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Time policies, urban policies and planning

Over the past few decades, significant social and economic transformations had a relevant correspondence in processes of territorial complexification, urban fragmentation and spatial injustice. Literature and research shows that these processes have also a very important temporal dimension, associated to a transition from an industrial society of synchronized rhythms to more heterogeneous everyday

Visualization of Biomass Pyrolysis and Temperature Imaging in a Heated-Grid Reactor

The main advantage of a heated-grid reactor for studying pyrolysis kinetics of solid fuel samples is that high heating rates of up to 1000 K/s can be obtained. However, one of the concerns is whether the temperature distribution over the grid material is uniform and whether the presence of a thermocouple welded to the grid causes any measurement errors. Biomass samples were placed on the heated-gr

Identification of regulators of hematopoietic stem and progenitor cells in vivo in humans using population genetics

Introduction: Understanding how hematopoietic stem- and progenitor cells (HSPCs) are regulated is of central importance for the development of new therapies for blood disorders and for regenerative medicine. Traditionally, however, HSPC regulation has been studied in model systems, and little is known about the situation in vivo in humans. Methods: To learn how HSPCs are regulated under native con

Central nervous system metastases from epithelial ovarian cancer : Prognostic factors and outcome

Objectives: To analyze the clinicopathological characteristics and prognostic factors associated with survival in patients with central nervous system (CNS) metastases from epithelial ovarian cancer. Methods: Twenty patients with CNS involvement from ovarian carcinoma were evaluated in this retrospective study; their features and survivals were analyzed using Kaplan-Meier and log-rank test methods

Carcinosarcoma of the ovary : Analysis of 13 cases and review of the literature

Objectives: The aim of this study was to evaluate our experience with patients affected by ovarian carcinosarcoma. Patients and Methods: During a 16-year period, data on 13 patients with ovarian carcinosarcoma were collected. They were obtained from hospital charts and follow-up visits. Survival curves were estimated by the Kaplan-Meier method and compared using the log-rank test. All tests were t

Kärleksaffären : Kvinnor och köpenskap i kustens kommers

Det här är en avhandling om livsstilsbutiker och de handlare som driver dem. Livsstilsbutiker är affärer där olika produkter och tjänster erbjuds och gestaltas som helhetskoncept, ofta med hjälp av atmosfärskapande estetik. Med syftet att förstå hur livsstil görs till handelsföretagande beskriver och analyserar denna narrativa etnografi berättelser om och från livsstilsbutiker. Med utgångspunkt i This is a dissertation about life style boutiques and the shopkeepers who operate them. Lifestyle boutiques are shops where a variety of goods and services is offered and staged as an overall concept, often targeted to specific groups and tastes with atmosphere-creating aesthetics. Aiming to understand how lifestyle is made into retail enterprising, this narrative ethnography describes and analyse

Bootstrap-based bias correction and inference for dynamic panels with fixed effects

In this article, we describe a new command, xtbcfe, that performs the iterative bootstrap-based bias correction for the fixed-effects estimator in dynamic panels proposed by Everaert and Pozzi (2007, Journal of Economic Dynamics and Control 31: 1160–1184). We first simplify the core of their algorithm by using the invariance principle and subsequently extend it to allow for unbalanced and higher o

Targeted next-generation sequencing panels for monogenetic disorders in clinical diagnostics : The opportunities and challenges

Next-generation sequencing (NGS) will soon be used for clinically heterogeneous, inherited disorders and the increasing number of disease-causing genes reported. Diagnostic laboratories therefore need to decide which NGS methods they are going to invest in and how to implement them. We discuss here the challenges and opportunities of using targeted resequencing (TRS) panels for diagnosing monogene

Assessment of speech in early-onset ataxia : A pilot study

Aim: The aim of the study was to determine whether paediatric ataxia speech subscores are reliably applicable for international early-onset ataxia (EOA) databases. If so, we reasoned that ataxia speech subscores should be associated with ataxia scores and involve high interobserver agreement, including those for internationally applicable Scale for Assessment and Rating of Ataxia (SARA) syllable r

A sensitive and simple ultra-high-performance-liquid chromatography-tandem mass spectrometry based method for the quantification of d-amino acids in body fluids

d-Amino acids are increasingly being recognized as important signaling molecules in mammals, including humans. d-Serine and d-aspartate are believed to act as signaling molecules in the central nervous system. Interestingly, several other d-amino acids also occur in human plasma, but very little is currently known regarding their function and origin. Abnormal levels of d-amino acids have been impl

Myotonia in colchicine myoneuropathy

Colchicine may induce a myoneuropathy in patients with renal insufficiency. To date, myotonia has not been described in this disorder. We recently studied 4 patients treated with routine doses of colchicine who, in the setting of renal insufficiency, developed a severe myoneuropathy characterized by prominent myotonic discharges on electromyography. In addition, 1 of the 4 patients had profound cl

Practical management in Wolcott-Rallison syndrome with associated hypothyroidism, neutropenia, and recurrent liver failure : A case report

Wolcott-Rallison syndrome is a rare genetic syndrome of neonatal diabetes, liver failure, and growth retardation. We present a case with a EIF2AK3 p.(Arg902Ter) mutation, additionally complicated by hypothyroidism, impaired renal function, and exocrine pancreas insufficiency, focusing on clinical management. For its optimization, thorough care of multiple organ systems is needed.

Sex and gender publications in brain health : a mapping review of the Asia-Pacific region

INTRODUCTION: Reporting of sex and gender analysis in medical research has been shown to improve quality of the science and ensures findings are applicable to women and men. There is conflicting evidence on whether efforts by funding agencies and medical journals to encourage reporting of sex and gender analysis has resulted in tangible improvements. This study mapped the inclusion of sex and gend

Re-sequencing of the casein genes in Swedish Red cattle giving milk with diverse protein profiles and extreme rennet coagulation properties

Impaired rennet coagulation properties in milk could lead to prolonged processing times and production losses. Heritability for milk coagulation has previously been estimated to be 0.28 to 0.45, indicating that genetic selection can be used to manipulate this trait. The CN proteins are expressed by the genes CSN1S1, CSN2, CSN1S2, and CSN3 and are located on bovine chromosome 6. To better understan

Climate Shift : An Approach to Its Effects on the Rainfall Regime

Natural climate oscillations can cause extreme events such as floods and droughts. The mid-1970s is known for the occurrence of a global Climate Shift, defined as a short period when both interannual and interdecadal climate oscillations changed phases, which led the climate to a new state. Climate Shift has affected many regions and is considered an unprecedented event. In this chapter, we descri

Shedding new light on the Hubble constant tension through Supernovae Ia

The standard cosmological model, the ΓCDM model, is the most suitable description for our universe. This framework can explain the accelerated expansion phase of the universe but still is not immune to open problems when it comes to the comparison with observations. One of the most critical issues is the so-called Hubble constant (H0) tension, namely, the difference of about 5σ as an average betwe

Does clientelism pay off abroad? : Emigrant voting in Southern and Eastern Europe

Some political parties employ clientelist practices to gain voter support. Yet as more citizens now vote from abroad, little is known about parties engaging in clientelism domestically versus transnationally. We propose parties adopt either a replication or differentiation approach, meaning they apply similar or different campaigning strategies abroad. Using a large-N sample of voter turnout in So