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Background: This study evaluates deep learning (DL) using gene expression (GEX) and preoperatively available clinical data (PreopClinic) to predict sentinel lymph node macro-metastasis (SLNM), and explores their potential for guiding axillary surgery de-escalation and supporting prognostic assessment.Methods: We retrospectively included 6,836 clinically node-negative (cN0) T1-T2 patients with inva

Att sluta begå brott handlar inte enbart om förändrade handlingar, utan också om hur individer omformulerar vem de är. Denna avhandling analyserar hur unga personer med erfarenhet av kriminalitet konstruerar och förhandlar sina identiteter i berättelser om brottsdebut, fortsatt brottslighet och upphörande med brott. Avhandlingen behandlar tre centrala frågor: (1) Vilka innehållsmässiga komponenterIn this thesis I explore how young people with a criminal record choose to construct and negotiate their identities in narratives about debut offences, re-offending, and desistance. I address three key questions: (1) What content-related components are central to young people’s narratives of desistance? (2) What linguistic and cultural resources do young people draw on to present themselves as cre

Hemoglobin (Hb) can produce reactive oxygen species, including superoxide anions, which are intrinsically toxic. Superoxide dismutase (SOD) is present in red blood cells (RBCs) and provides important protection against such oxidative stress. Upon hemolysis, Hb becomes released from the RBCs and the normal protection systems involving SOD and catalase become very inefficient. In these instance

There has been active research in the development of new rigid biobased aromatic dicarboxylate monomers that can replace the widely used fossil-based dimethyl terephthalate in polyester production. In this work, a new biobased dicarboxylate monomer with a spiroacetal unit was synthesized from biobased vanillin and pentaerythritol, which aims to partially or completely replace the fossil-based

Durable and high-performing anion-exchange membranes (AEMs) are key components in alkaline water electrolyzers and fuel cells. As potentially more sustainable and cost-effective alternatives to proton exchange membrane (PEM)-based systems, AEM-based devices can operate without platinum-group metal catalysts or perfluorinated polymers. However, their broader practical implementation remains limited

We revisit the discussion on family limitation through stopping and spacing behavior both prior to and during the fertility transition. Using the birth histories of 13 519 settler women in nineteenth century South Africa we find no evidence of parity specific spacing prior to the transition. In addition we find no differences in spacing behavior based on differences in time invariant economic and

This study investigates the long-term social consequences of early-life exposure to adverseconditions in nineteenth-century Poznań. Using linked individual-level records from thePoznań Historical Population Database for birth cohorts 1830–1855, we examine howprenatal stress, infant mortality, early-childhood disease burden, and fluctuations in rye pricesinfluenced the likelihood of marriage and in

Bacteriophages exert strong selective pressure on bacterial populations and play a central role in shaping microbial evolution. In response to phage predation, bacteria have evolved diverse antiphage defence mechanisms that interfere with viral replication through a wide range of molecular strategies. Recent genomic studies have revealed a rapidly expanding repertoire of candidate defence systems,

BackgroundImmune-related hepatitis (ir-hepatitis) ranks among the most frequent adverse events of immune checkpoint inhibitors (ICIs). Limited knowledge exists regarding the incidence, characteristics, and treatment of patients having an inadequate response to initial therapy with steroids. Characterizing ir-hepatitis phenotypes and treatment responses can provide valuable insights for guiding tre

BACKGROUND AND PURPOSE: Pain as a long-term outcome following rectal cancer treatment has received limited attention in previous studies. This prospective cohort study examined pain prevalence up to 5 years post-surgery in patients treated with curative intent. Secondary aims included evaluating pain intensity and its interference with daily life, and comparing pain experiences with a reference po

The HLD-NAC (Hydrophilic-Lipophilic Difference - Net Average Curvature) equation of state is a powerful semi-empirical framework used to predict the phase behavior, solubilization, and interfacial properties of surfactant-oil-water (SOW) systems it is based on the assumption of a normalized curvature for an idealized microemulsion, represented as the coexistence of two fictitious phases: water dro