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We conducted a multicentre, cross- sectional study of 1042 haemophilia subjects across Europe to compare various health outcomes associated with on-demand vs. prophylactic factor-substitution therapy. Demographic, medical history, and healthcare resource utilization data were analysed along with the number of bleeding events over the past 6 months. Treatment-cost data were also examined to provide
The number of copies of DNA in human cells can be measured using array comparative genomic hybridization (aCGH), which provides intensity ratios of sample to reference DNA at genomic locations corresponding to probes on a microarray. In the present paper, we devise a statistical model, based on a latent continuous-index Markov jump process, that is aimed to capture certain features of aCGH data, i
We present a fast vectorized implementation of a transform that maps points in the unit square to the surface of the sphere, while preserving fractional area. The mapping uses the octahedral map combined with an equal-area param- eterization and has many desirable features such as low distortion, straightforward interpolation, and fast inverse and forward transforms. Our SIMD implementation c
To prospectively study the prevalence of Lyme arthritis, 100 consecutive patients referred to a rheumatology out-patient clinic and 115 patients with a classified rheumatological disease were included. Individuals seropositive for antibody against the Borrelia burgdorferi sensu lato complex were examined for clinical signs or a history of Lyme borreliosis. Positive titres against B. burgdorferi s.
Molecularly imprinted polymers (MIPs) constitute a very appealing avenue to parallel sensors of a multitude of small target molecules due to their stability, relative ease of preparation, and their ability to recognize targets for which natural capture molecules do not exist. The authors present here a way of arraying MIP structures with micrometer dimensions, using nanofountain pen, and demonstra
Droplet sizes of oil/water (O/W) nanoemulsions prepared by the phase inversion temperature (PIT) method, in the water/C16E6/mineral oil system, have been compared with those given by a theoretical droplet model, which predicts a minimum droplet size. The results show that, when the phase inversion was started from either a single-phase microemulsion (D) or a two-phase W+D equilibrium, the resultin
Background: Craniopharyngioma is a parasellar tumour that, although benign, tends to behave aggressively. It can occur at any age but most commonly presents in childhood or adolescence. Objectives: to investigate the frequency and severity of problems associated with craniopharyngioma, using the large international database (KIMS) for adult patients with GH deficiency (GHD), and to assess the diff
Exhaled nitric oxide is a potential marker of lower airway inflammation. Allergic rhinitis is associated with asthma and bronchial hyperresponsiveness. To determine whether or not nasal and exhaled NO concentrations are increased in allergic rhinitis and to assess the relation between hyperresponsiveness and exhaled NO, 46 rhinitic and 12 control subjects, all nonasthmatic nonsmokers without upper
Lundblad A-M, Hansson K. Relational problems and psychiatric symptoms in couple therapyInt J Soc Welfare 2005: 14: 256 -264 c Blackwell Publishing, 2005.This article describes couples attending family counselling in Sweden. The study group is compared with clinical groups and non-clinical groups. Self-rating instruments were com-pleted by 317 women and 312 men to evaluate the following: marital sa
Objectives The aim was to psychometrically evaluate the Swedish version of the Multidimensional Pain Inventory (MPI-S) and the “brief screening version of MPI-S” for use in an elderly sample. Methods This study comprised 175 people aged 76–99 years reporting pain and in need of help to manage daily living. The instrument’s factor structures were investigated through factor analyses, convergent
Recently, a new class of copolymers, so-called protein-like copolymers has been predicted theoretically by computer simulation. In these copolymers. the conformation of the copolymer determines the exposure of certain comonomer units to the outer solution. Depending on the conformation, copolymer molecules with essentially the same comonomer composition could have pronouncedly different properties
Inert gas condensation (IGC) has been employed to produce nanoparticles of the low-temperature combustion catalyst CuOx/CeO2. For the first time we have used a multiple heating crucible setup to tailor various morphologies over the whole compositional range (2-98% Cu). The factors that control the growth, structure, and morphology of the nanocomposite have been studied. A powerful combination of c
Remodeling of photosynthetic machinery induced by growing spinach plants under low light intensities reveals an up-regulation of light-harvesting complexes and down-regulation of photosystem II and cytochrome b(6)f complexes in intact thylakoids and isolated grana membranes. The antenna size of PSII increased by 40-60% as estimated by fluorescence induction and LHCII/PSII stoichiometry. These low-
Disturbances in swallowing are common in neurologic disease but difficult to evaluate in the clinical setting. Fundamental variables such as bolus volume, swallow capacity (volume ingested over time), and the relation between ingestion and time for important events in oral and pharyngeal swallowing have not been sufficiently studied. We therefore employed a composite method for monitoring oral and
BACKGROUND: Middle-aged women experience various health-related problems. The aim of this study was to evaluate the impacts of menopause status and hormone intervention on women's health. METHODS: In an ongoing, population-based study, 4943 women, born 1935 to 1945 and living in the Lund area of Southern Sweden, were included in this analysis. They completed a generic questionnaire pertaining to s
We analyzed the concentration of I-129 in the water of 26 rivers covering most of the runoff from Sweden, with the aim of assessing current contamination levels, distribution patterns and potential sources in freshwater systems of northern Europe. The results show relatively high values (up to 1.4 x 10(9) atoms 1(-1)), steeply decreasing levels with increasing latitude and a positive correlation w
