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Mechanisms of injury and repair in alveolar epithelial cells (AECs) are critically involved in the progression of various lung diseases including idiopathic pulmonary fibrosis (IPF). Homeobox only protein x (HOPX) contributes to the formation of distal lung during development. In adult lung, alveolar epithelial type (AT) I cells express HOPX and lineage-labeled Hopx+ cells give rise to both ATI an

Potential applications of genome editing in assisted reproductive technology (ART) raise a vast array of strong opinions, emotional reactions and divergent perceptions. Acknowledging the need for caution and respecting such reactions, we observe that at least some are based on either a misunderstanding of the science or misconceptions about the content and flexibility of the existing legal framewo

This article presents two formerly unedited travelaccounts, transcribed from the Swedish manuscripts and translated into English, narrating visits to Herculaneum, the Herculanense Museum and Pompeii, by Georg Fröman, Royal maçon, and Johan Tobias Sergel, sculptor, respectively. The texts are commented and put in historical context. Sergel's thorough accout of the Museum is read in parallel with th

Asparaginase is a mainstay of treatment of childhood acute lymphoblastic leukemia. Pegylation of asparaginase extends its biological half-life and has been introduced in the newest treatment protocols aiming to further increase treatment success. Hyperammonemia is a recognized side effect of asparaginase treatment, but little is known about its incidence and clinical relevance. Alerted by a patien

Background: Diagnosis of less common young-onset movement disorders is often challenging, requiring a broad spectrum of skills of clinicians regarding phenotyping, normal and abnormal development and the wide range of possible acquired and genetic etiologies. This complexity often leads to considerable diagnostic delays, paralleled by uncertainty for patients and their families. Therefore, we hypo

During fetal development, mammalian back-skin undergoes a natural transition in response to injury, from scarless regeneration to skin scarring. Here, we characterize dermal morphogenesis and follow two distinct embryonic fibroblast lineages, based on their history of expression of the engrailed 1 gene. We use single-cell fate-mapping, live three dimensional confocal imaging and in silico analysis

Objective: Estimates of pesticide exposure among applicators from low- and middle-income countries (LMICs) are scarce, and exposure assessment methods are sometimes costly or logistically unfeasible. We examined the variability in weeklong pesticide exposure among applicators in Costa Rica and its predictors.Methods: We conducted a cross-sectional survey among 221 pesticide applicators from organi

Paenibacillus larvae, causative agent of American Foulbrood (AFB), is the primary bacterial pathogen affecting honeybees and beekeeping. The main methods for controlling AFB are incineration of diseased colonies or prophylactic antibiotic treatment (e.g. tylosin), neither of which is fully satisfactory. The search for superior means for controlling AFB has led to an increased interest in the natur

This issue of the AILA Review focuses on transdisciplinarity as the key to developing shared languages in and across domains and professional settings. The relationship and collaboration between researchers and practitioners have long been discussed within and across applied sciences and theoretical disciplines, mainly in the framework of transdisciplinarity (see AILA Review 31, 2018, for a recent

The water-energy-food nexus is now a popular approach in the sustainability field. However, whereas the nexus calls for more holistic, inter- and transdisciplinary approaches, the research produced over the past decade has been fragmented and specialized. Furthermore, there is still a gap between the nexus as a descriptive and analytical concept and its operationalization. Nexus research needs a s

The ectomycorrhizal fungus Paxillus involutus decomposes proteins using a two-step mechanism, including oxidation and proteolysis. Oxidation involves the action of extracellular hydroxyl radicals (•OH) generated by the Fenton reaction. This reaction requires the presence of iron(II). Here, we monitored the speciation of extracellular iron and the secretion of iron(III)-reducing metabolites during

Uppsatsen avser kartlägga de poetologiska och poetiska kontaktytor som kan anas mellan den svenske poeten Öyvind Fahlströms konkreta poesi och den rumänsk-franske poeten Isidore Isous lettrism. Då man i tidigare forskning kring Fahlström och den konkreta poesins villkor ofta nämner Isou och det lettristiska avantgardet som poetologiskt närbesläktade, råder det vidare en brist i mer analytiska ansa

The Brazilian tax system is known to be very complex. The main reasons to that is presumably the fact that the federalist pact adopted by the Brazilian Federal Constitution gives a considerable autonomy to all federal entities (the federal government, the states, the Federal District and the municipalities) to impose levies. Besides that, the Brazilian tax system is composed by numerous levies, su

This thesis explores the sociomaterial dynamics involved in the migration process to a new library system, specifically focusing on the case of Quria, developed by Axiell and launched in 2017. Using a sociomaterial perspective the study examines how this technological transition affects the social structures within library organizations. The research is based on qualitative data collected through

Augmented reality (AR) is increasingly being adopted in fashion retail to enhance customer ex-perience, boost engagement, and reduce uncertainty in online shopping environments. While AR offers both hedonic and utilitarian value, its implementation across large multinational fashion companies remains inconsistent due to financial, technological, and organizational barriers. This study investigates

When an EU MS executes a state aid recovery decision, specifically those cases regarding Advance Pricing Agreements (APAs), an economic double taxation issue and a potential TP dispute may arise, which could be generated by the need for the application of a corresponding adjustment. In any case, each jurisdiction has the discretion to determine if the application of a corresponding adjustment shou

Denna uppsats behandlar ämnet religionsutövning i svenskt arbetsliv. Ämnet avhandlas dels utifrån perspektivet religionsfrihet som mänsklig rättighet, dels från perspektivet skydd och aktiva åtgärder mot diskriminering med religion som grund. Syftet är att göra en utredning i ämnet samt belysa frågan. Religionsfriheten stadgas i artikel 9 i Europakonventionen om de mänskliga rättigheterna och grun

Många missbrukare blir nyktra efter att ha varit på behandling och/eller självhjälpsrörelsemöten, såsom AA, där de arbetar utifrån riktlinjerna De Tolv Stegen. Kunskapen och förståelsen av programmet kan ses som ett livslångt lärande. Tidigare forskning har inte fokuserat på detta samband mellan lärande och nykterhet. Kvalitativa intervjuer har gjorts där fem nyktra beroende har berättat sin livsh