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The laboratory mouse Mus musculus has long been used as a model organism to test hypotheses and treatments related to understanding the mechanisms of disease in humans; however, for these experiments to be relevant, it is important to know the complex ways in which mice are similar to humans and, crucially, the ways in which they differ. In this chapter, an in-depth analysis of these similarities
Background: Studies on the incidence of Cushing’s disease (CD) are few and usually limited by a small number of patients. The aim of this study was to assess the annual incidence in a nationwide cohort of patients with presumed CD in Sweden. Methods: Patients registered with a diagnostic code for Cushing’s syndrome (CS) or CD, between 1987 and 2013 were identified in the Swedish National Patient R
Purpose: Fluoropyrimidine plus platinum (FP) is currently the standard treatment for esophageal cancer (EC). In recent years, taxane-based chemotherapy has also been used and has shown good efficacy in EC. This study aims to investigate the advantages of taxane-based over FP chemotherapy, as well as discuss its drawbacks, in the treatment of EC. Patients and methods: A literature search was done f
This European Randomized study of Screening for Prostate Cancer trial follow-up reports that repeated screening reduces the risk of dying from prostate cancer for up to 16 yr.
Seagrass ecosystems provide an array of ecosystem services ranging from habitat provision to erosion control. From a climate change and eutrophication mitigation perspective, the ecosystem services include burial and storage of carbon and nutrients in the sediments. Eelgrass (Zostera marina) is the most abundant seagrass species along the Danish coasts, and while its function as a carbon and nutri
Purpose: The mammalian target of rapamycin is an enzyme that regulates cell metabolism and proliferation. It is up-regulated in aggressive tumors, such as glioblastoma, leading to increased glucose uptake and consumption. It has been suggested that glucose CEST signals reflect the delivery and tumor uptake of glucose. The inhibitor rapamycin (sirolimus) has been applied as a glucose deprivation tr
In vast areas of the ocean, the scarcity of iron controls the growth and productivity of phytoplankton. Although most dissolved iron in the marine environment is complexed with organic molecules, picomolar amounts of labile inorganic iron species (labile iron) are maintained within the euphotic zone and serve as an important source of iron for eukaryotic phytoplankton and particularly for diatoms.
It has been hypothesized that highly productive coastal ecosystems, such as seagrass meadows, could lead to the establishment of ocean acidification (OA) refugia, or areas of elevated pH and aragonite saturation state (Ωa) compared to source seawater. However, seagrass ecosystems experience extreme variability in carbonate chemistry across short temporal and small spatial scales, which could impac
There is a growing recognition for the need to understand how seawater carbonate chemistry over coral reef environments will change in a high-CO2 world to better assess the impacts of ocean acidification on these valuable ecosystems. Coral reefs modify overlying water column chemistry through biogeochemical processes such as net community organic carbon production (NCP) and calcification (NCC). Ho
MXCuBE2 is the second-generation evolution of the MXCuBE beamline control software, initially developed and used at ESRF – the European Synchrotron. MXCuBE2 extends, in an intuitive graphical user interface (GUI), the functionalities and data collection methods available to users while keeping all previously available features and allowing for the straightforward incorporation of ongoing and futur
This paper examines usage, function and meaning of the Swedish concept of ”otrygghet” (approx.: unsafety or insecurity) in political documents from two periods: 1970s and 2010s. Departing from a theoretical framework inspired by conceptual historian Reinhart Koselleck, this paper synchronically compares documents from Sweden’s two largest parties (Socialdemokraterna and Moderaterna), and diachroni
The brilliance and the sufferings of the literary critique in its first instance cannot be separated from the brilliance and suffering of the critic who firstly assesses the work. The question is whether the literary reviewer has become responsible only with public relations and the promotion of the book; more of a blurb generator - which means simple incandescent signaling - than analyzer.
In this article, we propose that three types of focus constructions in Japanese-clefts, in-situ focus, and sluicing/stripping-share the same underlying structure and are derived by syntactic "metamorphosis" from one structure to another. After revealing similarities between cleft constructions and in-situ focus constructions, we specifically propose that the latter underlies the former, which is d
This paper revisits empirical and theoretical problems of focus prosody in Japanese, and proposes a new analysis. Contrary to the widely accepted assumption that focus directly or indirectly modifies prosodic phrasing, various studies have shown that prosodic boundaries remain unchanged when a focus is added to a sentence. It is proposed that phonetic effects of focus (F0-rise on the focused word,
Caroline Féry and Shinichiro Ishihara proposes a model of how syntax and information structure (focus and givenness) shape prosody where prosodic phrasing and tonal effects are kept apart. It is argued that the prosodic effects of syntactic structure and those of information structure should be kept apart. It is shown that in German and Japanese, syntactic structure primarily influences prosodic p
This paper investigates the question of whether and how Second Occurrence Focus (SOF) is realized phonetically in German. The apparent lack of phonetic marking on SOF has raised much discussion on the semantic theory of focus (Partee 1999, Rooth 1992). Some researchers have reported the existence of phonetic marking of SOF in the postnuclear area (Rooth 1996, Beaver et al. 2007). In our experiment
