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Background: A medical treatment for urethral stricture (US) is not yet available. Objective: To evaluate if local injection of human adipose tissue-derived stem cells (hADSC) prevents urethral fibrosis in a rat model of US. Design, setting, and participants: Male rats were divided into three groups: sham, US, and hADSC (n = 12 each). Sham rats received a vehicle injection in the urethral wall. US
Many lines of evidence implicate mitochondria in phenotypic variation: ( a) rare mutations in mitochondrial proteins cause metabolic, neurological, and muscular disorders; ( b) alterations in oxidative phosphorylation are characteristic of type 2 diabetes, Parkinson disease, Huntington disease, and other diseases; and ( c) common missense variants in the mitochondrial genome ( mtDNA) have been imp
Doubly excited core-hole states of carbon monoxide in the photon energy region of 300-305 eV, i.e., directly above the C 1s ionization threshold, have been studied using both angle-resolved ion-yield and high-resolution resonant Auger spectroscopies. The leading configurations of the most prominent doubly excited Rydberg states are assigned by careful analysis of the ion-yield spectra and the fina
Purpose Postmenopausal women treated with corticosteroids are regarded as a high-risk group due to the effect of both natural bone loss and possible adverse effects of treatment with inhaled corticosteroids (IC). Objective To compare bone mineral density (BMD) in postmenopausal women exposed only to IC (IC group, n = 106) with that of BMD in women not exposed to corticosteroids (n = 124) and women
A BAC-array platform for comparative genomic hybridization was constructed from a library of 32,433 clones providing complete genome coverage, and evaluated by screening for DNA copy number changes in 10 breast cancer cell lines (BT474, MCF7, HCC1937, SK-BR-3, L56Br-C1, ZR-75-1, JIMTI, MDA-MB-231, MDA-MB-361, and HCC2218) and one cell line derived from fibrocystic disease of the breast (MCF10A). T
Objectives: During the last few years, clinical, epidemiological, and pathological evidence has suggested that inherited alpha-1 antitrypsin [AAT] deficiency might play a role in the development of the fibromyalgia syndrome [FMS], probably because of the loss of AAT anti-inflammatory efficacy. The objective of this study was to estimate the prevalence and number of FMS patients, and their AAT phen
Situated at the junction of Cognitive Semantics and Experimental Phenomenology, this study investigates how participants perceive the structure of 18 perceptual dimensions of opposites across the visual, auditory, tactile, gustatory and olfactory sensory modalities. The structures include three components: two poles (HIGH; LOW) and an intermediate (NEITHER HIGH NOR LOW). Participants were asked to
Medical, neurological, and substance use disorders constitute a major disease burden worldwide, but especially in low- and middle-income countries (LMICs) where more than 80% of affected persons are unable to receive evidence-supported treatments despite these being widely available in theory. This persistent mental health treatment gap in LMICs is traceable to the very nature of such nations: low
North Sea-Progressive Myoclonus Epilepsy (NS-PME) is a progressive neurological disorder, initially only associated with the homozygous GOSR2 founder mutation (c.430G>T; p.Gly144Trp). Clinical symptoms include untreatable early-onset ataxia, cortical myoclonus and epilepsy. Recently, the spectrum of GOSR2 mutations and associated phenotypic variability has expanded. To improve care and to facilita
INTRODUCTION: Postural orthostatic tachycardia syndrome (POTS) is a complex disorder with challenging diagnosis and management.METHODS: This cross-sectional, multi-national, web-based physician chart audit described clinical features and management of POTS, offering insights into disease burden and outcomes before and after the COVID-19 pandemic.RESULTS: Physicians (n = 153), primarily cardiologis
Body dysmorphic disorder (BDD) is frequently overlooked and untreated due to insufficient awareness and expertise in mental health settings. We developed a supervisor-supported online education programme to train clinicians in the assessment and treatment of young people with BDD and evaluated its feasibility and preliminary effects. Thirty clinicians working within child and adolescent mental hea
Background: In CIBIS III, initiating chronic heart failure (CHF) treatment with bisoprolol (target dose 10 mg q.d.) followed by combination therapy with enalapril (target dose 10 mg b.i.d.), compared to the opposite order, showed similar effects on survival and hospitalization. By echocardiography, we evaluated the effects of these treatment strategies on cardiac structure and function. Methods: I
Excessive vascular cell proliferation is an important component of pulmonary hypertension (PH). Perlecan is the major heparan sulfate (HS) proteoglycan in the vascular extracellular matrix. It binds growth factors, including FGF2, and either restricts or promotes cell proliferation. In this study, we have explored the effects of perlecan HS deficiency on pulmonary vascular development and in hypox
När biometriska metoder används för autentisering är det viktigt både att processen är korrekt, och går snabbt. Givetvis ska en obehörig användare inte kunna passera autentiseringsprocessen, och givetvis är det fördelaktigt om autentiseringen inte tar lång tid. Vid biometrisk fingeravtrycksigenkänning finns flertalet faktorer som försvårar matchningen. Brist på ljus kan göra fingeravtrycksbilden fThis thesis investigated the use of convolutional neural networks (CNNs) for image restoration of fingerprint images, focusing on the reconstruction from raw sensor images to denoised fingerprint images, suitable for matching. Fingerprint images from sensors often introduce noise and artifacts that inhibit the matching process. The goal was to develop a CNN-based approach capable of removing artif
Objectives: To examine powered mobility learning in children with spinal muscular atrophy (SMA) type I, involving families and evaluating goal attainment through the use of small, modified electric toy cars in the children’s natural environments. Design: Single-blind pilot intervention study derived from an originally planned wait-list randomized controlled trial. This report includes only the imm
In 1825, an unnamed Stellenbosch official paused his tax collection duties to pen a poem in the margins of the opgaafrol. His verses capture the frustrations of colonial administration but the records themselves–annual tax censuses spanning 1685 to 1844–offer a far richer window into the Cape Colony’s social and economic history. First established by the Dutch East India Company and later maintain
INTRODUCTION: Tourette syndrome (TS) and chronic motor or vocal tic disorder (CTD) are neurodevelopmental disorders associated with functional impairment and reduced quality of life. Behavioral therapy (BT) is an effective treatment, but lack of experienced practitioners makes it hard for patients to receive appropriate help. One approach to bridge the gap between demand and availability is to off
