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Colchicine may induce a myoneuropathy in patients with renal insufficiency. To date, myotonia has not been described in this disorder. We recently studied 4 patients treated with routine doses of colchicine who, in the setting of renal insufficiency, developed a severe myoneuropathy characterized by prominent myotonic discharges on electromyography. In addition, 1 of the 4 patients had profound cl
Wolcott-Rallison syndrome is a rare genetic syndrome of neonatal diabetes, liver failure, and growth retardation. We present a case with a EIF2AK3 p.(Arg902Ter) mutation, additionally complicated by hypothyroidism, impaired renal function, and exocrine pancreas insufficiency, focusing on clinical management. For its optimization, thorough care of multiple organ systems is needed.
Despite major advances in antibody discovery technologies, the successful development of monoclonal antibodies (mAbs) into effective therapeutic and diagnostic agents can often be impeded by developability liabilities, such as poor expression, low solubility, high viscosity and aggregation. Therefore, strategies to predict at the early phases of antibody development the risk of late-stage failure
Objective:Sleep duration has been related to overweight in children, but determinants of sleep duration are unclear. The aims were to investigate the association between sleep duration and childhood overweight adjusted for family characteristics and unhealthy behaviours, to explore determinants of sleep duration and to determine with sleep competing activities.Method:A cross-sectional study was ca
Lateralization is a fundamental property of the human brain that affects perceptual, motor, and cognitive processes. It is now acknowledged that left-right laterality is widespread across vertebrates and even some invertebrates such as fruit flies and bees. Honeybees, which learn to associate an odorant (the conditioned stimulus, CS) with sucrose solution (the unconditioned stimulus, US), recall t
Companies aiming to be 'sustainability leaders' in their sector and governments wanting to support their ambitions need a means to assess the changes required to make a significant difference in the impact of their whole sector. Previous work on scenario analysis/scenario planning demonstrates extensive developments and applications, but as yet few attempts to integrate the 'triple bottom line' co
The analysis of signals on complex topologies modeled by graphs is a topic of increasing importance. Decompositions play a crucial role in the representation and processing of such information. Here, we propose a new tight frame design that is adapted to a class of signals on a graph. The construction starts from a prototype Meyer-type system of kernels with uniform subbands. The ensemble energy s
I denna uppsats har jag velat undersöka om de prosodiska skillnaderna mellan svenskan och franskan kan förklara de avvikelser från den franska normen som återfinns hos nästan alla svenska inlärare av franska, i det närmaste oberoende av hur länge man har studerat språket. Jag ville studera om skillnaderna kunde härledas till olikheterna mellan de båda rytmiska språktyperna stress-timing och syllab
Den 5 februari 2016 införde Danmark den beryktade ”smyckeslagen” som bemyndigar den danska polisen att beslagta asylsökandens och andra utlänningars egendom för att täcka kostnader för deras försörjning, logi och hälsovård. Redan som lagförslag fick regleringen hård kritik och många menade att den kan stå i strid med egendomsskyddet i artikel 1 i tilläggsprotokoll 1 i europakonventionen om de mänsOn the 5th of February 2016, an act entered into force in Denmark that give the Police the right to confiscate asylum seekers’ and other aliens’ property in order to use them to cover costs that the authorities might have for their accommodation, health care and other living-costs. Before the act had formally passed, it was subjected to extensive critique. Some critics pointed out that the new leg
Disney har sedan 30-talet legat i täten för tekniska och artistiska landvinningar och har med sina filmer byggt en kanon som gjort bolaget synonymt med animerad film. Denna uppsats syfte är att undersöka de estetiska beståndsdelar Disneys filmer är uppbyggda av, där fokus ligger vid färgsättningen av de tecknade filmerna. Med hjälp av semiotisk stilanalys behandlas färganvändningarnas utseenden oc
Examensarbetet bygger på min egen översättning av ett utdrag ur den amerikanska författaren Mary Gaitskills roman ”Veronica” (2006). Uppsatsen inleds med en textanalys som stödjer sig på Hellspong & Ledins analysmodell (1997). Därefter följer en beskrivning av den globala imitativa och adekvansinriktade översättningsstrategi som använts för att uppnå estetisk ekvivalens och som bygger på Lita
This essays focus is to unravel the discourses concerning women by doing a historic-comparative qualitative content analysis on Malleus Maleficarum, written in 1486, and modern papal writings in order to compare the similar or different ways in which the ideal woman is understood. The reason for why these materials have been chosen is based on the influential spread these writing had or have, and
This essay explores the refugee’s access to human rights in regard to the case of Hirsi Jamaa and others v. Italy. The status of refugee, official or not, entails certain rights and state obligation, but the correlation between refugee rights and human rights is problematic. The analysis of the case parties’ arguments for and against violation of relevant articles of the European Convention for th
The thesis investigates how the problem of Critical Raw Material supply chains is represented within the European Critical Raw Materials Act of 2023. Bacchi’s ‘What's Problem Represented To Be’ approach has been adapted and utilised to explore what aspects of these supply chains are problematised. By highlighting how the problem of supply chains is represented, this research aims to uncover wh
The aim of this study was to establish whether or not a development of the complexity of the noun phrase, i.e. an increase in noun phrase elaboration could be observed in written L2 Swedish over time. To provide an insight to said development, three on L2 English previously tested and strongly correlating phrasal complexity measures, MLNP, MNPDep and WNPCx (Bulté 2013), were employed. A fourth mea
