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Proteolysis of purified IgGs by human and bacterial enzymes in vitro and the detection of specific proteolytic fragments of endogenous IgG in rheumatoid synovial fluid
A comparative in vitro survey of physiologically relevant human and microbial proteinases defined a number of enzymes that induced specific hinge domain cleavage in human IgG1. Several of these proteinases have been associated with tumor growth, inflammation, and infection. A majority of the identified proteinases converted IgG to F(ab')(2), and a consistent feature of their action was a transient
A Heterobimetallic FeIIIMnII Complex of an Unsymmetrical Dinucleating Ligand: A Structural and Functional Model Complex for the Active Site of Purple Acid Phosphatase of Sweet Potato
The heterodinuclear mixed-valence complex [FeMn(ICIMP)(OAc)(2)Cl] (1) {H2ICIMP = 2-(N-carboxylmethyl)-[N-(N-methylimidazolyl-2-methyl)aminomethyl]-[6-(N-isopropylmethyl)-[N-(N-methylimidazolyl-2-methyl)]aminomethyl-4-methylphenol], an unsymmetrical N4O2 donor ligand} has been synthesized and fully characterized by several spectroscopic techniques as well as by X-ray crystallography. The crystal st
Destructive effects of murine arthritogenic antibodies to type II collagen on cartilage explants in vitro
Certain monoclonal antibodies (mAbs) to type II collagen (CII) induce arthritis in vivo after passive transfer and have adverse effects on chondrocyte cultures and inhibit self assembly of collagen fibrils in vitro. We have examined whether such mAbs have detrimental effects on pre-existing cartilage. Bovine cartilage explants were cultured over 21 days in the presence of two arthritogenic mAbs to
Highly efficient CO2 and propylene oxide co-polymerization using Zn glutarate/Zn-Cr double metal cyanide composite catalyst
A highly active zinc glutarate-double metal cyanide (DMC) composite catalyst (ZnGA/Zn-CrDMC) was designed for the carbon dioxide (CO2) and propylene oxide (PO) copolymerization reaction. The composite catalyst was synthesized in a rheological phase reaction and characterized using Fourier transform infrared spectroscopy (FT-IR), powder X-ray diffraction (PXRD), and scanning electron microscopy (SE
Dissecting the properties of circulating IgG against streptococcal pathogens through a combined systems antigenomics-serology workflow
This study showcases an integrative mass spectrometry-based strategy combining systems antigenomics and systems serology to characterize human antibodies in clinical samples. This strategy involves using antibodies circulating in plasma to affinity-enrich antigenic proteins in biochemically fractionated pools of bacterial proteins, followed by their identification and quantification using mass spe
Automatic Landing without GPS
Sagem Défense et Sécurité (now Safran Electronics & Defense), a French space and defense company of the SAFRAN group, is working on the next generation of Unmanned Aerial System (UAS). This UAS features a fully automatic Unmanned Aerial Vehicle (UAV) equipped with a state-of-the-art navigation system. This navigation system relies mainly on a high-accuracy Inertial Measurement Unit (IMU) coupl
Changing the game - The effects of a radical logo rebranding strategy on the consumer-brand relationship in football
Purpose: The purpose of this thesis is to provide an understanding of how consumer-brand relationships are affected by a radical rebranding strategy of a football club’s logo. This further leads the paper to contribute to the literature of consumer-brand relationships in the special context of football. Methodology: The interpretative nature of this research calls for a qualitative research appro
Experimental determination of k Qfactors for two types of ionization chambers in scanned proton beams
Brandteknisk riskvärdering av Harry´s, Norrköping
Recurrent risk of hospitalization among older persons with problematic alcohol use: A multiple failure-time analysis with a discontinuous risk model
Background and AimsOlder persons with problematic alcohol use vary in psychosocial functioning, age of onset for problem drinking and use of other drugs. The study measured the differential risks of all-cause, alcohol, polydrug and psychiatric-related repeated hospitalizations among older persons with problematic alcohol use.DesignA linked register-based cohort study with discontinuous multiple-fa
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Sialylation of IgG antibodies inhibits IgG-mediated allergic reactions
rFIXFc prophylaxis improves pain and levels of physical activity in haemophilia B : Post hoc analysis of B-LONG using haemophilia-specific quality of life questionnaires
Research Cooperation With Iran Is Precarious
Swedish universities and colleges condemn the violence in Iran where security forces have fired at protesting students. Academic cooperation and exchange with Iranian universities, researchers and students can therefore be precarious according to Karin Aggestam and Ronny Berndtsson at the Centre for Advanced Middle Eastern Studies (CMES). Karin Aggestam is Director of CMES and Coordinator of the S
https://www.cmes.lu.se/article/research-cooperation-iran-precarious - 2026-05-05
New Thesis: Three questions for João Maria Jorge
Phase 1/2a clinical trial of BI-1206, an anti-CD32b (FcγRIIB) antibody, in combination with pembrolizumab in subjects with advanced solid tumors previously treated with anti-PD-1/PD-L1.
2593Background: PD-1 blockade has demonstrated positive anti-tumor activity across multiple tumor types. While the anti-tumoral response can be substantial and even curative, response rates remain low in many cancer types. Long-lasting responses are only observed in a minority of patients, and additional immunotherapeutic alternatives remain limited for patients who fail to respond or initially re
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Rött kort för sportswashing: En kvalitativ analys av Saudiarabiens nationsvarumärkning
Denna kandidatuppsats är en kvalitativ undersökning över hur länder i en rykteskris använder nationsvarumärkning och mjuk makt för att motverka negativa stereoty- per och förbättra sitt globala rykte. Nationsvarumärkning beskrivs som ett strate- giskt verktyg för att förbättra ett lands rykte och attraktivitet genom olika mark- nadsförings- och varumärkesmetoder. Flerstegsmodellen introduceras som
Vad kostar narkotikamissbruket? En studie av samhällets kostnader för narkotikamissbruk i Skåne 2006
Följderna av narkotikamissbruk kostar samhället stora summor pengar varje år. Att beräkna den exakta storleken på dessa summor är omöjligt, eftersom stora delar av den narkotikarelaterade verksamheten är olaglig. De kostnadsberäkningar man kan göra blir ungefärliga uppskattningar. Ändå är det viktigt att försöka, eftersom den kunskap man har om kostnaderna för narkotikamissbrukets konsekvenser utg
