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First-Degree AV Block-An Entirely Benign Finding or a Potentially Curable Cause of Cardiac Disease?

First-degree atrioventricular (AV) block is a delay within the AV conduction system and is defined as a prolongation of the PR interval beyond the upper limit of what is considered normal (generally 0.20 s). Up until recently, first-degree AV block was considered an entirely benign condition. In fact, some complain that it is a misnomer since there is only delay and no actual block in the AV condu

Assessing reporting obligations under TRIPS Article 66.2

The reporting obligations under the TRIPS Agreement should provide a basis for discovering how the developed countries provide incentives to enterprises and institutions in their territories for the purpose of promoting and encouraging technology transfer and if these activities lead to concrete and helpful best industry practices. The obligations must be seen in their context. Other international

Discovery of targets for tumor immunotherapy using phage display technology

This thesis has focused on the development of methods and their applications for the identification of antibodies reactive with tumor associated antigens (TAA). The phage display technology provides a powerful mean to generate antibodies potentially useful for tumor immunotherapy. A phage antibody displays on its surface an antibody fragment encoded by a gene inserted in the phage genome. The phag

Development of Protein Microarray Chip Technology: An Outlook towards Proteomics and Diagnostics

One attractive method for monitoring biomolecular interactions in a highly parallel fashion is the use of microarrays. Microarrays can be applied for screening proteins which makes it an attractive tool in clinical diagnostics, drug discovery studies and basic protein research; even though many methodological challenges and ones relating to the quality control of microarrays still need to be solve