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Regular prophylactic treatment with factor VIII (FVIII) and factor IX (FIX) concentrates in hemophilia A and B, respectively, is introduced in early infancy and has resulted in dramatic improvement of the conditions. Recombinant FVIII and FIX concentrates have been available for > 25 years and have been modified and refined through the years; however, unfortunately frequent intravenous administrat
We have characterized 2 distinct mechanisms through which infectious agents may promote platelet adhesion and thrombus formation in flowing blood, thus contributing to the progression of disease. In one case, the process initiates when the integrin alpha(IIb)beta(3) mediates platelet arrest onto immobilized bacterial constituents that have bound plasma fibrinogen. If blood contains antibodies agai
Protein ADP-ribosylation is a reversible post-translational modification that regulates important cellular functions. The identification of modified proteins has proven challenging and has mainly been achieved via enrichment methodologies. Random mutagenesis was used here to develop an engineered Af1521 ADP-ribose binding macro domain protein with 1000-fold increased affinity towards ADP-ribose. T
Lymphocytes from human peripheral blood were separated by Countercurrent distribution (CCD) in a charged aqueous two-phase system composed of Dextran T 500 and polyethylene glycol 6000. Maximal responses to the T-cell mitogens phytohemagglutinin and concanavalin A were detected in a part of the distribution corresponding to the area where the highest percentage of E rosetting cells were seen. Anti
Group B Streptococcus (GBS) is a leading cause of invasive bacterial infections in human newborns. A key GBS virulence factor is its capsular polysaccharide (CPS), displaying terminal sialic acid (Sia) residues which block deposition and activation of complement on the bacterial surface. We recently demonstrated that GBS Sia can bind human CD33-related Sia-recognizing immunoglobulin (Ig) superfami
Recognising Displacement and Human Rights at the Global Platform on Disaster Risk Reduction - The Raoul Wallenberg Institute of Human Rights and Humanitarian Law Skip to content Search for: Search Button Home About Us Who We Are Our History About Raoul Wallenberg Our Theory of Change Staff Opportunities Annual Reports Whistleblower Our work What we do Multi-Disciplinary Research Higher Education S
https://rwi.lu.se/news/global-platform-disaster-risk-reduction/ - 2026-05-05
LU Holding AB 556500-1467 Box 117, SE - 221 00 Lund, Sweden, Visiting address The Spark, Medicon village, Scheeletorget 1, Lund Telephone +46 46-222 00 00 Internet www.innovation.lu.se 1 AÅ rsredovisning för LU Holding AB 556500-1467 Räkenskapsåret 2020-01-01 – 2020-12-31 Transaktion 09222115557446406774 Signerat BA, JA, SF, BN, HP, CW, CE, UR, ST, LW, ME LU Holding AB 556500-1467 Box 117, SE -
https://www.innovation.lu.se/sites/innovation.lu.se/files/2021-08/LU%20Holding%20a%CC%8Arsredovisning%202020.pdf - 2026-05-07
Background: A significant proportion of patients with asthma have persistent symptoms despite treatment with inhaled glucocorticosteroids. Objective: We hypothesized that in these patients, the alveolar parenchyma is subjected to mast cell-associated alterations. Methods: Bronchial and transbronchial biopsies from healthy controls (n = 8), patients with allergic rhinitis (n = 8), and patients with
Security for outsourced control applications can be provided if the physical plant is enabled with a mechanism to verify the control signal received from the cloud. Recent developments in modern cryptography claim the applicability of verifiable computation techniques. Such techniques allow a client to check the correctness of a remote execution. This article delivers a proof of concept for applic
Around 50 million people worldwide suffer from Epilepsy, making it one of the most common neurological diseases. Epilepsy is characterized by sudden intermittent seizures, often imposing profound social and physical limitations. More importantly, the risk of premature death in these patients is up to three times that of the corresponding healthy population. It is estimated that 30% of the populati
Den här artikeln är över 5 år gammal, och informationen kan därför vara inaktuell. Lunds universitet och avdelningen Forskningsservice bjuder in till mingel med några av de lundaforskare som erhållit ERC-anslag, det kanske mest prestigefulla forskningsanslaget i Europa. Minglet äger rum på Pufendorfinstitutet den 15 mars, klockan 16:00. ERC, European Research Council, tilldelar löpande ut anslag t
https://www.lu.se/artikel/lunds-universitet-bjuder-till-mingel-med-toppforskare - 2026-05-05
Den här artikeln är över 5 år gammal, och informationen kan därför vara inaktuell. 5G handlar inte bara om snabbare surf. En minst lika stor ”game changer” är att 5G gör mer kommunikation trådlös än idag. Forskaren Emma Fitzgerald listar prylarna som kan kopplas upp - och de tekniska utmaningar som först måste lösas för att förändringen verkligen ska hända. Teknikskiften förändrar samhället, hur v
https://www.lu.se/artikel/sa-blir-vardagen-tradlos-med-5g - 2026-05-06
F(ab) fragments imprinted surface plasmon resonance (SPR) chip was prepared for the real-time detection of human immunoglobulin G (IgG). In order to attach polymerization precursor on SPR chip, the SPR chip surface was modified with allyl mercaptan. F(ab) fragments of the IgG molecules were prepared by papain digestion procedure and collected by fast protein liquid chromatography (FPLC) system usi
Denna uppsats behandlar de konkurrensrättsliga skillnaderna i EU-rätt och amerikans rätt rörande patentpooler. Genom patentpooler ges företag möjlighet att gemensamt samla sina patent inom ett visst tekniskt område och tillsammans licensera dem. Genom poolning av patent ökar möjligheterna för snabb utveckling samtidigt som licenskostnaderna minskar då samtliga nödvändiga patent blir tillgängliga gThis thesis identifies the differences in the antitrust regulations concerning patent pooling within the EU and the U.S. Patent pooling enables firms to jointly licence their patents as a package, gathering patents that are necessary in order to produce a certain product. Patent pooling allows faster development at lower costs, since firms can attain all necessary patents through one single licens
Questions about institutional stability and change are critically important for any understanding of political institutions. The field of Historical institutionalism in political science has described, studied and theorized institutions for decades. One of the most recurring concepts utilized in the explanation of institutional stability is path dependence, describing theoretical and empirical mec
