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In preclinical studies, p53 loss of function impacts chemotherapy response, but this has not been consistently validated clinically. We trained a TP53-loss phenocopy gene expression signature from pan-cancer clinical samples in the TCGA. In vitro, the TP53-loss phenocopy signature predicted chemotherapy response across cancer types. In a clinical dataset of 3003 breast cancer samples treated with
Metastatic castration-resistant prostate cancer (mCRPC) is a lethal disease that resists therapy targeting androgen signaling, the primary driver of prostate cancer. mCRPC resists androgen receptor (AR) inhibitors by amplifying AR signaling or by evolving into therapy-resistant subtypes that do not depend on AR. Elucidation of the epigenetic underpinnings of these subtypes could provide important
This chapter reviews the growing body of epidemiological evidence linking long-term exposure to ambient air pollution with increased risk of dementia, including Alzheimer’s disease (AD) and vascular dementia (VaD). With air pollution now recognized as a potentially modifiable risk factor, the chapter explores mechanistic pathways, such as neuroinflammation and oxidative stress, through which pollu
Immunotherapy options for immune cold tumors, like prostate cancer, are limited. We show that AR downregulates MHCI expression/antigen presentation and that AR inhibition improves T-cell responses and tumor control. This suggests that treatments combining AR inhibitors and checkpoint blockade may improve tumor immune surveillance and antitumor immunity in patients.
Digitalization poses significant challenges to the EU VAT system, as it does in other areas of law. These challenges can be broadly divided into two main categories: those stemming from transformations in the economy, and those related to the legislative responses to these changes. In the VAT context, the first category includes the growing volume of transactions—particularly cross-border transact
The European Union (EU) has recently presented several new legal proposals for promoting ecodesign and product labeling. The aim is to harmonize national practices and rules in the EU, to regulate issues like product lifetime and repairability in a more comprehensive way, to introduce new tools like digital product passports, and to introduce labeling schemes for repairability and durability. In p
Housing is crucial for people to flourish, as it is more than shelter and physical infrastructure. The conversation discusses trajectories and ‘variegations’ in universal, decommodified, non-profit housing provision in Scandinavian countries, focusing on Sweden (allmännyttan) and Denmark (almen). It explores how Sweden’s municipal rental housing was transformed by neoliberal market fundamentalism,
Background: Interventions in the form of animal-assisted and nature-based activities are promising for young adults with autism, but there is a knowledge gap concerning the long-term values of these. Aim: The aim was to describe the activity levels in daily life and socioeconomic aspects for young adults with autism one year after a 12-week intervention with animal-assisted and nature-based activi
The fall of 2022, with the election success of a coalition of right wing and ethnoracist parties, marks the transition from a racialized to a racist state in Sweden. We analyse the discourses of three welfare projects in Swedish racial capitalism - Keynesian, Neoliberal, and ethnoracist - in relation to safety/security.Methodologically, we use CDA analysing elite institutional texts (party documen
Background: Proton beam therapy (PBT) offers dosimetric advantages in pediatric radiotherapy by reducing radiation exposure to healthy tissues. However, broad implementation raises important ethical, logistical, and equity considerations, especially in settings with limited access to advanced technologies. Procedure: This position paper by the Paediatric Radiation Oncology Society (PROS) reviews t
The clinical commissioning of beams for neutron capture therapy involves the measurement and analysis of a large amount of data in various geometries and using various detectors. We have attempted methods and considerations common to the radiotherapy field, while particular care and attention is given to the specifics of the field of neutron capture therapy. This chapter provides an introduction a
To evaluate the feasibility and acceptability of a therapist-guided, mobile app-assisted behavioural treatment for children and adolescents with chronic tic disorders, compared to videoconference-delivered behaviour therapy for tics. Pilot, single-blind, two-arm randomised controlled trial (RCT). A specialist tic disorder clinic for children and adolescents in Denmark. 30 participants with Tourett
The role of education for school-aged refugee children has evolved throughout history, influenced by time, geopolitical contexts, public perceptions, and ideas about the purposes of education. This article examines refugee education in Finland and Sweden over the past century, focusing on three periods. The first is the 1920s, when newly independent Finland agreed to the migration of large groups
The Aβ42 peptide (APP(672–713)), associated with Alzheimer disease, is highly prone to form amyloid fibrils and has been extensively studied through in vitro experiments. Such experiments represent a basis for understanding the biophysical chemistry of amyloid-related diseases. In this communication, we show that homogeneous primary nucleation in vitro of Aβ42 fibrils is a very rare event, implyin
Hard tissues in biology are typically hierarchical composites. Osteoderms are mineralized dermal structures, widespread in lizards, in which a hyper-mineralized superficial layer, the capping tissue, has recently attracted attention for its unusual structural and mechanical features, with, e.g., moduli reaching those of enamel. Here, a comparative study of osteoderms from six lizard species whose
Ecological network approaches have advanced our understanding of how species interactions influence community and evolutionary dynamics. However, a key limitation is that most network analyses rely solely on visitation data, often overlooking functional aspects of interactions. Here, we combined quantitative (visitation frequency) and qualitative (pollen removal and deposition) components to asses
In this chapter, I describe how technological progress triggers and shapes structural change within the economy and society, which in turn—if the resulting changes are significant enough—may shift the scope and outcome of established legislation and regulatory frameworks. The argument presented focuses on the ongoing digitalization, using its common technological characteristics to identify and de
The second Weiglhofer Symposium on Electromagnetic Theory concluded with a round table discussion on “Future Developments.” The panel featured Ibrahim Abdulhalim from the ECE School at Ben Gurion University, Gérard Gouesbet from the Institut National des Sciences Appliquées de Rouen, Gerhard Kristensson from Lund University, Guy Vandenbosch from Katholieke Universiteit Leuven, and Theo Rasing from
Colon capsule endoscopy is a noninvasive imaging technology primarily designed to provide detailed visualization of the colon. While the main intention of this technology is to examine the large intestine, it also captures images from the oral cavity through the small intestine as the capsule travels along the gastrointestinal tract. This chapter outlines the anatomical regions and landmarks obser
