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The pathogenic mechanisms leading to neurodegeneration in Huntington disease (HD) are not fully understood but involve accumulation of toxic mRNA and protein products in the brain. Recent studies described an unconventional autophagic pathway involving DNA and RNA degradation through DNautophagy and RNautophagy that is regulated by the lysosomal protein SID1 transmembrane family member 2 (SIDT2).
Context. While the influence of the LMC on Milky Way (MW) stellar streams has been extensively studied, streams associated with the Clouds have received far less attention. Beyond the Magellanic Stream, only four stream candidates (S1–S4) have been reported. Aims. We focus on the S3 stream, a long (~30°) and narrow (~1.2°) structure at 60–80 kpc that is nearly aligned with the LMC. Our goals are:
Hedgehog (Hh) signaling is essential for embryonic development and tissue homeostasis in organisms. However, Caenorhabditis elegans lacks canonical Hh signaling due to the absence of key components, such as smoothened (SMO) and obvious Hh ligands. Despite this, C. elegans retains Patched homologs, ptc-1 and ptc-3, which have specialized independent functions. Although ptc-1 is predominantly ex
Den 9 april 2025 presenterade Miniminivåutredningen sitt delbetänkande SOU 2025:31, i vilket förslag bland annat lämnades på begränsningar i rätten till offentligt biträde i asylprocessen. Förslagen har sin grund i EU:s migrations- och asylpakt, mer specifikt den nya asylprocedurförordningen. Medan förordningen förespråkar en effektiv process som värnar om de asylsökandes rättigheter, är förslagenOn April 9th 2025, the so called Miniminivåutredningen presented its report SOU 2025:31, in which proposals were made, among other things, on restrictions on the right to be represented by a public legal counsellor through-out the asylum process. The proposals are based on the EU’s Migration and Asylum Pact, and more specifically the new Asylum Procedure Regulation. While the Regulation intends on
Purpose: Reduced rapid-eye movement (REM) sleep has been linked to increased mortality in the general population. We investigated whether diminished REM sleep is associated with higher mortality in adults with coronary artery disease (CAD) and obstructive sleep apnea (OSA). Methods: This secondary analysis of the RICCADSA trial included 356 revascularized CAD patients with OSA (apnea–hypopnea inde
Time- and Angle-Resolved Photoelectron Spectroscopy (tr-ARPES) is employed to monitor photoexcited electrons in the 2D hybrid perovskite (BA) (Formula presented.) (MA) (Formula presented.) (Formula presented.) (Formula presented.). Photoelectron intensity maps are in good agreement with ab-initio calculations of the band structure. The effective mass is (Formula presented.) and (Formula presented.
Background: Bile leakage is a severe complication after cholecystectomy and is associated with an increased risk of morbidity and mortality. The aim of this study was to evaluate the incidence of bile leakage post-cholecystectomy and to identify potential risk factors and their association with changes in the incidence of bile leakage over time. Methods: Demographic and perioperative data of all p
Light-emitting diodes (LEDs) are widely applied in fields ranging from solid-state lighting and high-resolution displays to optical communication and sensing. Despite their remarkable technological development, conventional thin-film LEDs remain constrained by strain-induced defects from lattice mismatch and restricted light extraction efficiency due to total internal reflection. Exploration of al
Let f be an entire function of finite exponential type less than or equal to σwhich is bounded by 1 on the real axis and satisfies f(0)=1. Under these assumptions, Hörmander showed that f cannot decay faster than cos(σx) on the interval (-π/σ,π/σ). We extend this result to the setting of de Branges spaces with cosine replaced by the real part of the associated Hermite–Biehler function. We apply th
Transient activation of fibroblasts into contractile myofibroblasts is essential for extracellular matrix (ECM) production and remodeling during wound healing and tissue regeneration. While ECM-dependent mechanisms mediating transient activation is well studied, how fibroblasts switch from transient to a persistently activated state and drive fibrosis and aberrant tissue repair in diseases such as
Group A Streptococcus (GAS) causes extensive global morbidity and rising rates of invasive disease, for which clinical outcomes remain poor despite antibiotic treatment of susceptible strains. This limitation of current therapy underscores the need for alternative or adjunctive approaches. Antibody-based interventions represent a promising but underexplored strategy. Historically, the streptococca
In this chapter, the occupational trajectories of a group of home-based seamstresses living in Gothenburg in 1912 is followed. Many studies dealing with gendered differences in labour market outcomes in the early twentieth century suggest that women’s choices most often followed a strategy based on the notion they would spend a short amount of time in their occupations and hence did not invest in
Universities support their teaching staff to develop contemporary teaching compe-tencies, yet institutional priorities may not align with those of staff. This study ex-amined open texts from 863 teaching staff from 16 departments at a research-inten-sive university to discover self-identified teaching competency needs. Five universal priorities were identified (student engagement, course developme
The current entry summarizes research bringing together the linguistic relativity hypothesis (the idea that language affects thought, in predictable ways) and the field of bi/multilingualism, broadly conceived to include learning, knowledge, and use of more than one language. After a brief historical introduction, the entry covers empirical research conducted in five main domains of enquiry, namel
This article investigates social media users’ attitudes towards Swedish dialects. It presents an analysis of 778 comments from Facebook and TikTok reacting to five short videos featuring a girl speaking a dialect typical of Värmland on Swedish national television. The analysis reveals that most comments express positive evaluations, describing the dialect as underbar ‘wonderful’, härlig ‘lovely’ a
BackgroundLongitudinal data on weight change, its timing, and the age of obesity onset in relation to cause-specific mortality are limited.MethodsFrom ODDS, a nationwide pooled cohort study in Sweden, we included 258,269 men and 361,784 women with at least three weight assessments between ages 17 and 60, collected in 1963–2015. We applied linear mixed-effects models to estimate weight trajectories
