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This perspective describes advances in determining membrane protein structures in lipid bilayers using small-angle neutron scattering (SANS). Differentially labeled detergents with a homogeneous scattering length density facilitate contrast matching of detergent micelles; this has previously been used successfully to obtain the structures of membrane proteins. However, detergent micelles do not mi

The purpose of this article is to evaluate the impact of university ecosystems on entrepreneurial intention and self-efficacy of Brazilian undergraduate students. The empirical exercise relies on Structural Equations Modelling based on data of 468 students from 70 universities across the country. Results indicate that traditional approaches to foment entrepreneurship are less effective than nurtur

The trophic structure of food webs is primarily determined by the variation in trophic position among species and individuals. Temporal dynamics of food web structure are central to our understanding of energy and nutrient fluxes in changing environments, but little is known about how evolutionary processes shape trophic position variation in natural populations. We propose that trophic position,

Aim: Ongoing climate warming has been widely reported to delay autumn phenology, which in turn impacts carbon, water, energy and nutrient balances at regional and global scales. However, the underlying mechanisms of autumn phenology responses to climate change have not been fully elucidated. The aims of this study were to determine whether brightening that was defined as the increase of surface so

Background: Current clinical decision rules to exclude deep vein thrombosis (DVT) are underused partly because of their complexity. A simplified rule that can be easily applied would be more appealing to use in clinical practice. Methods: We used individual patient data from prospective diagnostic studies of patients suspected of DVT to develop a new clinical decision rule. The primary outcome was

Unconventional ferroelectricity exhibited by hafnia-based thin films-robust at nanoscale sizes-presents tremendous opportunities in nanoelectronics. However, the exact nature of polarization switching remains controversial. We investigated a La0.67Sr0.33MnO3/Hf0.5Zr0.5O2 capacitor interfaced with various top electrodes while performing in situ electrical biasing using atomic-resolution microscopy

Cancer is a highly heterogeneous disease caused by dysregulation in different cell types and tissues. However, different cancers may share common mechanisms. It is critical to identify decisive genes involved in the development and progression of cancer, and joint analysis of multiple cancers may help to discover overlapping mechanisms among different cancers. In this study, we proposed a fusion f

The multiple-year drought that started in 2011 and reached climax in 2015 was the most severe and prolonged one in the semiarid northeastern (NE) Brazil in recent decades. This study aimed to investigate the reservoir surface water volume (SWV) variation in NE Brazil from 2009 to 2017 in four representative regions covering a total area of approximately 10,000 km2 there and encompassing 2,140 rese

In this study, novel asymmetric integral cation exchange membranes were prepared by the wet phase inversion of sulfonated polysulfone (SPSf) solutions. SPSf with different degrees of sulfonation (DS) was synthesized by variation in the amount of chlorosulfonic acid utilized as a sulfonating agent. The characterization of SPSf samples was performed using FTIR and1H-NMR techniques. SPSf with a DS of

Rearrangements of the transcription factors FOS and FOSB have recently been identified as the genetic driver event underlying osteoid osteoma and osteoblastoma. Nuclear overexpression of FOS and FOSB have since then emerged as a reliable surrogate marker despite limitations in specificity and sensitivity. Indeed, osteosarcoma can infrequently show nuclear FOS expression and a small fraction of ost

We report on the commissioning of an ultrafast timing diagnostic for measuring a time-offset signal between two different synchronized ultrashort light pulses. The method is based on sum-frequency generation in a nonlinear crystal. The setup is similar to an auto/cross-correlator setup. In this case, one of the beams is a relatively weak diagnostic beam of visible light from a bending magnet at Fe

Arabinoxylan (AX) with varying arabinose to xylose (A/X) ratios of 0.85, 0.57 and 0.39 was extracted from wheat bran, and the conformations of the AX polysaccharides dispersed in water were investigated using small-angle X-ray scattering. The persistence length (Lp) and the conformation statistics (expressed by the Flory exponent v or the mass fractal) of the AX varied with their A/X ratios. The L

Manganese tetra-pyridyl-porphyrins are found to self-organize in an ordered monolayer on graphene. Moreover, post deposition of cobalt ad-atoms steers the geometric reordering of the layer, yielding the formation of a self-assembled bimetallic network, where both Mn and Co are tetra-coordinated with nitrogen. While manganese shifts from Mn(ii) towards the +2/+3 oxidation state range, depending on

Activation functions are fundamental components in neural networks, enabling non-linear transformations essential for tasks like signal processing, control systems, image analysis, economics, and robotics. They play a crucial role in facilitating processes such as noise reduction, segmentation, and decision-making across various applications. Splines offer an alternative approach to traditional ac

Ionotropic glutamate receptors are tetrameric ligand gated ion channels that mediate in ux and ef ux of metal ions in response to glutamate. Positive allosteric modulators of the ionotropic glutamate receptor 2 (GluA2) are promising lead compounds for drugs against cognitive disorders. These compounds bind within the dimeric interface formed by the receptor ligand binding domains (LBDs) attenuatin

Since the last decade, development efforts by academia and industry for automated driving functions have increased significantly. Also, the European research project AdaptIVe is looking into this topic. Due to the large operation spaces and various complex situations that are covered by these functions, efforts for evaluation increase also significantly. Within AdaptIVe, a comprehensive evaluation

Chronic respiratory diseases remain a major cause of morbidity and mortality worldwide. The only option at end-stage disease is lung transplantation, but there are not enough donor lungs to meet clinical demand. Alternative options to increase tissue availability for lung transplantation are urgently required to close the gap on this unmet clinical need. A growing number of tissue engineering appr

Popular Abstract in Swedish Många olika proteiner kan produceras med hjälp av rekombinanta DNA tekniker. Ofta sätts vektorn som kodar för det rekombinanta proteinet in i bakterien E. coli, då den är välkänd. Det är viktigt att producera mycket celler för att uppnå hög produktivitet. Detta görs genom att näringsämnet (ofta glukos) tillsätts kontinuerligt till en så kallad semisats reaktor. TillsatsThe recombinant DNA techniques have made it possible to produce many different proteins for a wide range of applications. The vector encoding for the recombinant protein is often inserted in the bacterium E. coli as it is a well studied and a well-known organism. To achieve a high productivity, it is important to reach a high cell density. This is obtained through fed-batch operation where the nut

In this paper we outline a method for systematically addressing needs assessment (QUALISEM-PEOPLE), alongside a case study of its use within a medium sized, German company. The method was designed in order to provide guidance in analysing skill and role competences, particularly when e-learning systems are being considered for training purposes. The method proved to be successful within the compan