Search results

Proteins and peptides are vital biomolecules, and deuterated amino acids are increasingly applied in areas such as drug discovery, metabolic tracing, and neutron scattering studies. In this study, we performed deuteration on all 20 proteinogenic amino acids, including their side chains, and established efficient methods for 13 amino acids. Using a Pt/C-catalyzed hydrogen–deuterium exchange reactio

People often feel less empathy towards outgroup compared to ingroup targets. Overcoming this intergroup empathy bias is important for fostering positive intergroup relations. In five pre-registered and high-powered online studies (n = 4776 (745/745/1056/1236/994)), we attempted to replicate and generalize motivated empathy interventions that previously have made people more empathetic and prosociaPeople often feel less empathy towards outgroup compared to ingroup targets. Overcoming this intergroup empathy bias is important for fostering positive intergroup relations. In five pre-registered and high-powered online studies (n = 4776 (745/745/1056/1236/994)), we attempted to replicate and generalize motivated empathy interventions that previously have made people more empathetic and prosocia

Background: Large bone defects are challenging to manage clinically and usually require treatment with bone graft or bone graft substitute. This study evaluated the effect of romosozumab, a sclerostin antibody, in combination with demineralized bone matrix (DBM) on bone regeneration in a critical-size ulnar defect model in nonhuman primates. Methods: In cynomolgus monkeys (N = 22, male, 10–12 year

Epithelial tissue fusion requires coordinated molecular events at the ends of two epithelial structures. Regulatory mechanisms controlling these events remain largely elusive. In the Drosophila reproductive system (RS), this fusion unites the gonad and the genital disc-derived tissues, into a continuous tube. This study unveils the pivotal role of Hamlet (Ham), a Drosophila PR domain containing

The premiere of the film National Pride: From Jericho to Gaza (Fierté Nationale: De Jéricho vers Gaza) was held at Visions du Réel in Nyon, Switzerland, April 8, 2025.

In many tasks, participants are instructed to fixate a target. While maintaining fixation, the eyes nonetheless make small fixational eye movements, such as microsaccades and drift. Previous work has examined the effect of fixation point design on fixation stability and the amount and spatial extent of fixational eye movements. However, much of this work used video-based eye trackers, which have i

Background: Acute myocardial infarction (AMI) is a leading cause of morbidity and mortality worldwide. Circulating endothelial cells (CECs) have been reported to be involved with the early stages of AMI. The specific objective of our study was to discover early diagnostic markers of CECs in circulation using bioinformatics analysis. Methods: Raw microarray data of the GSE66360 dataset were acquire

The aim of this study was to rank the rate and risk ratio of subject injury following exposure to less-lethal force modalities in real-life police interventions. The purpose was to observe whether the use of conductive electrical weapons (CEW) qualifies as a low-risk modality of force, with a similar risk of adverse health outcomes as exposure to other less-lethal modalities, such as physical forc

Background: The association between different patterns of healthcare use and non-recovery in patients with spinal disorders is unclear. We aimed to assess the association between healthcare use and non-recovery 6 months after a specialist evaluation in Norwegian secondary care and whether non-recovery was linked to adherence to specialist-recommended care. Methods: This observational registry-base

Background: Prolonged time to surgery (TTS) after neoadjuvant chemoradiotherapy (nCRT) may enable malnourished oesophageal cancer patients' nutritional status to recover better, possibly improving outcomes with fewer complications and better overall survival (OS) after oesophagectomy. Methods: This is a substudy within a multicentre randomised controlled trial comparing outcomes in patients with o

Understanding how organisms detect environmental humidity remains a fundamental problem in sensory biology. While specialised sensory neurons in insect antennae can detect changes in humidity, the mechanism underlying this ability is not fully understood. Here, we present an integrated approach combining precise humidity control, rapid cryo-preservation, and serial block-face scanning electron mic

Cities today grapple with crises of inequality, governance, and environmental challenges. Scholarship must also adapt to these evolving issues by developing new practices and generating relevant scholarship. This article examines a case of ‘social extremis’—severe socio-political conditions that threaten or limit life—and explores social practices that challenge such conditions. The study focuses

Background/Objectives: Irritable bowel syndrome (IBS) is presented with both gastrointestinal and extraintestinal symptoms. In addition, overweight/obesity and metabolic syndrome is prevalent in IBS. Dietary interventions with a low content of fermentable oligo-, di-, and monosaccharides and polyols (FODMAP) or a starch- and sucrose-reduced diet (SSRD) efficiently reduce symptoms and weight. Our h

The Economic Dispatch Problem (EDP) plays a critical role in power system operations by trying to allocate power generation across multiple units at minimal cost while satisfying complex operational constraints. Traditional optimization techniques struggle with the non-convexities introduced by factors such as valve-point effects, prohibited operating zones, and spinning reserve requirements. Whil

The retinoblastoma gene (RB1), which is located on chromosome 13q14.2, is mutated in retinoblastoma (RB), the most common malignant intraocular tumor in children. About 8000 new cases of retinoblastoma are diagnosed globally each year, accounting for approximately 1 in 17,000 live births. RB is prototypically considered hereditary by nature as thirty to forty percent of cases have autosomal domina

Context. The analysis of precise Gaia DR3 astrometry in the LMC region has revealed asymmetric patterns in the bar quadrupole and the disc outskirts of the LMC in-plane velocity maps. Aims. We aim to quantify the asymmetries detected in the LMC radial and residual tangential velocity maps, and determine whether they are generated naturally due to the LMC’s interaction with the SMC. Methods. We ana

Brain metabolism is a fascinating and exciting research topic. Many new metabolic features of the brain continue to be unveiled and much remains to be discovered. To truly enable scientific progress, it is imperative that discoveries and theories are continually challenged through scholarly discussion. Here we address an earlier editorial by Bolaños et al. 2025 to underline the importance of embra