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Large skeletal muscle injuries, such as a volumetric muscle loss (VML), often result in an incomplete regeneration due to the formation of a non-contractile fibrotic scar tissue. This is, in part, due to the outbreak of an inflammatory response, which is not resolved over time, meaning that type-1 macrophages (M1, pro-inflammatory) involved in the initial stages of the process are not replaced by

Complex recombinant biomaterials that merge the self-assembling properties of different (poly)peptides provide a powerful tool for the achievement of specific structures, such as hydrogel networks, by tuning the thermodynamics and kinetics of the system through a tailored molecular design. In this work, elastin-like (EL) and silk-like (SL) polypeptides are combined to obtain a silk-elastin-like re

One of the main challenges in regenerative medicine is the spatiotemporal control of angiogenesis, which is key for the successful repair of many tissues, and determines the proper integration of the implant through the generation of a functional vascular network. To this end, we have designed a three-dimensional (3D) model consisting of a coaxial binary elastin-like recombinamer (ELR) tubular con

Hindlimb ischemia is an unmet medical need, especially for those patients unable to undergo vascular surgery. Cellular therapy, mainly through mesenchymal stromal cell (MSC) administration, may be a potentially attractive approach in this setting. In the current work, we aimed to assess the potential of the combination of MSCs with a proangiogenic elastin-like recombinamer (ELR)-based hydrogel in

Large bone defects are a significant health problem today with various origins, including extensive trauma, tumours, or congenital musculoskeletal disorders. Tissue engineering, and in particular bone tissue engineering, aims to respond to this demand. As such, we propose a specific model based on Elastin-Like Recombinamers-based click-chemistry hydrogels given their high biocompatibility and thei

Ti-6Al-4V alloy obtained by powder metallurgy (PM) is a good candidate biomaterial in the manufacture of dental implants but its inherent porosity makes it have worse corrosion behavior than conventionally obtained alloys. In order to improve the corrosion and biological properties, surface modification technologies could be used. The plasma electrolytic oxidation (PEO) process is a novelty proces

This article examines how the principle of ‘the best interests of the child’, as enshrined in the Convention on the Rights of the Child (CRC), is interpreted, constructed, and applied in court cases involving child custody disputes. These disputes provide a globally relevant example of the CRC’s social dynamics, as they often involve interactions and negotiations among diverse professional groups.

Technology has now globally gained a prominent place in national economic policymaking. Innovation is something to protect; access to technologies such as high-end chips is something to contest. For the West, discussion of national control over technology represents a departure from the globalization era’s understanding of trade, complementarity, and mutual prosperity.In Asia’s high-growth economi

RegVis är en plattform som visualiserar nyckelvariabler inom regional utveckling och hur dessa förändras över tid och rum och hur de påverkar varandra. Genom kartor och grafer visualiseras sju variabler. Du kan välja att få en översiktlig bild av respektive variabel, eller fördjupa dig och jämföra variabler, geografiska områden etc med varandra.RegVis is a platform that visualizes key variables in regional development and how they change over time and space, as well as how they influence one another. Through maps and graphs, seven variables are displayed. You can choose to get an overview of each variable, or delve deeper and compare variables, geographic areas, etc. with one another.

Lignocellulosic biomass is an abundant, renewable and low-cost feedstock that plays a key role in the urgent transition from fossil-based resources to renewable and bio-based alternatives used within the chemical industry. Lignin, an aromatic heteropolymer, represents a significant fraction of lignocellulosic biomass, yet it is mainly considered a waste product. Over 50 million tons of Kraft ligni

The pT-differential production cross sections of non-prompt D0, D+, and Ds+ mesons originating from beauty-hadron decays are measured in proton–proton collisions at a centre-of-mass energy s = 13 TeV. The measurements are performed at midrapidity, |y| < 0.5, with the data sample collected by ALICE from 2016 to 2018. The results are in agreement with predictions from several perturbative QCD calcul

Aim: Our primary aim was to assess how dispersal limitation affected forest changes in the Northern Hemisphere during the last glacial cycle, and especially after the last deglaciation. Location: Northern Hemisphere (between 20°N and 80°N). Time Period: 50,000–0 years before present. Major Taxa Studied: Angiosperms and gymnosperms. Methods: We used the LPJ-GM 2.0 dynamic global vegetation model to

Recent estimates point to dramatic increases in private capital flowing to biodiversity. Examining main sources of this increase — equity investments and debt — this review asks how biodiversity finance is being calculated, and whether private capital flowing to biodiversity action is growing as much as reported. Furthermore, by examining the literature on the standards and metrics, we ask whether

Pollinators are estimated to benefit the reproduction of three-quarters of global leading crop species and contribute to 3%–8% of the total global food production. Ongoing declines in pollinator populations have raised concerns about repercussions for food security. Thus, there is a need to better understand how agricultural yields depend on pollinator abundance. Here, we established yield–pollina

While the future and temporality have received increased attention in economic geography in recent years, there is a need for further understanding of how this creates opportunities and challenges for our methods. Based on our independent research on environmental markets, this paper discusses the methodological challenge of studying markets-in-the-making while taking the force of the future serio

Financial capital is currently being heralded for its potential to provide social and environmental transformations. This paper provides an in-depth case study of the Seychelles Blue Bond, highlighting the state’s (fiscal and planning) capacities as central in mediating the future rents and value production when channelling thematic bond proceeds. Even as the Blue Bonds tapped into private capital

Approaches to financing biodiversity conservation tend to focus on funding gaps, but fail to address underlying political and economic drivers. We propose two strategies — tax reform and debt justice — to supercharge public financing for biodiversity and deflate harmful financial flows, while chipping away at the causes of state austerity.

With the emergence of the so-called Blue Economy, various conservation finance mechanisms and financial structures are being proposed as a means of simultaneously securing marine biodiversity and profit-making. A novel approach that is being applied within this new conservation finance frontier is the integration of ecosystem-based adaptation and insurance. By synthesizing recent literatures in po

The notion of blended finance has increasingly gained traction within development policy as a way to fill a series of “financing gaps” related to the Sustainable Development Goals. Recently, blended finance has received increased attention as a way to create biodiversity markets and attract private capital. Building on qualitative research on efforts to create markets for private investments in ma