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BACKGROUND: A growing body of evidence links microRNAs (miRNAs) to major depressive disorder (MDD). However, the causal nature of these associations remains unclear.OBJECTIVES: This study aimed to investigate the potential causal association between miRNAs and MDD by combining Mendelian Randomization (MR) analyses and experimental validation.METHODS: Single-nucleotide polymorphisms (SNPs) signific

Introduction: Implementing new treatment regimens entails a learning phase with a concomitant risk of suboptimal results. High caseload has generally been shown to improve results in complex surgical procedures. This study aimed to evaluate results of Cytoreductive Surgery (CRS) and Intraperitoneal Chemotherapy (IP), given as Early Postoperative Intraperitoneal Chemotherapy (EPIC) or Hyperthermic

Objectives: To evaluate the test–retest reliability of a novel laboratory-based protocol for inducing and measuring head acceleration in multiple directions under anticipated and unanticipated conditions. Design: Laboratory-based test–retest reliability study. Methods: Thirty physically active adults (50% female) completed standardized head perturbations using a custom-built apparatus. Perturbatio

IntroductionSport-related concussion (SRC) is one of the most common and concerning injuries in team sports, with potential long-term effects on athlete health and performance. Linear head acceleration (LHA) and rotational head acceleration (RHA) are central biomechanical markers of brain loading during impact. Yet, the magnitude of these accelerations during SRC events remains poorly synthesized

Genetics as a science has roots in studying phenotypes of relatives, but molecular approaches facilitate direct measurements of genomic variation between individuals. Agricultural and human biomedical research are both emphasizing genotype-based instruments, such as polygenic scores, but unlike in agriculture, there is an emerging consensus that family variables act nearly independently of genotyp

Objective: Psychosocial stress increases the risk for subsequent episodes of alcohol use disorder (AUD) and drug use disorder (DUD), with most studies assessing stress exposure by questionnaire or interview methods. We developed an environmental risk score (ERS) using multiple classes of stressful life events (SLEs) obtained from national Swedish registries. Method: We assessed, in the entire adul

Background and purpose — Ankle arthrodesis (AA) and total ankle replacement are the 2 main surgical treatment options for advanced ankle arthritis but information is scarce on satisfaction and patient-reported outcome measures (PROMs) after surgery. We aimed to evaluate postoperative satisfaction, changes in PROMs from before to 2 years after AA, and factors associated with the outcome.Methods — T

Background: Ambulatory oxygen therapy can be used to treat exertional hypoxaemia during daily life activities in people with fibrotic interstitial lung disease (ILD). However, evidence for its efficacy is scarce. This trial aimed to compare the effects of ambulatory oxygen with ambulatory air on physical activity in daily life over 6 months in people with fibrotic ILD and isolated exertional hypox

Background: Evidence on the association between systemic glucocorticoid use and colorectal cancer (CRC) risk is limited. This study aimed to determine whether systemic glucocorticoid use is associated with an increased risk of overall CRC (diagnosed at any age) and early-onset CRC (EOCRC; diagnosed before 50 years of age). Methods: A nationwide cohort study (follow-up: 2005–2018) was conducted usi

Background: Swedish nationwide family and cancer data offer the largest global resource for study of familial cancer. We focus here on familial risks in prostate cancer (PC) with questions on risk in individuals from families of multiple affected members and association of familial risk with metastatic disease and survival. Methods: Familial relative risk of PC was estimated using standardized inc

INTRODUCTION: People with longstanding hip and groin pain (LHGP) are often referred to orthopaedic care. Physical therapist-led interventions are recommended in consensus statements as the first line of treatment, but it is unknown if structured interventions are more effective than usual care. The aim of this trial is to evaluate the effectiveness of a structured physical therapist-led treatment

BACKGROUND AND OBJECTIVE: Although the effects of 5-α-reductase inhibitors (5-ARIs) on prostate-specific antigen (PSA) have been well-studied, the effects on other kallikrein markers have not been firmly established. Accordingly, a statistical model based on blood measurements of four kallikreins-known commercially as the "4Kscore"-cannot be used for men taking 5-ARIs. We investigated how finaster

The growing passion for indoor optical wireless networks reflects their immense capability to deliver consistent high-quality data connectivity across diverse indoor environments. This study examines how polarization can be engineered to enhance near-field beam focusing in optical wireless indoor networks using a modular clustered optical phased array aperture. The aperture follows a ceiling-mount

This review aims to appraise and summarize the best available evidence from economic evaluations (EEs) of strategies targeting populations prior to a diagnosis of dementia. A comprehensive search was conducted in EMBASE, PubMed, EconLit, Web of Science, Cumulative Index to Nursing and Allied Health (CINAHL), and The NHS Economic Evaluation Database (NHS EED). Publications were dually screened and

Deciphering the genetic basis of prostate-specific antigen (PSA) levels may improve their utility for prostate cancer (PCa) screening. Using genome-wide summary statistics from 95,768 PCa-free men, we conducted a transcriptome-wide association study (TWAS) to examine impacts of genetically predicted gene expression on PSA. Analyses identified 41 statistically significant (p < 0.05/12,192 = 4.10×10

In this chapter, we argue that policy-making aiming to achieve environmentally sustainable transitions of the economy is in need of a solid empirical evidence base. Conventional measurement concepts used for example by the EU based on sector-classifications deliver highly biased pictures. We propose measurement concepts based on the use of green skills and human capital, validate key assumptions o