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Avian haemosporidian parasites are globally widespread with a broad repertoire of hosts. When infected, the host can either reduce (resistance) and/or limit the severity of parasitaemia (tolerance). Oxidative stress plays a pivotal role in the host's resistance and tolerance, as well as its detrimental endpoints. The rationale behind this paradox lies in the dual role of reactive oxygen species (R
Streaming applications are often described using dataflow actor models with a fixed network structure, allowing for static analysis and efficient hardware implementation. However, this fixed structure hinders scalability and design space exploration. This article investigates a representative dataflow toolchain, the StreamBlock compiler for the CAL actor language, along with its Actor Machine (AM)
Chronic psychological stress is increasingly recognized as a major public health concern, contributing to cardiovascular disease, obesity, asthma, and impaired bone health. Although the mechanisms linking stress to skeletal dysregulation are well characterized in adults, pediatric studies remain limited. Longitudinal and mechanistic studies are needed to clarify how stress affects bone accrual dur
Background: Human immunodeficiency virus type 1 (HIV-1) is one of the fastest-evolving human pathogens. Understanding HIV-1 transmission, within-host adaptation, and evolutionary dynamics is pivotal for development of interventions and vaccines. HIV-1 infection is generally caused by a single transmitted founder virus (TFV), and TFV sequences are typically obtained using single genome amplificatio
This paper uses a gender lens to analyse how bicycle-powered mobility futures can be articulated as counter-hegemonic alternatives to automobility. Drawing on interviews with transport professionals and activists, we interpret participants’ visions as efforts to rearticulate dominant understandings of everyday life, space, and time. Even though automobility continues to structure the horizon, we f
Objectives: To describe the rationale, design and data collection procedures of the Swedish CArdioPulmonary bioImage Study (SCAPIS) re-examination, which, in its further scope, aims to quantify and explain the development of atherosclerosis, pathological cardiovascular ageing, longitudinal decline in lung function and the malignant transformation of pulmonary nodules among middle-aged Swedes in th
This paper examines the electoral impact of economic growth through increased foreign tourism using data from Croatia. To identify causal effects, the paper applies an instrumental variable strategy, which uses variation in the ruggedness of the local terrain to estimate the network of least-cost paths. The results suggest that an increase in foreign tourism reduces nationalist voting, and increas
Enzymes are dynamic entities, and their conformational dynamics are intimately linked to their function and evolvability. In this context, protein tyrosine phosphatases (PTPs) are an excellent model system to probe the role of conformational dynamics in enzyme function and evolution. They are a genetically diverse family of enzymes, with a highly conserved catalytic domain, identical catalytic mec
Discovering topological quantum materials that combine nontrivial topology with large bandgaps and experimentally accessible signatures remains a central pursuit in condensed matter physics. We demonstrate, through first-principles calculations and tight-binding modeling, that pyrite-type osmium disulfide (OsS2) is a fragile topological insulator (FTI) characterized by an exceptionally large direc
Background: Health system performance assessment helps identify areas for improvement and guides policy initiatives. Although well-validated indicators exist for measuring organ donation and transplantation performance at the facility level, consensus on indicators for assessing national programmes is lacking. The aim of this study was to develop a comprehensive scorecard for evaluating national o
Introduction: Despite increasing recognition of pediatric acute-onset neuropsychiatric syndrome (PANS), its neuropsychological underpinnings remain limited, particularly in relation to obsessive-compulsive disorder (OCD) symptoms. PANS manifests abruptly with severe OCD and/or eating restrictions alongside concurrent neuropsychiatric symptoms, causing distress and functional impairment. This study
Fire has shaped terrestrial ecosystems for hundreds of millions of years. Human activities dramatically shift natural fire regimes, leading to adverse conservation impacts that are projected to increase in severity. Many animals appear ill-equipped to face these drastic changes, and they may be unable to adapt rapidly enough. In contrast, behavioural plasticity could offer a faster solution to ach
Second primary malignancies (SPMs) increasingly affect mantle cell lymphoma (MCL) survivors. In nationwide Danish and Swedish cohorts (2000–2020), we evaluated overall survival among MCL patients with SPMs versus matched non-lymphoma individuals with comparable malignancies and MCL patients without SPMs, respectively. Of 3094 MCL survivors, 19% in Denmark and 15% in Sweden developed an SPM, with a
Aims. We investigate the formation and evolutionary trajectory of the Milky Way’s inner and outer galactic regions using stars from open clusters in the Gaia-ESO OC survey. Methods. Using numerical simulations from Chempy, we leveraged Markov chain Monte Carlo sampling techniques to derive galactic evolutionary parameters for each open cluster by fitting measured abundances of elements C, N, O, Mg
Moult, the regular replacement of feathers, is a resource-intense avian annual-cycle stage. Resource allocation to support feather regrowth may require downregulation of other physiological processes, such as immune function, which is critical for preventing disease-related mortality. At the same time, the emergence of new feathers may increase the risk of skin injury and infection, potentially re
Objective: The aim of this study was to investigate the experiences of school nurses working with refugee children from Ukraine. Design: This research was conducted as a qualitative interview study, using an inductive approach and a semi-structured interview guide. Sample: School nurses (n = 8) from different parts of Sweden were interviewed, and the data were analyzed through a qualitative conten
Objectives The aim was to estimate the prevalence and risk of respiratory symptoms among workers exposed to epoxy resin systems in the wind turbine industry. Methods We conducted a cross-sectional study including 180 epoxy-exposed production workers from two Danish wind turbine blade factories and 41 non-exposed office workers. Respiratory symptoms were defined as having two or more symptoms (i.e.
Background: The prognostic benefit of percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) in stable coronary artery disease (CAD) remains uncertain. Objectives: To evaluate long-term survival following CTO PCI compared with medical therapy (MT) using target trial emulation and a nationwide real-world registry. Methods: We included 7813 patients with stable CAD and a document
