Filetype
Our research We conduct research and education with a focus on disability and rehabilitation. The target groups are individuals of all ages with neurologic disabilities as a result of stroke, traumatic brain injury, spinal cord injury, post-polio, multiple sclerosis, Parkinson’s disease, and neuromuscular disorders, and children, adolescents and adults with non-malignant pain. The research group i
https://www.multipark.lu.se/rehabilitation-medicine - 2026-05-09
Our research In the gene therapy group, our main interest is to develop systems for sufficient and sustained expression of transgenes in the CNS. We are using gene transfer to express trophic factors or neurotransmitter-producing enzymes in animal models of neurodegenerative disease. We are currently working with three different vector systems: adeno-associated viral, retroviral and lentiviral. Th
https://www.multipark.lu.se/cns-gene-therapy - 2026-05-09
Lund Brain Injury laboratory for Neurosurgical research Our research Traumatic brain injury (TBI) is a common cause of death and disability and current treatment options are limited. TBI is also a risk factor for neurodegeneration and dementias. Beta-amyloid (Aβ) and tau aggregations, hallmark findings of Alzheimer´s disease, are also observed in TBI. Therefore, we explore the link between TBI, ag
https://www.multipark.lu.se/translational-neurotrauma-group - 2026-05-09
Our research We make images of the tissue microstructure using the MRI scanner. This could enable better diagnosis by detecting subtle changes in the organization of tissue at an early stage of the disease. The approach is based on diffusion MRI (dMRI), where water molecules probe tissue microstructure. Conventional dMRI yields metrics such as mean diffusivity and fractional anisotropy, regarded a
https://www.multipark.lu.se/multidimensional-microstructure-imaging - 2026-05-09
Our research The overall goal of the present project is to improve care and treatment as well as the quality of life for people with Parkinson's disease (PD). This will be done through improved detection, understanding, and treatment of the non-motor symptomatology in PD. We continuous monitor the PD symptomatology to improve our understanding for earlier detection. Further, we develop advanced PD
https://www.multipark.lu.se/restorative-parkinson-unit - 2026-05-09
Our research Organic Bioelectronic Neuropharmacology, electroceuticals for the nervous system - Our ambition is to supplement biochemical signaling with electronic functionalities using both galvanic (ion) and faradic (electron) processes. Traditional medicines are based on biochemical principles without regard to electrical properties. We focus on organic electronics that are self-assembled direc
https://www.multipark.lu.se/chemical-biology-therapeutics - 2026-05-09
Our research My group works with translational stem cell biology. The focus of my research is to understand cell fate specification in the developing brain and in human neural progenitor cells, using cell-based models of neuronal differentiation. Our current focus is to learn how to direct and efficiently drive controlled differentiation of human stem cells into subtype-specific neurons. We also d
https://www.multipark.lu.se/developmental-and-regenerative-neurobiology - 2026-05-09
Our research Neurovascular changes are now increasingly recognized as a common denominator of many neurodegenerative disorders. In my group, we examine how microvascular alterations at the blood-brain barrier contribute to the pathogenesis of neurodegeneration. Our special focus is on pericytes as key players in inflammation and neurodegeneration and potential target cells for brain repair. Using
https://www.multipark.lu.se/translational-neurology - 2026-05-09
Our research The Translational Neuroendocrine Research Unit (TNU) focuses on Huntington’s disease (HD). Furthermore, we study the spectrum of amyotrophic lateral sclerosis (ALS) and the behavioral variant of frontal temporal dementia (bvFTD). These are fatal neurodegenerative disorders without effective disease-modifying therapies. Although research has previously focused on the well-known disturb
https://www.multipark.lu.se/translational-neuroendocrinology - 2026-05-09
Our research Our group studies genetic causes of Parkinson’s disease (PD) and other neurological/neurodegenerative movement disorders. Emphasis presently lies on patients and families with inherited disease forms, where mutations in a single gene cause the disease. Such genetic disease forms offer the possibility to discover and study novel disease mechanisms. Genetic testing is increasingly used
https://www.multipark.lu.se/clinical-neurogenetics - 2026-05-09
Our research Research in the laboratory attempts to define pathogenic cellular and molecular mechanisms involved in synucleiopathies, in particular Parkinson's disease and multiple system atrophy, and Alzheimer's disease. Our work focuses on the interactions between glia and neurons. We are constantly developing new and robust human stem cell-based models which we utilize to understand cell autono
https://www.multipark.lu.se/stem-cell-laboratory-cns-disease-modeling - 2026-05-09
Our research Our research is focused on identifying cellular and molecular mechanisms contributing to circuit remodeling in the postischemic brain. In particular, we are interested in how the activation of dopamine signaling cascades modulates processes of adaptive neuronal plasticity. Identifying specific dopamine-driven targets may provide candidates for a recovery-enhancing adjuvant pharmacolog
https://www.multipark.lu.se/laboratory-experimental-brain-research - 2026-05-09
Our research We focus on finding protective factors for neurodegenerative disorders, with emphasis on Parkinson’s disease (PD). Our strategy is to identify risk factors in genes, lifestyle and environment, to learn about the underlying causes for disease, and how to interfere with these. In this quest, we combine molecular biology with in vitro and in vivo models and studies in clinical materials.
