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Research continues to identify genetic variation, environmental exposures, and their mixtures underlying different diseases and conditions. There is a need for screening methods to understand the molecular outcomes of such factors. Here, we investigate a highly efficient and multiplexable, fractional factorial experimental design (FFED) to study six environmental factors (lead, valproic acid, bisp

Background: Temperament and character have been shown to be important factors in understanding psychiatric and neurodevelopmental disorder. Adults with autism spectrum disorder (ASD) have repeatedly been shown to have a distinct temperament and character, but this has not been evaluated in relation to psychiatric comorbidity and ASD diagnostic stability. Aims: To examine temperament and character

OBJECTIVE: To study the effect of methotrexate on male fertility and subsequent effects on their children, for which data are scarce and contradictory.DESIGN: Nationwide multiregister cohort study.SETTING: Not applicable.SUBJECT(S): All children born alive in Sweden between 2006 and 2014 and their fathers. Three cohorts were defined: children to fathers with periconceptional methotrexate exposure

BackgroundUniversity students experience a distinct working environment in the context of completing their studies. In line with existing research into the connection between workplace environment and stress, it is rational to believe that such study environments can affect the level of stress that students experience. However, few instruments have been developed for measuring this.ObjectiveThe ai

The food industry is actively adopting carbon neutral strategies aligned with the principles of Industry 4.0 to establish long-term goals for reducing carbon emissions and accelerating the transition to a low-carbon food production industry. Industry 4.0, often referred to as the fourth industrial revolution, emphasizes the integration of digital technologies, automation, and data exchange into ma

Growing evidence suggests that young migrants are particularly vulnerable to sexual violence. As young migrants often lack family and social networks, professionals are often the recipients of disclosures of sexual violence. This study aimed to explore how professionals experience young migrants’ disclosures of sexual violence. A qualitative design was used, based on 14 semi-structured interviews

Background: A diagnosis of prostate cancer (PC) may cause psychosocial distress that worsens quality of life; however, long-term mental health outcomes are unclear. Objective: To determine the long-term risks of major depression and death by suicide in a large population-based cohort. Design, setting, and participants: This was a national cohort study of 180 189 men diagnosed with PC during 1998–2

Background: Global health and sustainable development have increasingly been recognised as important parts of medical education, yet education on these issues remains fragmented and scarce. In 2020, a bill to reform the national medical curricula across all Swedish medical schools was introduced, including a greater emphasis on global health and sustainable development. This study aimed to explore

PURPOSE: Available evidence indicates that dipyridamole enhances the anti-thrombotic effects of aspirin for the prevention of secondary strokes. Aspirin is a well-known non-steroid anti-inflammatory drug. This anti-inflammatory property has turned aspirin into a potential drug for inflammation-related cancers such as colorectal cancer (CRC). Here, we aimed to explore whether the anti-cancer effect

Several alkaline earth or rare earth binary monosilicides and -germanides possess complex bonding properties, such as polycation formation exceeding the scope of classical electron counting rules. In this study, we present characterization by powder and single-crystal diffraction and thermal analysis of CeGe, one of the few monogermanides crystallizing in the FeB-type structure. Comparative comput

A Josephson diode is a nonreciprocal circuit element that supports a larger dissipationless supercurrent in one direction than in the other. In this Letter, we propose a class of Josephson diodes based on supercurrent interferometers composed of Andreev bound state Josephson junctions or interacting quantum dot Josephson junctions, which are not diodes themselves but possess nonsinusoidal current-

Deciphering the genetic basis of prostate-specific antigen (PSA) levels may improve their utility to screen for prostate cancer (PCa). We thus conducted a transcriptome-wide association study (TWAS) of PSA levels using genome-wide summary statistics from 95,768 PCa-free men, the MetaXcan framework, and gene prediction models trained in Genotype-Tissue Expression (GTEx) project data. Tissue-specifi

Prostate-specific antigen (PSA) screening for prostate cancer remains controversial because it increases overdiagnosis and overtreatment of clinically insignificant tumors. Accounting for genetic determinants of constitutive, non-cancer-related PSA variation has potential to improve screening utility. In this study, we discovered 128 genome-wide significant associations (P < 5 × 10 -8) in a multi-

Financial security influences good quality housing, health, and longevity, but few recent studies of the financial aspects of aging in place have been published. We explored strategies used to age in place and thoughts about future housing among women aged 65 and older living with a low pension in Sweden. We conducted semi-structured qualitative interviews with 13 women aged 65 and older with a lo