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BACKGROUND: Neutrophils and IL-17A have been linked mechanistically in models of allergic airways disease and have been associated with asthma severity. However, their role in pediatric asthma is unknown.OBJECTIVES: We sought to investigate the role of neutrophils and the IL-17A pathway in mediating pediatric severe therapy-resistant asthma (STRA).METHODS: Children with STRA (n = 51; age, 12.6 yea
RATIONALE: Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease characterized by lung epithelial cell injury, increased (myo)fibroblast activation and extracellular matrix deposition. Extracellular vesicles (EVs) regulate intercellular communication by carrying a variety of signaling mediators, including WNT proteins. The relevance of EVs in pulmonary fibrosis and their potential contribut
Sexual traits are often the most divergent characters among closely related species, suggesting an important role of sexual traits in speciation. However, to prove this, we need to show that sexual trait differences accumulate before or during the speciation process, rather than being a consequence of it. Here, we contrast patterns of divergence among putative male sex pheromone (pMSP) composi
The analysis of fossil chironomid and diatom assemblages from a sedimentary record from Les Roustières peat bog (Massif Central, France, 1196 m asl) allows the reconstruction of past environmental and climate changes during the late-glacial and early Holocene. Chironomid assemblages showed that the infilling of the palaeolake had commenced during the Oldest Dryas (GS-2b) as suggested by the rapid
The paper presents a study of key aspects in the design of a flexible unified data plane capable of integrating both fronthaul and backhaul transport in future 5G systems. In this study, we first review candidate access and multiplexing technologies from the state of the art and assess their capability to support legacy and new fronthaul and backhaul traffic. We then propose a new design framework
Background: Concerns have been raised about the quality of reporting in nutritional epidemiology. Research reporting guidelines such as the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement can improve quality of reporting in observational studies. Herein, we propose recommendations for reporting nutritional epidemiology and dietary assessment research by exte
Objective: To estimate and compare the lifetime risk of total knee replacement surgery (TKR) for osteoarthritis (OA) between countries, and over time. Method: Data on primary TKR procedures performed for OA in 2003 and 2013 were extracted from national arthroplasty registries in Australia, Denmark, Finland, Norway and Sweden. Life tables and population data were also obtained for each country. Lif
Protein S deficiency is a known risk factor for thrombosis. The coexistence of phenotypic type I (reduction in total and free antigen) and type III (reduction in free antigen only) protein S deficiencies in 14 of 18 families was recently reported. We investigated the cause of this phenotypic variation in the largest of these families (122 family members, including 44 affected individuals) using bo
Type III protein S deficiency is characterized by a low plasma level of free protein S, whereas the total concentration of protein S is normal. In contrast, both free and total protein S levels are low in type I deficiency. To elucidate the molecular mechanism behind the selective deficiency of free protein S in type III deficiency, the relationship between the plasma concentrations of β-chain con
Birth defects, which are in part caused by exposure to environmental chemicals and pharmaceutical drugs, affect 1 in every 33 babies born in the United States each year. The current standard to screen drugs that affect embryonic development is based on prenatal animal testing; however, this approach yields low-throughput and limited mechanistic information regarding the biological pathways and pot
We performed a large nested case-control study within the Finnish and Icelandic maternity cohorts to verify/falsify the association of maternal EBV infection with an increased risk of acute lymphoblastic leukemia (ALL) in the offspring found in previous studies. All hematologic malignancies diagnosed among children born during 1983 to 2006 in Finland and 1997 to 2005 in Iceland were identified thr
This thesis concerns the development of negation in the Italian L2 of a group of Swedish adults who live in Italy and acquire the language by formal and spontaneous learning. Various negative expressions and the verbal system were studied in a longitudinal analysis of a corpus with 29 recordings of seven subjects. The recordings consist mainly of spontaneous dialogue. While the development of the
The proposed experiments for the first RISING (Rare ISotope INvestigations at GSI) campaign will exploit secondary unstable beams at relativistic energies in the range from 100 MeV/u to 400 MeV/u. The RISING spectrometer will be employed for relativistic Coulomb excitation and for high-resolution gamma-spectroscopy experiments after secondary nucleon removal reactions and secondary fragmentation.
Gastric MUC5AC and MUC6 mucins were studied using polyclonal antibodies. Immunohistochemistry showed MUC5AC to originate from the surface epithelium, whereas MUC6 was produced by the glands. Mucins from the surface epithelium or glands of corpus and antrum were purified using CsCl/4M guanidinium chloride density-gradient centrifugation. MUC5AC appeared as two distinct populations at 1.4 and 1.3 g/
Wafer-level packaging (WLP) technology offers novel opportunities for the realization of high-quality on-chip passives needed in RF front-ends. This paper demonstrates a thin-film WLP technology on top of a 90-nm RF CMOS process with one 15-GHz and two low-power 5-GHz voltage-controlled oscillators (VCOs) using a high-quality WLP or above-IC inductor. The 5-GHz VCOs have a power consumption of 0.3
Systemic vasculitis associated with autoantibodies to neutrophil cytoplasmic antigens (ANCA) is the most frequent cause of rapidly progressive glomerulonephritis. Renal failure at presentation carries an increased risk for ESRD and death despite immunosuppressive therapy. This study investigated whether the addition of plasma exchange was more effective than intravenous methylprednisolone in the a
A comprehensive study of the molecular active landscape of human cells can be undertaken to integrate two different but complementary perspectives: transcriptomics, and proteomics. After the genome era, proteomics has emerged as a powerful tool to simultaneously identify and characterize the compendium of thousands of different proteins active in a cell. Thus, the Chromosome-centric Human Proteome
This paper presents a flexible architecture suitable for concurrent processing of multiple radio standards. The proposed architecture is based on a coarse-grained reconfigurable cell array, consisting of distinct processing and memory cells. Flexibility of the architecture is demonstrated by performing a coarse time synchronization and fractional frequency offset estimation for multiple OFDM stand
Some single-nucleotide polymorphisms are associated with higher risk of colorectal cancer development and are suggested to explain part of the genetic contribution to Lynch syndrome. Aim: To evaluate the mutL homolog 1 (MLH1) I219V polymorphism in 124 unrelated South American individuals suspected of having Lynch syndrome, based on frequency, association with pathogenic MLH1 and mutS homolog 2 (MS
Purpose: Plasma apolipoprotein M (apoM) is potentially anti-atherogenic, and has been found to be associated positively with plasma total, LDL and HDL cholesterol in humans. ApoM may, therefore, be intricately related to cholesterol metabolism. Here, we determined whether plasma apoM is affected by statin or fibrate administration in patients with diabetes mellitus. Methods: Fourteen type 2 diabet
