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Seventy five percent of the world's food crops benefit from insect pollination. Hence, there has been increased interest in how global change drivers impact this critical ecosystem service. Because standardized data on crop pollination are rarely available, we are limited in our capacity to understand the variation in pollination benefits to crop yield, as well as to anticipate changes in this ser
Background. Whether disease burden in patients with metastatic castration-sensitive prostate cancer (mCSPC) predicts treatment outcomes is unknown. We assessed apalutamide treatment effect in TITAN patients with mCSPC by disease volume, metastasis number and timing of metastasis presentation. Methods. These protocol-defined and post hoc analyses of the phase III randomised TITAN study evaluated cl
Introduction: Galectin-3 is a pro-fibrotic β-galactoside binding lectin highly expressed in fibrotic liver and implicated in hepatic fibrosis. Selvigaltin (previously known as GB1211) is a novel orally active galectin-3 small molecule inhibitor that has high affinity for galectin-3 (human KD = 25 nM; rabbit KD = 12 nM) and high oral bioavailability in rabbits and man. In this study the efficacy of
Atrial fibrillation (AF) is the most common arrhythmia in the world, leading to a significant burden to patients and the healthcare system. It is characterised by rapid and irregular atrial contractions stemming from disorganised electrical activity in the atria. The atrioventricular (AV) node regulates heart rate during AF by filtering electrical impulses from the atria.However, for persistent AF
Background: Whether disease burden in patients with metastatic castration-sensitive prostate cancer (mCSPC) predicts treatment outcomes is unknown. We assessed apalutamide treatment effect in TITAN patients with mCSPC by disease volume, metastasis number and timing of metastasis presentation. Methods: These protocol-defined and post hoc analyses of the phase III randomised TITAN study evaluated cl
BACKGROUND: Concerns remain about the human reproductive toxicity of the widespread per- and polyfluoroalkyl substances (PFAS) during early stages of development. OBJECTIVES: We examined associations between maternal plasma PFAS levels during early pregnancy and male offspring reproductive function in adulthood. METHODS: The study included 864 young men (age range:18.9-21.2 y) from the Fetal Progr
In this study, the long-term mortality effects associated with exposure to PM10 (particles with an aerodynamic diameter smaller than or equal to 10 µm), PM2.5 (particles with an aerodynamic diameter smaller than or equal to 2.5 µm), BC (black carbon), and NOx (nitrogen oxides) were analyzed in a cohort in southern Sweden during the period from 1991 to 2016. Participants (those residing in Malmö, S
A building-integrated multifunctional PV/T solar window was suggested and developed by Andreas Fieber. The solar window is constructed of PV cells laminated on solar absorbers placed in a window behind the glazing. To reduce the costs of solar electricity, tiltable reflectors have been introduced in the construction to focus radiation onto the solar cells. The reflectors make it possible to contro
The overall aim of the work presented in this thesis was to evaluate the incidence, outcome and consequences within the 1st year of acute ACL injury of the knee. The KANON-study, a randomized controlled clinical trial comparing surgical and non-surgical treatment after acute ACL injury, was initiated and some results are included in this thesis. 642 subjects with acute knee injury were assessed in
This article investigates verb placement, especially verb second (V2), in post-puberty L2 learners of two closely related Germanic V2-languages, Swedish and German. Håkansson, Pienemann & Sayehli (2002) have adduced data from L1 Swedish-speaking learners of German in support of the claim that the syntactic property of V2 never transfers from the L1 to L2 interlanguage grammars. Regardless of L
Exposure to organic dust originating from biofuels can cause adverse health effects. In the present study we have assessed the dustiness in terms of microbial components and particles of various biofuels by using a rotating drum as a dust generator. Microbial components from straw, wood chips, wood pellets and wood briquettes were quantified by several methods. Excellent correllations (r greater t
Popular Abstract in Swedish Byggbranschen står inför stora utmaningar i att möta behovet av nya bostäder samtidigt som renoveringsbehovet av flerbostadshus är stort. Man beskylls ofta för bristande kvalitet och höga kostnader. Industriellt byggande har framförts som en lösning till problemen. I ett projekt på Lunds Universitet har två tillämpningar för industriellt byggande studerats: trähusbygganIndustrialized construction has over the years taken different expressions and gone through different phases depending on where inspiration has come from. In this project, industrialized construction has been studied in two applications: timber house manufacturing and renovation of multi-family houses. In Sweden industrialized production of timber houses is relatively strong in the housing sector
Introduction: Previous studies have demonstrated that common breast cancer susceptibility alleles are differentially associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. It is currently unknown how these alleles are associated with different breast cancer subtypes in BRCA1 and BRCA2 mutation carriers defined by estrogen (ER) or progesterone receptor (PR) status of the tumou
BACKGROUND: Maintenance of the botanical integrity of cereal kernels and the addition of acetic acid (as vinegar) in the product or meal has been shown to lower the postprandial blood glucose and insulin response and to increase satiety. However, the mechanism behind the benefits of acetic acid on blood glucose and satiety is not clear. We hypothesized that the gastric emptying rate could be invol
Introduction: Per- and polyfluoroalkyl substances (PFAS) concentration limits in drinking water have been decreased or are going to be decrease worldwide. Drinking water is the single largest input to our bodies, with 2-2.5 L/day for adults. However, current water treatment techniques are inefficient to remove PFAS from drinking water. Therefore, there is an urgent need to develop sustainable inno
Problem description: The case company, a packaging company in Lund, Sweden, operates in an industry where high productivity is becoming increasingly crucial to remain the industry leader. One of the most rapidly growing automating technologies today is RPA. The case company has adopted this technology. As of now the case company uses a centralized approach in implementing RPA which means that the
Vadhållningsutbudet på spelmarknaden är mångfacetterat. Det innefattar bland annat antalet gula kort och hörnor, måldifferensen med vilken ett lag ska vinna och resultatkombinationer som ackumulerar det totala oddset. För den som avser att manipulera en fotbollsmatch finns det således ett stort antal tillvägagångssätt. Oorganiserade aktörer gör överlag mindre insatser på spotbettingmarknaden utan As a result of the emergence and growth of the online gambling market, the number of betting markets available have increased vastly over the last years. As a consequence, match fixers frequently exploit the plethora of gambling objects and gambling forms on the gambling market in order to maximise winnings and minimise the risk of discovery. To limit the occurrence of manipulated matches in Swedi
The objective of this work was to develop a harmonised Life-Cycle Assessment methodology tailored specifically for assessing the environmental impact of daylighting systems. These systems include various architectural features, such as windows, skylights, or shading devices, designed to optimize the use of daylight in a space. This project aligns with the efforts to unify LCA practices within the
The Tam Giang-Cau Hai lagoon is located outside of Hue in central Vietnam. Southeast of Thuan An inlet, one of the two inlets of the lagoon, a groin was constructed in 2008 as a measure to reduce the sediment transport to prevent the inlet from closing. This groin has caused erosion of the eastern sand spit of the inlet and accretion of sediment on the coastline south east of the groin. The object
The demand for energy in the world is increasing steadily. As the standard of living for people in the developing countries is increasing so is the net energy use per capita. The main contributor to the energy consumption is the use of fossil fuels, which is also the major emission source for carbon dioxide. Carbon dioxide is in turn one of the most significant greenhouse gases and will enhance te