https://www.multipark.lu.se/translational-neurogenetics - 2026-05-09
Our research Our research centers on aging and neurodegenerative diseases. We aim to gain a better understanding of underlying disease mechanisms and aid in the development of better biomarkers for disease progression and clinical trials. We focus on characterizing the causes and effects of granular patterns of neurodegeneration, particularly in medial temporal lobe (MTL) subregions, which are sel
https://www.multipark.lu.se/medial-temporal-lab - 2026-05-09
Our research Our research uses reprogramming strategies to generate interneurons from novel cell sources with the aim to extensively define the subtype and function of these for therapeutic development, e.g. via interneuron cell replacement. For this, we are using reprogramming technology in animal models or human stem cell culture systems, together with electrophysiology, RNA sequencing, tracing
https://www.multipark.lu.se/regenerative-neurophysiology - 2026-05-09
A large collaborative project focused on understanding and treating dysfunctions of cortico-basal ganglia circuits in Parkinson´s disease (PD) has been awarded 35 million DKK from the Lundbeck Foundation. Angela Cenci Nilsson, coordinator of MultiPark, leads one of the three included research teams. Her group, the Basal ganglia pathophysiology, will conduct studies in animal models providing a bas
https://www.multipark.lu.se/article/new-transnational-collaboration-target-circuit-dysfunctions-parkinsons-disease - 2026-05-09
Our research We use Positron Emission Tomography (PET) to understand disease mechanisms and disease progression in neurodegenerative disorders. Our work focus on: 1) Parkinson’s disease (PD) and related “atypical” Parkinsonian Disorders. 2) tau PET imaging for diagnosis and tracking disease progression in Alzheimer’s Disease (AD) and other tauopathies such as Corticobasal Degeneration (CBD) and Pr
https://www.multipark.lu.se/neuropet-unit - 2026-05-09
A combination of two imaging methods can be used to achieve structural and chemical information within a single neuron. Researchers from MultiPark at Lund University recently developed this approach. Their study reveals that amyloid aggregates, implicated in Alzheimer’s disease, may cause clustering of iron in primary neurons. Alzheimer's disease is a major cause of dementia. Understanding where a
Amyloid-beta accumulation may start inside neurons. A novel imaging approach to study structural changes before amyloid plaques are formed. Four distinct subtypes of Alzheimer's disease. A simple diagnostic tool predicting the risk of developing the disease. And a collaboration with Region Skåne, Lund Municipality, and the pharma industry to facilitate earlier diagnosis and more accurate prognosti
https://www.multipark.lu.se/article/alzheimers-awareness-month-five-optimistic-research-news-multipark - 2026-05-09
A machine allowing researchers to rely on objective, automatized readouts instead of subjective manual counting under the microscope. Incredible pictures. And the possibility to follow live cellular events. The Operetta is the answer to these demands. The interest in using the new MultiPark infrastructure is big. In March, MultiPark received the new Operetta CLS instrument, upgrading the former Ce
https://www.multipark.lu.se/article/seven-tones-operetta-multiparks-new-high-content-analysis-platform - 2026-05-09
