs on tumor growth and development in vitro and in vivo was investigated. In the third study the expression of the integrins alpha10beta1 and alpha11beta1 on MSCs was characterized and the involvement of these two integrins in cartilage development was investigated in vit
Popular Abstract in Swedish Varför skulle det vara mer europeiskt att rösta ja till Euron än vad det är att rösta nej? Varför går det inte att vara både populist och ?god europé? på samma gång? Vad skiljer en illegal invandrare från en vanlig turist? På vilka sätt avviker Europa från andra föreställda gemenskaper som exempelvis nationen? Avhandlingen ?bringing europe down to earth? (ung. ta ner euWhy is it considered more European to vote in the affirmative of the Euro than it is to vote against it? Why is not possible to be a populist and a ?Good European? at the same time? What makes an illegal immigrant different from a tourist? These questions all concern the limits of what it means to be, act and think as Europeans in Europe. In the political process of bringing the nations and people
Popular Abstract in Swedish Vad innebär politik efter det internationella? Många samtida perspektiv på internationell politik konvergerar i synen på 'det internationella' som en överspelad idé, men divergerar i synen på vilken typ av politik som växer fram i dess ställe. Den moderna staten har varit avgörande för betydelsen av säkerhet, territorialitet och auktoritet - begrepp konstituerande för iWhat does a politics after the international mean? Many strands of contemporary scholarship converge on the image of the international as obsolete, but strongly diverge on the contours of the kinds of politics that are superseding it. The modern state has been pivotal to the meaning of security, territory and authority?concepts central to the idea of the international?but they do not necessarily h
Popular Abstract in Swedish Många tolkningar och användningsområden har av olika forskare föreslagits för det gammaltestamentliga offret shelamin. Detta offer hade också en oklar plats i den israelitiska kulturen. Avsaknaden av konsensus och misslyckandet med att nå fram till en tillfredsställande lösning på gåtan gör shelamim till ett intressant offer att undersöka med hjälp av modern ritualforskFor the sacrifice shelamim in the Hebrew Bible, scholars have suggested a number of different interpretations and uses. This sacrifice also had an ambiguous role in Israelite culture. Lack of a general consensus and the failure to reach a satisfying solution makes the shelamim a puzzle and an interesting sacrifice to investigate with insights gained from modern ritual studies. In this study, it i
Allergic rhinitis is an inflammatory nasal disorder in which a range of different cells participates. A variety of approaches has been used to monitor nasal inflammation objectively to investigate disease processes and to evaluate the effect of therapeutic intervention. These approaches include nasal lavage, nasal cytology, and nasal biopsy, together with the more recently established measurement
The microarray technology has revolutionized biological research in the last decade. By monitoring the expression of many genes simultaneously, microarrays can elucidate gene function, as well as scan entire genomes for candidate genes encoding complex traits. However, because of high costs of sequencing and design, microarrays have largely been restricted to a few model species. Cross-species mic
The origins of allergic asthma, particularly in infancy, remain obscure. Respiratory viral infections and allergen sensitization in early life have been associated with asthma in young children. However, a causal link has not been established. We investigated whether an influenza A infection in early life alters immune responses to house dust mite (HDM) and promotes an asthmatic phenotype later in
We determined A/H1N1-HA antibodies in relation to HLA-DQ genotypes and islet autoantibodies at clinical diagnosis in 1141 incident 0.7-18 years old type 1 diabetes patients diagnosed April 2009 - December 2010. Antibodies to (35) S-methionine-labeled A/H1N1 hemagglutinin were determined in a radiobinding assay in patients diagnosed before (n=325), during (n=355) and after (n=461) the October 2009
BACKGROUND AND AIMS: Autoantibodies against the zinc transporter 8 (ZnT8A) are common in type 1 diabetes (T1D). ZnT8A analyses are complicated by the fact that there are three variants of the autoantigen at amino acid position 325 representing ZnT8-R (Arginine), ZnT8-W (Tryptophan) and ZnT8-Q (Glutamin). The aims of the study were: 1) to develop an autoantigen triple mix Radio-Binding Assay (RBA)
Aims To investigate vibrotactile sense (large fibre neuropathy) at different frequencies in index and little fingers (median and ulnar nerves, respectively) of subjects with diabetes, or impaired (IGT) or normal glucose tolerance (NGT). Methods Vibration thresholds (tactilometry at seven frequencies (8, 16, 32, 64, 125, 250 and 500 Hz)) and median nerve function (electrophysiology) were examined i
Popular Abstract in Swedish Avhandlingen är en historisk-komparativ analys av en konflikt som har uppstått i Miskito's ekonomiska system under 1900-talet avseende exploateringen av kommunalt ägda resurser. Studien är baserad på empiriskt material insamlat i en Miskito/Creole by på Atlantkusten i Nicaragua på 1990-talet. Under den s k enklavperioden (1860-1960) tjänade Miskito män pengar som lönearThis dissertation is a historical-comparative analysis of a conflict that has developed in the economic system of the Miskito in the 20th century, concerning the use of common property resources. The study is based on empirical material collected in a Miskito/Creole village on the Atlantic Coast of Nicaragua in the 1990s. During the enclave period (1860-1960) Miskito men earned money as wage labou
The conflict mineral crisis has been ongoing in the DRC for nearly two decades, with armed groups and increased military presence have played on the tin, tantalum, tungsten and gold to fund a brutal war across the eastern region of the country. Recent international efforts to tackle such illicit trade in conflict minerals has focused on requiring relevant stakeholders involved in the mineral sourc
Context:Patients with treated adrenal insufficiency (AI) have increased morbidity and mortality rate. Our goal was to improve outcome by developing a once-daily (OD) oral hydrocortisone dual-release tablet with a more physiological exposure-time cortisol profile.Objective:The aim was to compare pharmacokinetics and metabolic outcome between OD and the same daily dose of thrice-daily (TID) dose of
Chemotaxis inhibitory protein of Staphylococcus aureus (CHIPS) is a protein that binds and blocks the C5a receptor (C5aR) and formylated peptide receptor, thereby inhibiting the immune cell recruitment associated with inflammation. If CHIPS was less reactive with existing human antibodies, it would be a promising anti-inflammatory drug candidate. Therefore, we applied directed evolution and comput
Physical activity is beneficial for the health of persons with disabilities but the levels of such activity are lower than for persons without disability. In addition the level of physical activity decreases with increasing age. For persons aging with a disability it may be a challenge to engage in physical activity, partly because of the disability and partly because of contextual barriers. One g
BACKGROUND: Lead is an established causal risk factor for coronary heart disease. Atherosclerosis may be the key mediator for this association, but evidence from studies in humans is limited. Our objective was to test the hypothesis that environmental lead exposure is associated with coronary atherosclerosis. METHODS: We used cross-sectional data from the SCAPIS (Swedish Cardiopulmonary Bioimage S
