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In the active exploration of novel biobased semicrystalline polyesters to replace petrochemical plastics, AB-type aromatic condensation polymerizations are relatively rarely investigated but gain growing attention due to the straightforward synthesis of AB-type monomers from diverse asymmetric biobased feedstocks. However, achieving high molecular weights through AB-type melt polycondensations is

The primary regulator of testicular function is the gonadotropin-releasing hormone (GnRH). This hormone is secreted in a pulsatile manner by hypothalamic neurons. GnRH stimulates the synthesis and secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary gland. LH stimulates the synthesis of testosterone (T) after binding to specific receptors on Leyd

Ulvan is a polysaccharide most abundant in green macroalgae biomass. Investigation of ulvan confirmed the potential of the polysaccharide for food, pharmaceutical and chemistry applications, emphasising the beneficial properties of ulvan oligosaccharides. Efficient production of oligosaccharides requires action of ulvan lyases capable of ensuring polysaccharide enzymatic depolymerisation. The a

In renal cell carcinoma (RCC), a majority of the patients are today diagnosed incidentally due to the frequent use of cross-sectional imaging. This has resulted in the diagnosis of smaller tumours and less advanced tumour stages. Imaging for renal tumour diagnostics and staging aim to differentiate between benign and malignant disease and precise determination of primary tumour extent before decis

The androgen receptor (AR) is central in prostate tissue identity and differentiation, and controls normal growth-suppressive, prostate-specific gene expression. It also drives prostate tumorigenesis when hijacked for oncogenic transcription. The execution of growth-suppressive AR transcriptional programs in prostate cancer (PCa) and the potential for reactivation remain unclear. Here, we use a ge

In preclinical studies, p53 loss of function impacts chemotherapy response, but this has not been consistently validated clinically. We trained a TP53-loss phenocopy gene expression signature from pan-cancer clinical samples in the TCGA. In vitro, the TP53-loss phenocopy signature predicted chemotherapy response across cancer types. In a clinical dataset of 3003 breast cancer samples treated with

Metastatic castration-resistant prostate cancer (mCRPC) is a lethal disease that resists therapy targeting androgen signaling, the primary driver of prostate cancer. mCRPC resists androgen receptor (AR) inhibitors by amplifying AR signaling or by evolving into therapy-resistant subtypes that do not depend on AR. Elucidation of the epigenetic underpinnings of these subtypes could provide important

This chapter reviews the growing body of epidemiological evidence linking long-term exposure to ambient air pollution with increased risk of dementia, including Alzheimer’s disease (AD) and vascular dementia (VaD). With air pollution now recognized as a potentially modifiable risk factor, the chapter explores mechanistic pathways, such as neuroinflammation and oxidative stress, through which pollu

Immunotherapy options for immune cold tumors, like prostate cancer, are limited. We show that AR downregulates MHCI expression/antigen presentation and that AR inhibition improves T-cell responses and tumor control. This suggests that treatments combining AR inhibitors and checkpoint blockade may improve tumor immune surveillance and antitumor immunity in patients.

Digitalization poses significant challenges to the EU VAT system, as it does in other areas of law. These challenges can be broadly divided into two main categories: those stemming from transformations in the economy, and those related to the legislative responses to these changes. In the VAT context, the first category includes the growing volume of transactions—particularly cross-border transact

The European Union (EU) has recently presented several new legal proposals for promoting ecodesign and product labeling. The aim is to harmonize national practices and rules in the EU, to regulate issues like product lifetime and repairability in a more comprehensive way, to introduce new tools like digital product passports, and to introduce labeling schemes for repairability and durability. In p

Housing is crucial for people to flourish, as it is more than shelter and physical infrastructure. The conversation discusses trajectories and ‘variegations’ in universal, decommodified, non-profit housing provision in Scandinavian countries, focusing on Sweden (allmännyttan) and Denmark (almen). It explores how Sweden’s municipal rental housing was transformed by neoliberal market fundamentalism,

Background: Interventions in the form of animal-assisted and nature-based activities are promising for young adults with autism, but there is a knowledge gap concerning the long-term values of these. Aim: The aim was to describe the activity levels in daily life and socioeconomic aspects for young adults with autism one year after a 12-week intervention with animal-assisted and nature-based activi

The fall of 2022, with the election success of a coalition of right wing and ethnoracist parties, marks the transition from a racialized to a racist state in Sweden. We analyse the discourses of three welfare projects in Swedish racial capitalism - Keynesian, Neoliberal, and ethnoracist - in relation to safety/security.Methodologically, we use CDA analysing elite institutional texts (party documen

Background: Proton beam therapy (PBT) offers dosimetric advantages in pediatric radiotherapy by reducing radiation exposure to healthy tissues. However, broad implementation raises important ethical, logistical, and equity considerations, especially in settings with limited access to advanced technologies. Procedure: This position paper by the Paediatric Radiation Oncology Society (PROS) reviews t

The clinical commissioning of beams for neutron capture therapy involves the measurement and analysis of a large amount of data in various geometries and using various detectors. We have attempted methods and considerations common to the radiotherapy field, while particular care and attention is given to the specifics of the field of neutron capture therapy. This chapter provides an introduction a

To evaluate the feasibility and acceptability of a therapist-guided, mobile app-assisted behavioural treatment for children and adolescents with chronic tic disorders, compared to videoconference-delivered behaviour therapy for tics. Pilot, single-blind, two-arm randomised controlled trial (RCT). A specialist tic disorder clinic for children and adolescents in Denmark. 30 participants with Tourett

The role of education for school-aged refugee children has evolved throughout history, influenced by time, geopolitical contexts, public perceptions, and ideas about the purposes of education. This article examines refugee education in Finland and Sweden over the past century, focusing on three periods. The first is the 1920s, when newly independent Finland agreed to the migration of large groups