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Understanding the role of redox modifications during mitochondrial signaling

Mitochondria are most known as producers of ATP and for their metabolic functions in eukaryotic cells. However, these are not the only roles of these organelles, as they also have the means to communicate with the nucleus. These signals going from mitochondria to the cell nucleus are termed mitochondrial retrograde signaling or regulation (MRR). In Arabidopsis thaliana, the master regulator of MRR

Increased mitochondrial fusion via systemic OPA1 overexpression promotes dyslipidemia and atherosclerosis in LDLR deficient mice

Objective: Mitochondria are involved in cellular metabolism, energy production, calcium homeostasis, and the synthesis of sterols and bile acids (BAs). Emerging evidence suggests that mitochondrial dynamics including biogenesis, fusion, fission, and mitophagy critically influence cardiometabolic diseases, yet their role in atherogenesis remain poorly understood. Mitochondrial fusion ensures metabo

Renal microthrombosis and thrombomodulin deficiency in COVID-19–associated acute kidney injury

Background: Severe COVID-19 frequently involves multi-organ dysfunction, including acute kidney injury (AKI), which affects up to 85% of critically ill patients. While both direct viral infection and systemic effects are implicated, the role of renal microthrombosis remains poorly defined in COVID-19 and AKI. Angiopoietin-2, a pro-inflammatory cytokine, and cleaved thrombomodulin is elevated in pl

Haunted Histories of Experimental Psychology : A Re-Examination of Hodgson and Davey’s Mal-Observation Report

In 1887, psychical researchers Richard Hodgson and S. J. Davey published a study that revealed counterintuitive aspects of human cognition: How healthy, sober, honest observers of events can be prone to seemingly remarkable errors of eyewitness testimony. Their report, titled ‘The Possibilities of Mal-Observation and Lapse of Memory from a Practical Point of View’ included a collection of eyewitne