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Large international biobank studies can make substantial contributions to scientific research by validation of the biological importance of previous research and by identification of previously unknown causes of disease. However, regulations for patient consent that are too strict and discrepancies in national policies on informed consent might hinder progress. Therefore, establishment of common g
Associations between A Quick Test of Cognitive Speed (AQT) perceptual and cognitive speed and neuropsychological tests, including the Wechsler Adult Intelligence Scale-Third Edition (WAIS-III), Mini Mental State Examination (MMSE), and the Trail Making Test (TMT), were evaluated in 41 neuropsychiatric patients. Neuropsychological and neurological tests, including CT scan, were administered to all
A quantitative validation of the microdialysis ethanol technique was performed in cat gastrocnemius muscle. Six to eight microdialysis probes were inserted into the isolated muscle preparation and perfused (0.5-10.0 microliters/min) with Krebs-Henseleit buffer containing between 5 and 1,000 mmol/l ethanol. Skeletal muscle blood flow was held constant in the range of 4-99 ml.100 g-1.min-1 by a serv
The main function of the reactor containment, i.e. to ensure tightness at a major internal accident, depends directly on the prestressing system. To secure that the prestress level is sufficient, the tendon force has been measured during the whole time of operation. The general results from these measurements show that the loss of prestress 30 years after tensioning is between 5 and 10%. This is m
The Grossman model has been extended recently in order to take account of the fact that most people lead their lives in a family--using frameworks in which family members, respectively, (a) have common preferences and (b) are Nash-bargainers. These models, however, do not consider individual incentives for behaving strategically. In the model presented in this paper, spouses interact strategically
Background: The EVIDENCE (Evidence of Interferon Dose-Response: European North American Comparative Efficacy) Study demonstrated that patients with multiple sclerosis (MS) who initiate interferon beta-la therapy with 44 μ g 3 times weekly (TIW) were less likely to have a relapse or activity on magnetic resonance imaging (MRI) compared with those who initiate therapy at a dosage of 30 μ g 1 time we
The production of deuterons and antideuterons in the transverse momentum range 1.1 < p(T)< 4.3 GeV/c at midrapidity in Au+Au collisions at root s(NN) = 200 GeV has been studied by the PHENIX experiment at RHIC. A coalescence analysis, comparing the deuteron and antideuteron spectra with that of proton and antiproton, has been performed. The coalescence probability is equal for both deuterons and a
We report on an approach for sulfur dioxide monitoring using broadband absorption spectroscopy in the ultraviolet spectral range. The method was applied in real-time measurements and has the advantage of straightforward data evaluation, limited susceptibility for interference from other gases, and low degree of complexity compared with other real-time optical detection techniques having the same p
Apomorphine is a potent, nonselective, direct-acting dopamine-receptor agonist. Given subcutaneously, it has a rapid onset of antiparkinsonian action qualitatively comparable to that of levodopa. Despite its long history, it was not until peripheral dopaminergic side effects could be controlled by oral domperidone that the clinical usefulness of apomorphine in Parkinson's disease began to be inves
Using literature data on the gas phase reaction between free lanthanide atoms and carbon dioxide, we have found an isokinetic relation for seven of the twelve investigated elements with an isokinetic temperature, T-iso of 2500 +/- 330 K. This value is analyzed in the framework of the model of selective energy transfer, SET, indicating that metal-CO2 complexes are formed as pre-reaction states. The
Despite a high prevalence of persistent groin pain after hernia repair, the specific nature of the pain and its clinical manifestation are poorly known. The aim of this study was to determine the type of post-herniorrhaphy pain and its influence on daily life. In order to assess long-term pain qualitatively and to explore how it affects quality of life, 100 individuals with persisting pain, identi
The PHENIX experiment has measured midrapidity transverse momentum spectra (0.4
We have examined the importance of the actin-based molecular motor myosin 5a for insulin granule transport and insulin secretion. Expression of myosin 5a was downregulated in clonal INS-1E cells using RNAinterference. Stimulated hormone secretion was reduced by 46% and single-cell exocytosis, measured by capacitance recordings, was inhibited by 42% after silencing. Silencing of Slac-2c/MYRIP, whic
Background Long-chain polyunsaturated fatty acid (LCPUFA) especially the n-3-FA of skeletal muscle phospholipids may facilitate insulin action, whereas saturated and trans-FA act oppositely. Community studies show that non-diabetic weight matched obese men and women display similar insulin resistance, despite the fact that an android fat distribution is detrimental to insulin action. The increased
We have exploited the spatial and kinetic resolution of ellipsometry to monitor the lateral movement of inhomogeneous patches of material in mixed adsorption layers of poly(ethylene imine) and sodium dodecyl sulfate at the air/liquid interface. We show that the choice of sample preparation methods can have a profound effect on the state of the interface for chemically equivalent samples. The exten
Delayed contrast-enhanced MRI of cartilage (dGEMRIC) is a noninvasive technique to study cartilage glycosaminoglycan (GAG) content in vivo. This study evaluates dGEMRIC in patients with preradiographic degenerative cartilage changes. Seventeen knees in 15 patients (age 35-70) with arthroscopically verified cartilage changes (softening and fibrillations) in the medial or lateral femoral compartment
