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Complement factor C3 is one of the most abundant proteins in the bloodstream and a central part of the complement system. Upon activation, C3 facilitates bacterial recognition and clearance in the extracellular environment. Initially regarded as a serum effector component, C3 is also emerging as an intracellular protein regulating basic cellular processes. Previously, we reported that intracellula
Kin recognition, the ability to identify genetic relatives, relies on familiarisation for the creation of recognition templates. During development, parent and embryo(s) are exposed to chemical, auditory, and tactile cues that can communicate reliable genetic information. We discuss how these cues can have organisational effects during a time of heightened phenotypic sensitivity, creating postnata
Purpose: Boys with genetic syndromes have an increased risk of undescended testes (UDT), but laparoscopic findings and outcomes after two-stage Fowler-Stephens orchiopexy (FS2) are rarely reported. This study aims to compare laparoscopic findings and results after FS2 between syndromic and non-syndromic boys. Methods: A retrospective cohort study on boys with UDT who underwent laparoscopy between
Sensor degradation poses a significant challenge in autonomous driving. During heavy rainfall, interference from raindrops can adversely affect the quality of LiDAR point clouds, resulting in, for instance, inaccurate point measurements. This, in turn, can potentially lead to safety concerns if autonomous driving systems are not weather-aware, i.e., if they are unable to discern such changes. In t
An autonomous service robot should be able to interact with its environment safely and robustly without requiring human assistance. Unstructured environments are challenging for robots since the exact prediction of outcomes is not always possible. Even when the robot behaviors are well-designed, the unpredictable nature of the physical robot-object interaction may lead to failures in object manipu
Multidimensional diffusion MRI is a promising new MRI approach that has the potential to non-invasively give information about brain microstructure at an unprecedented level of detail. The present contribution briefly reviews the salient features of the novel method, its historical background and differences with conventional methods, as well as the remaining challenges that have to be overcome in
CONTEXT: People viewed as "overweight" or "obese" are vulnerable to weight-based discrimination, creating inequities and adverse health outcomes. Given the high rates of obesity recorded globally, studies documenting weight discrimination in multiple countries, and an absence of legislation to address this form of discrimination, research examining policy remedies across different countries is nee
Six coumarins were isolated from two bioactive fractions of the 70% ethanol extract from the twigs and leaves of Wikstroemia indica (L.) C.A. Mey. (Thymelaeaceae), namely the ethyl acetate fraction (WIE) and the water fraction (WIW). These compounds were identified as umbelliferone (1), daphnoretin (2), daphnorin (3), adicardin (4), wikstronutin (5), and triumbelletin-7-O-β-D-glucoside (6). Compou
Despite growing emphasis on home-based rehabilitation following stroke, there remains limited understanding of how to effectively tailor services to individual needs. This study employed concept mapping to explore diverse stakeholder perspectives on adapting home-based rehabilitation to better support the recovery process after stroke. Through this mixed-methods participatory approach, we engaged
Many real-world systems generate multivariate time series data, often exhibiting self-similarity and scale-invariance across different modalities. The estimation of Hurst exponents in such settings is crucial for analyzing long-range dependencies. Yet, traditional eigenanalysis-based methods suffer from scale-dependent distortions, particularly in the presence of scaling amplitude discrepancies. I
BACKGROUND: Fever is associated with brain injury after cardiac arrest. It is unknown whether fever management with a feedback-controlled device impacts patient-centered outcomes in cardiac arrest patients. This trial aims to investigate fever management with or without a temperature control device after out-of-hospital cardiac arrest. METHODS: The TEMP-CARE trial is part of the 2 × 2 × 2 factoria
The first measurements of proton emission accompanied by neutron emission in the electromagnetic dissociation (EMD) of Pb208 nuclei in the ALICE experiment at the Large Hadron Collider are presented. The EMD protons and neutrons emitted at very forward rapidities are detected by the proton and neutron zero degree calorimeters of the ALICE experiment. The emission cross sections of zero, one, two,
This paper introduces a novel dataset that serves as a prototype of what we call the ‘Job Ads Database’ (JADB). The underlying job advertisements are gathered from the Swedish digitalized newspaper corpus hosted by and made accessible through the Swedish National Library (Kungliga Biblioteket). JADB enables studying how the frequency and content of job advertisements change over time and sheds new
Summary Data on species' demography are essential to detect changes in population size, identify drivers of population change, motivate conservation plans, or evaluate the effectiveness of management. The Arctic Skua Stercorarius parasiticus is a seabird with a circumpolar distribution, which is listed as Endangered on the International Union for Conservation of Nature (IUCN) European Red List, al
This paper proposes an alternative semi-analytical Fourier modal method adapted for general periodic anisotropic gratings made of dielectrics with moderate to low index profiles corresponding to materials ranging from conventional dielectric 3D printing materials to ceramic materials. The proposed method is closely related to the classical rigorous coupled wave analysis built on scattering matrice
Voice problems are common among workers in occupations with high demands on oral communication. For sustaining vocal health, it is important to find efficient ways for how to reduce strain on the voice at work, and one way to do so is optimizing the room acoustics for communication. However, to date we do not know enough about what kind of room acoustic conditions that support voice and speech mos
