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Background and Objectives – Limbic-predominant age-related TDP-43 encephalopathy (LATE) is characterized by an amnestic- and limbic-predominant phenotype, which can mimic Alzheimer disease (AD). In a memory clinic cohort, we tested whether clinical criteria for LATE can detect a clinical profile of LATE that is distinct from AD.Methods – In this retrospective examination of a longitudinal memory c

Objective. To compare the reproducibility of the standing extended view (SEV) (also known as the standing anteroposterior view) with the semiflexed, postero-anterior view [the 'metatarsophalangeal' (MTP)] view for assessing joint space width (JSW) and osteophytes in osteoarthritis of the knee when used in a busy routine X-ray department. Methods. Forty-seven patients (24 men) had both SEV and MTP

Adaptive data-dependent allocation designs are used in phase III clinical trials having two or more competing treatments with sequential entrance of patients, in order to allocate a larger number of patients to the better treatment. The odds ratio is a popular concept for biomedical practitioners; hence, odds-ratio-based adaptive designs could be very useful in practice. Rosenberger et al. (2001)

Introduction – Hand-arm vibration syndrome (HAVS) is a chronic disease to vessels and nerves caused by vibrations. In Sweden, the medical check-up for vibrations (MCV) implements the EU surveillance system to detect early cases. No earlier research has shown participation in MCVs, nor why MCVs is avoided. We aimed to improve the understanding on avoidance of MCVs among vibration-exposed workers. M

This study presents an integrated simulation framework that combines agent-based transport modeling with probabilistic load-flow analysis to quantify power system loading of long-haul heavy-duty electrification. The approach is applied to a case study considering fully electrified road freight in the Skåne region in Sweden, using high-resolution transport demand data and the actual power grid mode

Introduction:Exclusive breastfeeding (EB) is globally recommended due to health benefits for women and their infants. Home-based postnatal midwifery care (HBPMC) is a model of care where midwives give in-home care during the first postnatal week. The study objectives were to investigate breastfeeding outcomes at two months after birth, in women and newborns receiving HBPMC, and to identify risk fa

A random labyrinth is a disordered environment of scatterers on a lattice. A beam of light travels through the medium, and is reflected off the scatterers. The set of illuminated vertices is studied, under the assumption that there is a positive density of points, called `normal points', at which the light behaves in the manner of a simple symmetric random walk. The ensuing `random walk in a labyr

This paper is about simple random walks on $Z^d$, $d \ge 3$, in a random field of traps, the density of which tends to zero at infinity. We distinguish between the quenched problem (when the traps are fixed) and the annealed problem (when the traps are updated each unit of time). Our goal is not only to find a criterion for zero vs. positive probability of survival, but also to show three differen

Germline mutations in BRCA1 and BRCA2 confer high risks of breast cancer. However, evidence suggests that these risks are modified by other genetic or environmental factors that cluster in families. A recent genome-wide association study has shown that common alleles at single nucleotide polymorphisms (SNPs) in FGFR2 (rs2981582), TNRC9 (rs3803662), and MAP3K1 (rs889312) are associated with increas

Background and AimsThe life expectancy of adult patients with congenital heart disease (ACHD) has improved, thus shifting the research focus towards age-related comorbidities to continue to improve patient outcomes. This study aimed to investigate all-cause mortality and recurrent acute myocardial infarction (AMI) in adults with and without congenital heart disease.MethodsA nationwide case control

The success of cell therapy for type 1 diabetes (T1D) depends on reliable differentiation of stem cells into functional pancreatic islets. Current protocols produce stem cell-derived islets (SC-islets) that contain non-endocrine cells and show limited maturity. We developed a robust protocol that generates functional SC-islets from all eight tested human pluripotent stem cell (hPSC) lines. Differe

Abstract: Before the introduction of prostate MRI, prostate cancer screening relied on prostate-specific antigen (PSA) testing followed by a systematic biopsy. Although this approach reduced prostate cancer mortality in large, randomized screening trials, its net benefit was questionable because of substantial overdiagnosis. In response, more precise screening tools have been developed. Diagnostic

Ambivalence is widely regarded as a source of ontological insecurity and anxiety due to its close association with uncertainty, undecidability, and indeterminacy. While ontological security studies (OSS) has usefully engaged with the concept of ambivalence as an epistemic phenomenon and its manifestations in international politics such as ‘strangers’, almost no attention has been paid to ambivalen

Maintaining low background levels is essential for analytical instruments, such as in supercritical fluid chromatography (SFC) coupled to high-resolution mass spectrometry (HRMS). An approximate tenfold increase of the background was observed in our laboratory when a new CO2 cylinder with a dip tube was installed on a SFCHRMS system. Most analyte peaks were obscured. This study aimed to find the c

The cardiovascular effects of coffee consumption remain debated, particularly regarding early-stage subclinical atherosclerosis. This study investigated the association between coffee intake, genetic predisposition, and the risk of subclinical coronary and carotid atherosclerosis in 24,835 participants from the Swedish CArdioPulmonary bioImage Study (SCAPIS). Coffee intake was assessed via self-re

We report on the shift of energies released during Auger cascades in rare-gas ions, when the ions are not isolated but embedded in a homogeneous cluster. By combining high-resolution electron spectroscopy with multielectron coincidence spectroscopy of small Ar and Xe clusters, we investigate the dependence of Auger electron emission energies on the charge state of the emitting ion in the polarizab

Using Swedish register data for 1993–2022, this paper documents robust spatial heterogeneityin the relationship between transfer generosity and local employment. Transfer reductions areassociated with lower employment among individuals far from the labour market in immigrant-dense neighbourhoods, but with higher employment among individuals with stronger labour-market attachment. This pattern is d

Background: Trigeminal neuralgia is sometimes referred to as the suicide disease, but long-term occurrence of comorbidities and mortality are not well known. The aim of the present study was to investigate whether patients diagnosed with trigeminal neuralgia have an increased risk of morbidity and mortality compared to the general population. Methods: A nationwide, retrospective cohort study was c

The role of genomic variants in disease has expanded significantly with the advent of advanced sequencing techniques. The rapid increase in identified genomic variants has led to many variants being classified as Variants of Uncertain Significance or as having conflicting evidence, posing challenges for their interpretation and characterization. Additionally, current methods for predicting pathoge