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Combining histological grade, TILs, and the PD-1/PD-L1 pathway to identify immunogenic tumors and de-escalate radiotherapy in early breast cancer : A secondary analysis of a randomized clinical trial

Background The implementation of immunological biomarkers for radiotherapy (RT) individualization in breast cancer requires consideration of tumor-intrinsic factors. This study aimed to investigate whether the integration of histological grade, tumor-infiltrating lymphocytes (TILs), programmed cell death protein-1 (PD-1), and programmed death ligand-1 (PD-L1) can identify tumors with aggressive ch

De Gustibus and Disputes about Reference Dependence

Existing tests of reference-dependent preferences assume universal loss aversion. This paper examines the implications of heterogeneity in gain-loss attitudes for such tests. In experiments on labor supply and exchange behavior, we first measure gain-loss attitudes and then study a canonical treatment effect that distinguishes different models of reference dependence. We document substantial heter

Simultaneous 3D T1 and B1+ mapping at 7T using MPRAGE with multiple volumes and driven equilibrium (DE)

MP2RAGE has become popular for T1 mapping at 7T. Accuracy is yet improved by using a separately acquired flip angle map when creating the protocol-specific lookup table. Here, two additional volumes acquired at differing flip angles are added to an MP2RAGE sequence to obtain two separate states of driven equilibriums, effectively forming a dual flip angle protocol within the cycle. By estimating t

Outcry and Whisper (CN, EN, FR, DE & KO)

Shot over an eight-year period, Outcry and Whisper presents itself as a political manifesto for the resistance of women, be they workers, artists, intellectuals or militants, in Chinese and Hong Kong society. Their accounts shine a light on a ferocious battle for independence.

Evidence for De Novo Expression of Thymic Insulin by Peripheral Bone Marrow-derived Cells.

Thymic expression of insulin has been suggested to play a major role in negative selection of autoreactive T cells and tolerance induction against pancreatic beta cells. Furthermore, the expression of insulin in peripheral antigen-presenting cells (APC) has been clearly demonstrated but whether thymic negative selection and tolerance induction also depends on peripheral influx of self-antigens (Ag

På väg mot evidensbaserad terapi vid primär systemisk vaskulit. De senaste decenniernas framsteg har gett dagens patienter bättre läge

The prospects for patients suffering from systemic small vessel vasculitis have improved substantially in recent decades. The introduction of cyclophosphamide in the 1970s led to a dramatic improvement in survival rates. The discovery of ANCA meant a substantial increase in the number of detected cases, especially among elderly patients, as well as detection at an earlier stage of disease. At the