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Few germline mutations are known to affect lung cancer risk. We performed analyses of rare variants from 39,146 individuals of European ancestry and investigated gene expression levels in 7,773 samples. We find a large-effect association with an ATM L2307F (rs56009889) mutation in adenocarcinoma for discovery (adjusted Odds Ratio = 8.82, P = 1.18 × 10−15) and replication (adjusted OR = 2.93, P = 2
The master regulator of neuroendocrine differentiation, achaete-scute complex homolog 1 (ASCL1) defines a subgroup of lung adenocarcinoma. However, the mechanistic role of ASCL1 in lung tumorigenesis and its relation to the immune microenvironment is principally unknown. Here, the immune landscape of ASCL1-positive lung adenocarcinomas was characterized by immunohistochemistry. Furthermore, ASCL1
Vitamin D regulates parathyroid cell proliferation and secretion of PTH. Increased prevalence of the polymorphic vitamin D receptor (VDR) alleles b, a, and T has been reported in sporadic primary hyperparathyroidism (PHPT), suggesting that these genetic variants may predispose to the disease. Recently, another polymorphism in the VDR gene was related to bone mineral density, and this VDR-FokI poly
The intestinal epithelium is continuously exposed to deleterious environmental factors that might cause aberrant immune responses leading to inflammatory disorders. However, what environmental factors might contribute to disease are poorly understood. Here, to overcome the lack of in vivo models suitable for screening of environmental factors, we used zebrafish reporters of intestinal inflammation
BackgroundThis is the first nationwide segregation analysis that aimed to determine whether familial venous thromboembolism (VTE) is attributable to inheritance and/or shared environment, and the possible mode of inheritance.Methods and ResultsThe Swedish Multi‐Generation Register was linked to the Swedish patient register for the period 1964 to 2015. Three generational families of Swedish‐born in
The educational opportunities of refugee learners are shaped by forces of globalization, restrictive mobility regimes and geopolitical agendas, that place them in a position of structural disadvantage. The majority of the world's refugee learners have fled due to armed conflict and reside in neighboring countries in the global South. In many cases forced displacement is protracted, with limited gl
Attosecond pulses in the extreme ultraviolet (XUV) spectral range are today routinely generated via high-order harmonic generation (HHG), when intense ultrashort laser pulses are focused into a gaseous generation medium. The effect is most easily understood in a semi-classical picture [1]. An electron can tunnel ionize from the distorted atomic potential, pick up kinetic energy in the laser field,
In a seminar room at LUX, one of the buildings of the Joint Faculties of Humanities and Theology, a group of PhD students and senior scholars are in deep concentration in front of their computers. It is pin-drop silent in the room until the alarm goes off and everyone starts moving and talking. This is the writing group, an informal and voluntary way of working together in time slots with 45 minut
Professor Contact details Email: peter [dot] christiansen [at] fysik [dot] lu [dot] se Phone: +46 46 222 77 09 Mobile: +4531603012Organisation Particle and nuclear physics Room number: K240 Service point: 14 WebpagePeter Christiansens profile in Lund University research portalOther affiliations Member of Strategic Research Area eSSENCE: The e-Science CollaborationMy research focuses on determining
https://www.particle-nuclear.lu.se/peter-christiansen - 2026-05-30
Centre for Mathematica l Sc iences Div ision of Mathematics and Numerical Analysi s Course Analysis for MATA04 Mathematics for scientists 2, Autumn 2023 Course Information Lecturer: Evgeniy Lokharu Teaching assistants: Stefano Böhmer Number of students: 10 3 students answered the course evaluation, 10 of them are enrolled on program name. Examination Project: 9 students passed. Written examination
https://www.maths.lu.se/fileadmin/maths/Matematik_NF/Kursutvaerderingar/HT2023/MATA04HT23.pdf - 2026-05-30
Kursutvärdering Course: Mathematical statistics:MASA02 Evaluated on LTH: No Teachers:: Dragi Anevski and Stanislav Volkov Antal studenter: 57 Svarsfrekvens: 17/57 Summary: There are some mixed opinions about the course but overall it works reasonable well. Comments: Changes to next time: The course will be lectured by the sane person throughout to whole course. We think that this will give a more
https://www.maths.lu.se/fileadmin/maths/utbildning_education/Kursutv_HT24/KU_Matematisk_statistik_MASA02_HT24.pdf - 2026-05-30
Centre for Mathematical Sciences Faculty of Science Centre for Mathematical Sciences Division of Mathematics and Numerical Analysis Course Analysis for MATA32/ÄMAA02 Algebra and Vector Ge- ometry, Autumn 2025 Course Information Lecturer: Anna-Maria Persson Teaching assistants: PhD students: Anna Rockstroh and Jimmy Kornelije Gunnarsson, student employees Chi Chen Wong, Urszula Jedrzejak Akash Arju
https://www.maths.lu.se/fileadmin/maths/Matematik_NF/Kursutvaerderingar/HT2025/MATA32A__MAA02HT2025.pdf - 2026-05-30
Degree Project Course (Master ) VT 2023 Degree Project Course (Master students) Answer Count: 3 I have completed the Master´s Degree Project within I have completed the Master´s Degree Project within Number of responses Mathematics (course code MATM01) 1 (33.3%) Numerical Analysis (course code NUMM03) 0 (0.0%) Mathematical Statistics (course code MASM02) 2 (66.7%) Total 3 (100.0%) Mathematical
https://www.maths.lu.se/fileadmin/maths/Matematik_NF/Kursutvaerderingar/VT2023/MATM03VT23.pdf - 2026-05-30
Objectives: To examine whether the mix of community and institutional long-term care (ILTC) for people with dementia (PwD) in Europe could be improved; assess the economic consequences of providing alternative services for particular groups of ILTC entrants and explore the transnational application of the ‘Balance of Care’ (BoC) approach. Method: A BoC study was undertaken in Estonia, Finland, Fra
The anatomy, function and plasticity of the primary olfactory centre, the antennal lobe (AL), of the desert locust Schistocerca gregaria was investigated using a number of neuroanatomical and neurophysiological methods. Anatomical characterisation of the AL in a number of orthopteran species made it possible to deduce a model concerning the evolution of microglomeruli. These neuropil structures, c
Atmosfäriska partiklar (aerosoler) finns överallt i jordens atmosfär. Masskoncentrationen av dessa varierar kraftigt beroende på i vilken miljö man mäter. I stadsluft kan man uppmäta tiotals mikrogram per kubikmeter medan man i arktiska områden uppmäter nanogram per kubikmeter. Den kolhaltiga aerosolen utgör en betydande del av atmosfärsaerosolens massa och är känd för att påverka människors och dCarbonaceous aerosols are known to affect human health negatively and to affect the climate of Earth. As specific types of aerosols originate from specific sources, it is important to know the amount of aerosols emitted from each source. Aerosol source apportionment is an important tool in mitigating air pollution and improving air quality. The subject of this thesis was the evaluation and develop
