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Human complement regulators are important targets for pathogenic microorganisms. In one such interaction, Bordetella pertussis binds human C4b-binding protein (C4BP), a high-molecular-weight plasma protein that acts as inhibitor of the classical pathway of complement activation. At least two different B. pertussis surface components, one of which is the virulence factor filamentous hemagglutinin (

Popular Abstract in Swedish Melatonin är ett hormon som produceras i, och frisätts från pinealorganet hos ryggradsdjur. Melatoninets viktigaste uppgift är att till hjärnan förmedla signalen om nattens längd, d.v.s vilken årstid det är. Produktionen och frisläppningen sker rytmiskt med den högsta nivån under natten. Melatoninet transporteras ut i kroppen via blodet och binder till särskilda mottaga

Aim: Many populations of migratory birds are currently declining. Understanding space use throughout the entire annual cycle, as well as migratory connectivity (i.e., geographic linkage of individuals and populations across different stages of the annual cycle), can improve our ability to identify factors driving population declines and influencing extinction risk. The main objectives of our study

Cocaine- and amphetamine-regulated transcript-derived peptides (CARTp) and corticotropin-releasing factor (CRF) alter feeding and gastrointestinal function after central administration, and the gastric inhibitory effects are mediated through CRF. We hypothesized that dorsal hindbrain effects of CARTp on gastric emptying are mediated by the vagus nerve and that the dorsal vagal complex (DVC) is a s

A decision is the result of comparing one or more alternatives with respect to one or more criteria that we consider relevant to the decision. Decision making can be considered as one of the most important challenges that analysts and experts encounter to solve complex problems. In recent decades, different methods and algorithms have been presented to support decision making. Multi-criteria analy

Glucose oxidase has wide applications in the pharmaceutical, chemical, and food industries. Many recent studies have enhanced key properties of this enzyme using directed evolution, yet without being able to reveal why these mutations are actually beneficial. This work presents a synergistic combination of experimental and computational methods, indicating how mutations, even when distant from the

Strontium isotope ratios in human teeth from the three Swedish prehistoric Stone Age hunter-fisher-gathering societies Norje Sunnansund (Maglemose), Skateholm (Ertebølle) and Västerbjers (Pitted Ware Culture) were analysed with laser ablation to produce data on both individual movement patterns and societal mobility trends. The analyses of teeth from both Skateholm and Västerbjers displayed homoge