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BACKGROUND: Alterations in ribosomal DNA copy number (rDNA-CN) and global DNA methylation have been associated with genomic instability and various diseases. However, their relevance in myocardial infarction (MI) has not been fully investigated.METHODS: We measured rDNA-CN and global DNA methylation in blood samples from MI patients ( n = 100) and healthy controls ( n = 109) using Droplet Digital
BACKGROUND: Long COVID has emerged as a global health challenge, with increasing evidence of cardiovascular sequelae. Most previous studies have focused on hospitalised cohorts, whereas cardiovascular risk in community-managed long COVID cases remains less explored. We aimed to investigate the incidence of major cardiovascular events in individuals with long COVID compared to those without long CO
Postural orthostatic tachycardia syndrome (POTS) is associated with multiple autonomic symptoms, including gastrointestinal (GI) complaints, and has been linked to insulin resistance. We aimed to explore HbA1c, circulating metabolic hormones (insulin, C-peptide, GIP, GLP-1, glucagon, leptin, and peptide YY) and cortisol, and their associations with hemodynamic parameters and GI symptoms in POTS. T
This article explores the potential of full-count historical census microdata to enhance our understanding of occupational activity and retirement among older men and women in Sweden between 1880 and 1910 – a period preceding the introduction of a universal pension system. Drawing on the SwedPop infrastructure, we examine how occupational information was recorded, coded, and interpreted in the Swe
BACKGROUND: The aim was to improve the realism of patient models for Monte-Carlo based evaluation of image-based quantification of tumour volume and activity in [68Ga]Ga-DOTA-TOC PET and [177Lu]Lu-DOTA-TATE SPECT images.METHODS: Three phantoms from the XCAT population were used as basis. Tumour structures were obtained from segmentation of patient 68Ga-PET images and positioned at relevant positio
This thesis explores the potential of vernacular architecture in contemporary design through the proposal of a community centre for Kitini Secondary School in Godawari, Nepal. The project is grounded in a site-specific, research-led design methodology, informed by fieldwork, material studies, and community engagement. It explores how traditional Nepali building practices, particularly the use of l
