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Technologies to develop and evolve the function of proteins and, in particular, antibodies have developed rapidly since the introduction of phage display. Importantly, it has become possible to identify molecules with binding properties that cannot be found by other means. A range of different approaches to create general libraries that are useful for the selection of such molecules specific for e

In numerous social control settings, staff routinely write case histories on clients to assist colleagues and authorities in treatment decisions. In this article, we examine how such institutional writing constructs ‘working versions’ of youngsters, portraying their objects of care as personally troublesome. Simultaneously, the institution is portrayed as facelessly, uniformly and collectively rem

In the present study, we evaluated the cholesterol-lowering effects of different oat bran (OB) preparations, differing regarding their peak molecular weight (MWp) of beta-glucans (2348, 1311, 241, 56, 21 or < 10 kDa), in C57BL/6NCrl mice. The diets were designed to be atherogenic (0.8 % cholesterol and 0.1 % cholic acid), and they reflected the Western diet pattern (41 % energy fat). All OB prepar

Extracellular histones released during cell damage have the capacity to cause tissue injury associated with increased leukocyte accumulation. However, the molecular mechanisms regulating histone-induced leukocyte recruitment remain elusive. The objective of this study was to examine the role of adhesion molecules in histone-dependent leukocyte accumulation by use of intravital microscopy of the mo

Changes in climate and land use, caused by socio-economic changes, greenhouse gas emissions, agricultural policies and other factors, are known to affect both natural and managed ecosystems, and will likely impact on the European terrestrial carbon balance during the coming decades. This study presents a comprehensive European Union wide (EU15 plus Norway and Switzerland, EU*) assessment of potent

BACKGROUND: Several instruments have been developed for measuring asthma control, but there is still a need to provide a structure for primary care asthma reviews. AIMS: The Active Life with Asthma (ALMA) tool was developed with the aim of structuring patient visits and assessing asthma treatment in primary care. The ability of ALMA to map out the care of asthma patients was evaluated and validate

Proxy data with large spatial coverage spanning to the preindustrial era not only provide invaluable material to investigate hydroclimate changes in different regions but also enable studies on temporal changes in the teleconnections between these regions. Applying the singular value decomposition (SVD) method to tree-ring-based field reconstructions of the Palmer drought severity index (PDSI) ove

Background An increased frequency of occupational contact hand dermatitis among surgical operating theatre personnel has been noticed. Objectives To evaluate patients with occupational contact dermatitis caused by their rubber gloves, and to describe a method for analysing the content of the allergens in the gloves. Materials and methods Patch tests were performed with the baseline series, a rubbe

BACKGROUND: To evaluate resource utilization and direct economic costs of care for patients treated with negative-pressure wound therapy (NPWT), using the Vacuum-Assisted Closure (V.A.C.) system, compared to standard moist wound therapy (MWT). METHODS: A total of 162 diabetic patients with post-amputation wounds (up to the trans-metatarsal level) entered a 16-week, randomized clinical trial. Patie

Orthostatic hypotension (OH) is associated with increased total mortality but contribution of specific death causes has not been thoroughly explored. In this prospective study, authors followed up 32,068 individuals without baseline history of cancer or cardiovascular disease (69% men; mean age, 46 years; range, 26-61 years) over a period of 24 years. Hazard ratios (HRs) for total and cause-specif

AIMS:: Tissue-specific circulating microRNAs are released into the blood after organ injury. In an ischemic porcine cardiogenic shock model we investigated the release pattern of cardiacspecific miR-208b and liver-specific miR-122 and assessed the effect of therapeutic hypothermia on their respective plasma levels. METHODS AND RESULTS:: Pigs were anesthetized and cardiogenic shock was induced by i

In cases with total ankle replacement (TAR) failure, a decision between revision TAR and salvage arthrodesis (SA) must be made. In a previous study, we analyzed revision TAR and found low functional outcome and satisfaction. The aims of the current study were to analyze SA concerning failure rate and patient-related outcome measures (PROMs).

Background: Central venous oxygen saturation (ScvO(2) ) is suggested to reflect the adequacy of oxygen delivery, and the main objective of the present study was to determine whether ScvO(2) is associated with outcome in haemodynamically stabilized trauma patients. Methods: Haemodynamically unstable trauma patients receiving a central venous line within 1 h of admission were eligible for inclusion